Protein Rankings

Migration, Crosslink

📗 Cite This Artifact

←

Home / Artifacts / Protein Rankings

📖

Protein Rankings

active

wiki page Created: 2026-04-02T07:19:15 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-proteins-rankings

📖 Wiki Page

protein732 wordssynced 2026-04-02

Protein Rankings

Overview

...

Protein Rankings

Overview

Mermaid diagram (expand to render)

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">Protein Rankings</th>
</tr>
<tr>
<td class="label">Rank</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">1</td>
<td>Amyloid-beta (Abeta)</td>
</tr>
<tr>
<td class="label">2</td>
<td>[Tau](/proteins/tau) (MAPT)</td>
</tr>
<tr>
<td class="label">3</td>
<td>APP</td>
</tr>
<tr>
<td class="label">4</td>
<td>[TREM2](/proteins/trem2)</td>
</tr>
<tr>
<td class="label">5</td>
<td>[APOE](/proteins/apoe)</td>
</tr>
<tr>
<td class="label">6</td>
<td>BACE1</td>
</tr>
<tr>
<td class="label">7</td>
<td>Clusterin</td>
</tr>
<tr>
<td class="label">8</td>
<td>[GFAP](/entities/gfap)</td>
</tr>
<tr>
<td class="label">9</td>
<td>[Neurofilament light](/biomarkers/neurofilament-light-chain-nfl) chain (NfL)</td>
</tr>
<tr>
<td class="label">10</td>
<td>Synaptic proteins</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">1</td>
<td>Alpha-synuclein</td>
</tr>
<tr>
<td class="label">2</td>
<td>LRRK2</td>
</tr>
<tr>
<td class="label">3</td>
<td>GCase (GBA)</td>
</tr>
<tr>
<td class="label">4</td>
<td>Parkin</td>
</tr>
<tr>
<td class="label">5</td>
<td>PINK1</td>
</tr>
<tr>
<td class="label">6</td>
<td>DJ-1</td>
</tr>
<tr>
<td class="label">7</td>
<td>VPS35</td>
</tr>
<tr>
<td class="label">8</td>
<td>Synphilin-1</td>
</tr>
<tr>
<td class="label">9</td>
<td>GSN (Gelsolin)</td>
</tr>
<tr>
<td class="label">10</td>
<td>ATP13A2 (PARK9)</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">1</td>
<td>[TDP-43](/mechanisms/tdp-43-proteinopathy)</td>
</tr>
<tr>
<td class="label">2</td>
<td>FUS</td>
</tr>
<tr>
<td class="label">3</td>
<td>SOD1</td>
</tr>
<tr>
<td class="label">4</td>
<td>[C9orf72](/entities/c9orf72) protein</td>
</tr>
<tr>
<td class="label">5</td>
<td>OPTN</td>
</tr>
<tr>
<td class="label">6</td>
<td>TBK1</td>
</tr>
<tr>
<td class="label">7</td>
<td>VCP/ALS4</td>
</tr>
<tr>
<td class="label">8</td>
<td>Ubiquilin-2</td>
</tr>
<tr>
<td class="label">9</td>
<td>Peripherin</td>
</tr>
<tr>
<td class="label">10</td>
<td>Astrocytic proteins</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">1</td>
<td>Amyloid-beta</td>
</tr>
<tr>
<td class="label">2</td>
<td>Tau</td>
</tr>
<tr>
<td class="label">3</td>
<td>Alpha-synuclein</td>
</tr>
<tr>
<td class="label">4</td>
<td>TREM2</td>
</tr>
<tr>
<td class="label">5</td>
<td>LRRK2</td>
</tr>
<tr>
<td class="label">6</td>
<td>SOD1</td>
</tr>
<tr>
<td class="label">7</td>
<td>GCase</td>
</tr>
<tr>
<td class="label">8</td>
<td>BACE1</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/aging" style="color:#ef9a9a">Aging</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/lymphoma" style="color:#ef9a9a">Lymphoma</a>, <a href="/wiki/tumor" style="color:#ef9a9a">Tumor</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">24 edges</a></td>
</tr>
</table>

This page ranks proteins associated with neurodegenerative diseases by various criteria including disease relevance, research activity, therapeutic target validation, and knowledge base coverage in NeuroWiki. [@amyloidbeta2023]

Rankings by Alzheimer's Disease Relevance

Rankings by Parkinson's Disease Relevance

Rankings by ALS/FTD Relevance

Rankings by Therapeutic Target Validation

Proteins with strong evidence for therapeutic targeting:

Protein Categories

Amyloid and APP Family

[Amyloid Precursor Protein (APP)](/amyloid-precursor-protein-))))))))) — transmembrane protein cleaved to produce Aβ
[Amyloid-beta (Aβ40, Aβ42)](/proteins/amyloid-beta) — aggregation-prone peptide forming plaques
[APOE](/genes/apoe) — lipid carrier affecting Aβ clearance

