Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about rankings: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Zha et al. (2025) | Cell Metabolism: B. ovatus-derived lysophosphatidylcholine suppresses ferroptosis in AD |
| Wang et al. (2025) | Microbiome: A. muciniphila and propionic acid maintain mitochondrial homeostasis via GPR41/43 |
| Li et al. (2025) | Science Advances: Gut microbial-derived indole-3-propionate improves cognition in AD |
| Kang et al. (2025) | Alzheimer's & Dementia: Gut microbiome composition associates with AD pathology |
| PMID: 39905278 | P. gingivalis induces kynurenine metabolism disturbance via gut-brain axis |
| PMID: 39953680 | P. gingivalis impairs microglial Aβ clearance in mouse model |
| PMID: 40028317 | P. gingivalis as potential trigger of neurodegenerative disease |
| PMID: 40684176 | Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis |
| PMID: 40060035 | Association between periodontitis and AD: narrative review |
| PMID: 40406128 | AI and omics-based autoantibody profiling in dementia |
| PMID: 40281535 | CAA-related inflammation as subacute autoimmune encephalopathy |
| PMID: 40842786 | Chronic inflammatory conditions as risk factors for neurodegeneration |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
RANKINGS["RANKINGS"]
RANKINGS -->|"interacts"| Aging["Aging"]
RANKINGS -->|"interacts"| Als["Als"]
RANKINGS -->|"interacts"| Cancer["Cancer"]
RANKINGS -->|"interacts"| Tumor["Tumor"]
RANKINGS -->|"interacts"| RAC1["RAC1"]
RANKINGS -->|"interacts"| PI3K["PI3K"]
RANKINGS -->|"interacts"| AKT["AKT"]
RANKINGS -->|"interacts"| RHOA["RHOA"]| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| RAC1 | interacts_with | gene | 0.60 |
| MAPK1 | associated_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| CBL | associated_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| RHOA | interacts_with | gene | 0.60 |
| TRAF2 | interacts_with | gene | 0.60 |
| TRAF6 | interacts_with | gene | 0.60 |
| TGFBR1 | interacts_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| RAF1 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ACVR1 | interacts_with | gene | 0.60 |
| Insulin Signaling | interacts_with | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
| Pi3K | interacts_with | pathway | 0.60 |
| benchmark_ot_ad_answer_key:RANKINGS | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIK3CA | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:RANKINGS | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||