gene

NBEA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NBEA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

45Outgoing

36Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	NBEA
Full Name	Neurobeachin
Aliases	BCL8B
Chromosome	13q13.3
Protein Family	BEACH (Beige and Chediak-Higashi) family
Function	Scaffolding protein for protein kinase A, synaptic receptor trafficking
Primary Expression	Brain (high), heart, lung, testis
Molecular Weight	327.4 kDa
Amino Acids	2946
Exons	58 exons
Pathways	Synaptic plasticity, PKA signaling
UniProt ID	Q8NFP9
NCBI Gene ID	26045
Ensembl ID	ENSG00000172915
GeneCards	NBEA
Human Protein Atlas	NBEA
Associated Diseases	Alzheimer, Alzheimer'S Disease, Anxiety, Dementia, Depression
Interactions	GENES, PER
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NBEA — AlphaFold Q8NFP9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NBEA["NBEA"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"therapeutic target"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"associated"| Depression["Depression"]
    style Depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"associated"| Anxiety["Anxiety"]
    style Anxiety fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"associated"| HTR2C["HTR2C"]
    style HTR2C fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"associated"| ADRA2A["ADRA2A"]
    style ADRA2A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NBEA["NBEA"] -->|"associated"| BCHE["BCHE"]
    style BCHE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MAOB["MAOB"] -->|"associated"| NBEA["NBEA"]
    style MAOB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GABRA1["GABRA1"] -->|"associated"| NBEA["NBEA"]
    style GABRA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CHAT["CHAT"] -->|"associated"| NBEA["NBEA"]
    style CHAT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CYP2D6["CYP2D6"] -->|"associated"| NBEA["NBEA"]
    style CYP2D6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"associated"| NBEA["NBEA"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style NBEA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (45)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
PDK3	associated_with	gene	0.60
SLC30A8	associated_with	entity	0.60
APOE	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Epigenetic	therapeutic_target	pathway	0.60
Epigenetic	associated_with	pathway	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
Epigenetic	interacts_with	pathway	0.60
PER	interacts_with	gene	0.60
CYP3A5	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50

Incoming (36)

Source	Relation	Type	Str
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
RB1	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
MTHFR	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
ANXIETY	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NBEA

Understanding Entity Pages

Wiki Pages (4)

NBEA — Neurobeachin

OPRM1 — Mu-Opioid Receptor