Gene Rankings
Overview
flowchart TD
RANKINGS["RANKINGS"] -->|"interacts with"| Aging["Aging"]
RANKINGS["RANKINGS"] -->|"interacts with"| Als["Als"]
RANKINGS["RANKINGS"] -->|"interacts with"| Cancer["Cancer"]
RANKINGS["RANKINGS"] -->|"associated with"| Lymphoma["Lymphoma"]
RANKINGS["RANKINGS"] -->|"interacts with"| Tumor["Tumor"]
RANKINGS["RANKINGS"] -->|"interacts with"| RAC1["RAC1"]
RANKINGS["RANKINGS"] -->|"associated with"| MAPK1["MAPK1"]
RANKINGS["RANKINGS"] -->|"interacts with"| PI3K["PI3K"]
RANKINGS["RANKINGS"] -->|"associated with"| CBL["CBL"]
RANKINGS["RANKINGS"] -->|"interacts with"| AKT["AKT"]
RANKINGS["RANKINGS"] -->|"interacts with"| RHOA["RHOA"]
RANKINGS["RANKINGS"] -->|"interacts with"| TRAF2["TRAF2"]
RANKINGS["RANKINGS"] -->|"interacts with"| TRAF6["TRAF6"]
RANKINGS["RANKINGS"] -->|"interacts with"| TGFBR1["TGFBR1"]
style RANKINGS fill:#4fc3f7,stroke:#333,color:#000
...
Gene Rankings
Overview
Mermaid diagram (expand to render)
<table class="infobox infobox-gene">
This page ranks genes associated with neurodegenerative diseases by various criteria including disease relevance, research activity, therapeutic target validation, and knowledge base coverage in NeuroWiki. [@app2013]
Rankings by Alzheimer's Disease Relevance
Rankings by Parkinson's Disease Relevance
Rankings by ALS/FTD Relevance
Rankings by Therapeutic Target Validation Genes with strong evidence for therapeutic targeting:
Gene Categories
Alzheimer's Disease Genes
Amyloid pathway : [APP](/genes/app), [APOE](/genes/apoe), [PSEN1](/genes/psen1), [PSEN2](/genes/psen2), [BACE1](/genes/bace1)Tau pathway : [MAPT](/genes/mapt), [GSK3B](/genes/gsk3b), [CDK5](/genes/cdk5)Neuroinflammation : [TREM2](/genes/trem2), [CLU](/genes/clu), [ABCA7](/genes/abca7)Parkinson's Disease Genes
Synucleinopathy : [SNCA](/genes/snca), [GBA](/genes/gba), [LRRK2](/genes/lrrk2)Mitochondrial quality control : [PARK2](/genes/park2), [PINK1](/genes/pink1), [DJ-1](/genes/dj-1)Protein clearance : [ATP13A2](/genes/atp13a2), [DNAJC13](/genes/dnajc13)ALS/FTD Genes
RNA metabolism : [C9orf72](/genes/c9orf72), [TARDBP](/genes/tardbp), [FUS](/genes/fus)Protein homeostasis : [SOD1](/genes/sod1), [UBQLN2](/genes/ubqln2), [VCP](/genes/vcp)Autophagy : [OPTN](/genes/optn), [TBK1](/genes/tbk1), [SQSTM1](/genes/sqstm1)See Also
[Alzheimer's Disease](/diseases/alzheimers-disease)
[Parkinson's Disease](/diseases/parkinsons-disease)
External Links
[NCBI Gene: APP](https://www.ncbi.nlm.nih.gov/gene/?term=APP)
[GeneCards: APP](https://www.genecards.org/cgi-bin/carddisp.pl?gene=APP)
[OMIM: APP](https://omim.org/search?search=APP)
[Ensembl: APP](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=APP)
[Allen Brain Atlas: APP](https://human.brain-map.org/microarray/search/show?search_term=APP)
Coverage Gaps
Top Entries with Thin Coverage These ranked items have limited content and would benefit from expansion:
[DNAJC13 — 2,858 characters](/genes/ar)
[CLU — 5,963 characters](/genes/ar)
[CDK5 — 6,542 characters](/genes/ar)
[GSK3B — 6,553 characters](/companies/gsk)
[DJ-1 — 6,659 characters](/genes/ar)
[ABCA7 — 7,173 characters](/genes/ar)
[BACE1 — 8,112 characters](/genes/ar)
[PARK2 — 9,135 characters](/genes/ar)
[PSEN1 — 9,211 characters](/genes/ar)
[UBQLN2 — 9,451 characters](/genes/ar)
References
[Unknown, APP and Alzheimer's disease (2013)](https://pubmed.ncbi.nlm.nih.gov/23550210/)
[Unknown, SNCA and Parkinson's disease (2019)](https://pubmed.ncbi.nlm.nih.gov/31479456/)
[Unknown, C9orf72 ALS/FTD genetics (2011)](https://pubmed.ncbi.nlm.nih.gov/22003155/) Show full description