Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aβ Production: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Hypoxia | associated_with | process | 0.95 |
| Cytotrophoblasts | involved_in | cell_type | 0.90 |
| NAAA | inhibits | enzyme | 0.90 |
| 19775776 | increase | paper | 0.90 |
| BACE1 | enhances | gene | 0.90 |
| sphingomyelin accumulation | causes | phenotype | 0.90 |
| altered APP/processing enzyme trafficking | regulates | phenotype | 0.90 |
| Bace1 | causes | protein | 0.90 |
| SORL1 | modulates | protein | 0.90 |
| LRP1 | inhibits | gene | 0.80 |
| APOE | regulates | gene | 0.80 |
| IL1B | causes | gene | 0.70 |
| TNF | causes | gene | 0.70 |
| raft-specific ceramide metabolism | inhibits | pathway | 0.70 |
| APP mislocalization | increases | mechanism | 0.70 |
| salsalate | inhibits | drug | 0.70 |
| Retromer dysfunction | causes | phenotype | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CYP46A1 Activation as a Therapeutic Strategy to Restore Neur | 0.550 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.380
proteomics | 2026-04-16 | 19 hypotheses Top: 0.591
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.732
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.734
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
closed · Rounds: 4 · Score: 0.84 · 2026-04-16
closed · Rounds: 4 · Score: 0.71 · 2026-04-16
closed · Rounds: 4 · Score: 0.75 · 2026-04-16
Hypotheses and analyses mentioning Aβ Production in their description or question text
No additional research found