concept

MEK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

300Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MEK
Key Genes/Proteins	ERK, RAF, LRRK2, β-catenin, RAS
Related Diseases	Tumor
Related Pathways	MAPK signaling, oxidative stress response, PI3K-AKT-mTOR signaling

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MEK["MEK"]
    style MEK fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MEK -->|"phosphorylates"| ERK([ERK])
    MEK -.->|"inhibits"| Tumor["Tumor"]
    MEK -.->|"inhibits"| Cancer["Cancer"]
    MEK -.->|"inhibits"| ALS["ALS"]
    MEK -.->|"inhibits"| Senescence["Senescence"]
    MEK -->|"activates"| Aging["Aging"]
    MEK -.->|"inhibits"| Glioblastoma["Glioblastoma"]
    RAF([RAF]) -->|"activates"| MEK
    NST_628{"NST-628"} -.->|"inhibits"| MEK
    Trametinib{"Trametinib"} -.->|"inhibits"| MEK
    __catenin([beta-catenin]) -->|"upstream_of"| MEK
    RAS([RAS]) -->|"activates"| MEK
    TRAMETINIB{"TRAMETINIB"} -.->|"inhibits"| MEK
    KRAS_G12C_inhibitors{"KRAS G12C inhibitors"} -->|"interacts"| MEK
    BRAF([BRAF]) -.->|"inhibits"| MEK
    TARDBP([TARDBP]) -->|"interacts"| MEK

Outgoing (176)

Target	Relation	Type	Str
ERK	phosphorylates	protein	0.95
ERK	activates	protein	0.95
MAPK signaling	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
Senescence	activates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Lymphoma	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
TARDBP	phosphorylates	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
JNK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Cell Cycle	inhibits	pathway	0.60
BRAF	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
RAS	activates	gene	0.60
CANCER	activates	gene	0.60
KRAS	activates	gene	0.60
Mapk	activates	pathway	0.60
GLIOBLASTOMA	inhibits	gene	0.60
Complement	activates	pathway	0.60
EZH2	activates	gene	0.60
Immune Response	activates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60

Incoming (124)

Source	Relation	Type	Str
RAF	activates	gene	0.95
NST-628	inhibits	drug	0.95
Trametinib	inhibits	drug	0.90
RAF	phosphorylates	protein	0.90
Binimetinib	inhibits	drug	0.90
LRRK2	activates	gene	0.90
β-catenin	upstream_of	protein	0.85
RAS	activates	protein	0.80
TRAMETINIB	inhibits	drug	0.72
KRAS G12C inhibitors	interacts_with	drug	0.72
BRAF	inhibits	gene	0.65
TARDBP	interacts_with	gene	0.60
BAD	inhibits	gene	0.60
AKT	inhibits	gene	0.60
HER2	inhibits	gene	0.60
DR5	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
JUN	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
AND	inhibits	gene	0.60
KIAA1549::BRAF	inhibits	gene	0.60
CDK1	inhibits	gene	0.60
KIAA1549	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
RNA	inhibits	gene	0.60
IRS1	inhibits	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
GBM	inhibits	gene	0.60
DNA	inhibits	gene	0.60
AGING	activates	gene	0.60
BMP2	inhibits	gene	0.60
AXL	activates	gene	0.60
ROS	activates	gene	0.60
IRS1	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
ERK	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
MTOR	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
PTEN	contributes_to	gene	0.60
PIK3CA	contributes_to	gene	0.60
RAS	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
MAPK	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
TDP-43	activates	gene	0.60
SIRT1	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
ROS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MEK

Understanding Entity Pages

Wiki Pages (20)

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nf1-protein

IGF-1 Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CNTFR Gene

EPHA7 Gene

EPHA6 — Ephrin Type-A Receptor 6

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

BDNF/Neurotrophin Signaling in Neurodegeneration

FGF Signaling Pathway in Neurodegeneration

MAPK/ERK Signaling Pathway in Neurodegeneration

EPHA8 Gene