Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about hippocampus: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
hippocampus["hippocampus"] -->|"involved in"| memory["memory"]
style memory fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
hippocampus["hippocampus"] -->|"involved in"| stress_response["stress response"]
style stress_response fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
hippocampus["hippocampus"] -->|"mediates"| cognitive_performance["cognitive performance"]
style cognitive_performance fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
hippocampus["hippocampus"] -->|"involved in"| cognitive_decline["cognitive decline"]
style cognitive_decline fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
hippocampus["hippocampus"] -->|"biomarker for"| Alzheimer_s_disease["Alzheimer's disease"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
epilepsy["epilepsy"] -->|"affects"| hippocampus["hippocampus"]
style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
RNA["RNA"] -->|"expressed in"| hippocampus["hippocampus"]
style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Alzheimer_s_disease_1["Alzheimer's disease"] -->|"affects"| hippocampus["hippocampus"]
style Alzheimer_s_disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
synaptic_plasticity["synaptic plasticity"] -->|"active in"| hippocampus["hippocampus"]
style synaptic_plasticity fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"affects"| hippocampus["hippocampus"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style hippocampus fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| memory | involved_in | phenotype | 0.95 |
| stress response | involved_in | process | 0.90 |
| cognitive performance | mediates | phenotype | 0.85 |
| cognitive decline | involved_in | phenotype | 0.80 |
| Alzheimer's disease | biomarker_for | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| epilepsy | affects | disease | 0.90 |
| RNA | expressed_in | gene | 0.90 |
| Alzheimer's disease | affects | disease | 0.90 |
| synaptic plasticity | active_in | pathway | 0.90 |
| neurodegeneration | affects | disease | 0.90 |
| neuroinflammation | affects | disease | 0.90 |
| BDNF | expressed_in | gene | 0.90 |
| depression | affects | disease | 0.90 |
| unfolded protein response | active_in | pathway | 0.90 |
| APP | expressed_in | gene | 0.90 |
| aging | affects | disease | 0.90 |
| glutamate signaling | active_in | pathway | 0.90 |
| TNF | expressed_in | gene | 0.90 |
| BDNF-TrkB signaling | active_in | pathway | 0.90 |
| NMDA receptor | expressed_in | receptor | 0.90 |
| microglia | expressed_in | cell_type | 0.90 |
| HCN2 | expressed_in | gene | 0.90 |
| 1-bromopropane | causes | compound | 0.90 |
| TREM2 | expressed_in | gene | 0.88 |
| BCL2 | expressed_in | protein | 0.88 |
| hypoxic-ischemic brain injury | associated_with | disease | 0.85 |
| indole-3-lactic acid | expressed_in | protein | 0.80 |
| anxiety | affects | disease | 0.80 |
| CREB | expressed_in | gene | 0.80 |
| PSEN1 | expressed_in | gene | 0.80 |
| PI3K-AKT-mTOR signaling | active_in | pathway | 0.80 |
| AKT | expressed_in | gene | 0.80 |
| PI3K | expressed_in | gene | 0.80 |
| ferroptosis | active_in | pathway | 0.80 |
| GABA | expressed_in | gene | 0.80 |
| NLRP3 | expressed_in | gene | 0.80 |
| pyroptosis | active_in | pathway | 0.80 |
| diabetes | affects | disease | 0.80 |
| NGF | expressed_in | gene | 0.80 |
| serotonin | active_in | neurotransmitter | 0.80 |
| PTSD | affects | disease | 0.80 |
| spinal muscular atrophy | affects | disease | 0.80 |
| AMPA receptor | expressed_in | receptor | 0.80 |
| axon | enriched_in | organelle | 0.80 |
| BACE1 | expressed_in | gene | 0.80 |
| complement cascade | modulates | pathway | 0.80 |
| LRP-1 | expressed_in | gene | 0.80 |
| LC3 | expressed_in | protein | 0.75 |
| aerobic exercise | modulates | process | 0.75 |
| BMSC-exos | expressed_in | cell_type | 0.70 |
| SNCA | expressed_in | protein | 0.70 |
| mitophagy | expressed_in | process | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| blood-brain barrier | regulates | process | 0.70 |
| autophagic cell death | associated_with | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||