Tau and Microtubule Proteins

[Tau (MAPT)](/proteins/tau) — microtubule stabilizer forming neurofibrillary tangles
[Phosphorylated tau (p-tau181, p-tau217, p-tau231)](/proteins/phosphorylated-tau) — disease-specific tau forms

Synuclein Family

[Alpha-synuclein](/proteins/alpha-synuclein) — Lewy body component, presynaptic protein
[Beta-synuclein](/proteins/beta-synuclein) — synuclein family member
[Gamma-synuclein](/proteins/gamma-synuclein) — synuclein family member

Neurodegeneration Markers

[Neurofilament Light Chain (NfL)](/proteins/neurofilament-light-chain) — generic neurodegeneration marker
[Neurofilament Heavy Chain (NfH)](/proteins/neurofilament-heavy-chain) — axonal injury marker
[GFAP](/proteins/gfap) — astrocyte activation marker
[Tau](/proteins/tau) — neuronal injury marker

External Links

[GeneCards: APOE](https://www.genecards.org/cgi-bin/carddisp.pl?gene=APOE)

Coverage Gaps

Top Entries with Thin Coverage

These ranked items have limited content and would benefit from expansion:

[Neurofilament Light Chain (NfL) — 7,085 characters](/genes/ar)
[Beta-synuclein — 7,297 characters](/institutions/ucl)
[Neurofilament Heavy Chain (NfH) — 7,917 characters](/genes/ar)
[Gamma-synuclein — 8,120 characters](/institutions/ucl)
[Alpha-synuclein — 13,834 characters](/institutions/ucl)

Missing Pages

These items are listed in rankings but have no corresponding wiki page:

[Phosphorylated tau (p-tau181, p-tau217, p-tau231) — *MISSING](/proteins/tau)

References

[Unknown, Amyloid-beta immunotherapy (2023)](https://pubmed.ncbi.nlm.nih.gov/36653581/)

[Unknown, Alpha-synuclein and Parkinson's disease (2019)](https://pubmed.ncbi.nlm.nih.gov/31479456/)

[Unknown, TDP-43 proteinopathies (2010)](https://pubmed.ncbi.nlm.nih.gov/20690138/)

📖 View canonical wiki page →

Related Entities

RANKINGS

▸Metadataorigin_type: v1_polymorphic_backfill

slug	proteins-rankings
kg_node_id	RANKINGS
entity_type	protein
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-77f97c03d129
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'proteins-rankings'}
_schema_version	1

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

50%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

View full evidence profile →

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

This artifact has no version history yet.

Linked Artifacts (50)

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

see_also📖CBL Gene60%

see_also📖PIK3CA Gene60%

see_also📖ACVR1 Gene60%

see_also📖TGFBR1 — TGF-beta Receptor 160%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)60%

see_also📖MAPK1 Gene60%

see_also📖RHOA Gene — Ras Homolog Family Member A60%

see_also📖PTEN Gene60%

see_also📖PI3K — Phosphoinositide 3-Kinase60%

see_also📖MAPK Signaling Pathways in Neurodegeneration60%

see_also📖RAC1 Gene60%

see_also📖CDC42 Gene60%

see_also📖Packard Center for ALS Research60%

mentions🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪APOE Isoform Conversion Therapy50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE-TREM2 Interaction Modulation50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

Reference URLs

Canonical (singular)/artifact/wiki-proteins-rankingscanonical

Canonical (plural, REST)/artifacts/wiki-proteins-rankingsalias

API (JSON)/api/artifacts/wiki-proteins-rankingsapi

Citation — BibTeX/artifacts/wiki-proteins-rankings/cite?fmt=bibtexexport

Citation — RIS/artifacts/wiki-proteins-rankings/cite?fmt=risexport

Citation — CSL-JSON/artifacts/wiki-proteins-rankings/cite?fmt=cslexport

Embed this artifact

Use ?embed=1 to load the artifact without SciDEX chrome — suitable for iframing into wiki pages or external sites.

HTML iframe

<iframe src="http://scidex.ai/artifact/wiki-proteins-rankings?embed=1" width="100%" height="600" style="border:0;border-radius:8px"></iframe>

Markdown link

[Protein Rankings](http://scidex.ai/artifact/wiki-proteins-rankings)

Direct URL

http://scidex.ai/artifact/wiki-proteins-rankings

Preview

🔄 Adjacent Artifacts Recommended based on your interests

💬 Discussion

Loading comments...

Public annotations (0)Annotate on Hypothes.is →

No public annotations yet.

📗 Cite This Artifact

Protein Rankings

Protein Rankings

Overview

Protein Rankings

Overview

Rankings by Alzheimer's Disease Relevance

Rankings by Parkinson's Disease Relevance

Rankings by ALS/FTD Relevance

Rankings by Therapeutic Target Validation

Protein Categories

Amyloid and APP Family

Tau and Microtubule Proteins

Synuclein Family

Neurodegeneration Markers

See Also

External Links

Coverage Gaps

Top Entries with Thin Coverage

Missing Pages

References

💬 Discussion