gene

adcy8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adcy8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
7Hypotheses
2Analyses
30Outgoing
3Incoming
3Experiments
2Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info
Gene SymbolADCY8
Full NameAdenylate Cyclase 8
Chromosome8q24.22
FunctionADCY8 plays essential roles in neuronal physiology:
Molecular Weight125 kDa
Exons28
GeneCardsADCY8
Human Protein AtlasADCY8
N-terminal extracellular domainContains glycosylation sites
Transmembrane region (M1-M6)Forms the membrane-spanning core
Calmodulin-binding domainLocated in the C-terminal cytoplasmic region
Cerebral cortexLayer-specific expression in pyramidal neurons
CerebellumEnriched in Purkinje cells
Associated Diseaseslong_term_spatial_memory_formation, migratory distance
InteractionsPKA
SciDEX HypothesesADCY8-Mediated Synaptic Tagging for Spatial Memori
Epigenetic ADCY8 Memory Programming
Circadian-Spatial Memory Coupling Therapy (+4 more)
KG Connections33 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADCY8 Gene

gene · 863 words

Pathway Diagram

flowchart TD
    N0["ADCY8"]
    N1["AND"]
    N0 -->|"regulates"| N1
    N2["Ras"]
    N0 -->|"expressed in"| N2
    N3["App"]
    N0 -->|"expressed in"| N3
    N4["neurodegeneration"]
    N0 -->|"implicated in"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 protein
    class N3 protein

Outgoing (30)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:ADCY8data_indataset_row0.00
spatial_navigationmodulatescognitive_function0.90
cAMPproducesmolecule0.90
PKA-CREB signaling cascadeactivatespathway0.90
long-term spatial memory formationregulatesmechanism0.90

Incoming (3)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:ADCY8data_indataset_row0.00
long-term memorydrivesprocess0.75
Falco peregrinusexpressed_incell_type0.70

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
ADCY8-PKA-CREB Spatial Memory Enhancement 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
ADCY8-cAMP Memory Consolidation Enhancer 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
Hippocampal ADCY8 Upregulation for Alzheimer's Navigation De 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
ADCY8-Mediated Synaptic Tagging for Spatial Memories 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
Circadian-Spatial Memory Coupling Therapy 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
Epigenetic ADCY8 Memory Programming 0.455 memory-and-navigation How does ADCY8 mechanistically regulate
Magnetic Field Sensing-Memory Interface Therapy 0.455 memory-and-navigation How does ADCY8 mechanistically regulate

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

How does ADCY8 mechanistically regulate long-term memory formation in migratory

memory and navigation | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (3)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Genome resequencing and GWAS for migratory distance in peregrine falco exploratory 0.850 0.00 wild peregrine falcons (Falco proposed N/A
Genome resequencing and association with migratory distance exploratory 0.850 0.00 wild peregrine falcon populati proposed N/A
ADCY8 regulatory mechanism investigation exploratory 0.750 0.00 peregrine falcon populations proposed N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The study identifies ADCY8 as associated with migratory distance differences and

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning adcy8 in their description or question text

Epigenetic ADCY8 Memory Programming

Score: 0.455 · memory-and-navigation · 2026-04-27

The memory-based navigation differences associated with ADCY8 may involve epigenetic programming during critical develop

Magnetic Field Sensing-Memory Interface Therapy

Score: 0.455 · memory-and-navigation · 2026-04-27

ADCY8 may integrate magnetic field sensing with memory formation for navigation. Therapeutic stimulation combining magne