PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3

PDK3 Gene — 3-Phosphoinositide-Dependent Protein Kinase 3

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>PDK3</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>3-Phosphoinositide-Dependent Protein Kinase 3</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>Xp22.11</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>5165</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>300341</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000168268</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O95819</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>350 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~39 kDa</td>
</tr>
<tr>
<td class="label">Compound</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">BX-517</td>
<td>PDK1/3 selective inhibitor</td>
</tr>
<tr>
<td class="label">OSU-03012</td>
<td>Multi-PDK inhibitor</td>
</tr>
<tr>
<td class="label">Compound 20</td>
<td>PDK3 selective</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/colorectal-cancer" style="color:#ef9a9a">Colorectal Cancer</a>, <a href="/wiki/tumor" style="color:#

PDK3 Gene — 3-Phosphoinositide-Dependent Protein Kinase 3

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>PDK3</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>3-Phosphoinositide-Dependent Protein Kinase 3</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>Xp22.11</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>5165</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>300341</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000168268</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O95819</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>350 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~39 kDa</td>
</tr>
<tr>
<td class="label">Compound</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">BX-517</td>
<td>PDK1/3 selective inhibitor</td>
</tr>
<tr>
<td class="label">OSU-03012</td>
<td>Multi-PDK inhibitor</td>
</tr>
<tr>
<td class="label">Compound 20</td>
<td>PDK3 selective</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/colorectal-cancer" style="color:#ef9a9a">Colorectal Cancer</a>, <a href="/wiki/tumor" style="color:#ef9a9a">Tumor</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">25 edges</a></td>
</tr>
</table>

Introduction

The PDK3 gene (3-Phosphoinositide-Dependent Protein Kinase 3) encodes a member of the phosphoinositide-dependent protein kinase (PDK) family. PDK3 is a serine/threonine kinase that plays important roles in cell survival, metabolism, and stress responses["@liu2008"]. It is expressed in various tissues, with high expression in brain, and is implicated in neurodegenerative diseases and cancer.

Gene Information

Protein Structure

PDK3 contains characteristic features:

• Kinase Domain: Serine/threonine kinase activity
• PH Domain: Phosphoinositide binding (present in some isoforms)
• Regulatory Regions: Autoinhibitory and activation segments

Normal Cellular Function

Cell Survival Signaling

• Akt Activation: PDK3 phosphorylates and activates Akt/PKB
• PKC Activation: Regulates protein kinase C isoforms
• Cell Survival: Promotes cell survival under stress conditions

Metabolic Regulation

• Glucose Metabolism: Insulin signaling pathway component
• Lipid Metabolism: Affects lipid synthesis and storage
• Mitochondrial Function: Regulates mitochondrial activity

Stress Responses

• Oxidative Stress: Activated in response to ROS
• DNA Damage: Involved in DNA damage responses
• Hypoxia: Regulates hypoxic responses

Expression Pattern

PDK3 is widely expressed:

• Brain: Neurons in cortex, hippocampus, cerebellum
• Heart, skeletal muscle
• Liver, kidney
• Pancreas

Disease Associations

Alzheimer's Disease

• Tau Phosphorylation: May contribute to tau pathology
• Cell Survival: Dysregulation affects neuronal viability
• Metabolic Dysfunction: Links to brain metabolic deficits

Parkinson's Disease

• Dopaminergic Neurons: Altered expression in substantia nigra
• Mitochondrial Function: Regulates mitochondrial health

Cancer

• Oncogenic Role: Overexpressed in various cancers
• Cell Proliferation: Promotes cancer cell growth
• Therapeutic Target: PDK3 inhibitors in development

Metabolic Disorders

• Diabetes: Altered insulin signaling
• Obesity: Metabolic dysfunction

Signaling Pathways

PDK3 participates in multiple pathways:

• PI3K/Akt Pathway: Central cell survival pathway
• mTOR Pathway: Growth and metabolism regulation
• AMPK Pathway: Energy sensing
• MAPK Pathway: Stress responses

Therapeutic Targeting

Research Highlights

• PDK3 knockout mice show developmental abnormalities
• PDK3 promotes neuronal survival under stress conditions
• Targeting PDK3 shows therapeutic potential in models

See Also

• [PDK1 Gene](/genes/pdk1)
• [AKT Signaling Pathway](/mechanisms/akt-signaling-pathway)
• [PI3K/Akt Pathway](/mechanisms/pi3k-akt-pathway)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Cell Survival Pathways](/mechanisms/cell-survival-pathways)

External Links

• [NCBI Gene: PDK3](https://www.ncbi.nlm.nih.gov/gene/5165)
• [UniProt: O95819](https://www.uniprot.org/uniprot/O95819)
• [GeneCards: PDK3](https://www.genecards.org/cgi-bin/carddisp.pl?gene=PDK3)

References

Pathway Diagram

The following diagram shows the key molecular relationships involving PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3 discovered through SciDEX knowledge graph analysis: