Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ROS | associated_with | gene | 0.70 |
| ROS | biomarker_for | gene | 0.70 |
| ROS | inhibits | gene | 0.70 |
| TNF | expressed_in | gene | 0.60 |
| S100B | activates | gene | 0.60 |
| TGM2 | activates | gene | 0.60 |
| PGC1A | activates | gene | 0.60 |
| PLIN2 | activates | gene | 0.60 |
| PPARA | activates | gene | 0.60 |
| SGLT2 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| NTS | associated_with | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| VIM | biomarker_for | gene | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| TOMM20 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TH | activates | gene | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| neuroinflammation | associated_with | disease | 0.60 |
| RB1 | biomarker_for | gene | 0.60 |
| Notch signaling | participates_in | pathway | 0.60 |
| TCF4 | activates | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| RIPK1 | activates | gene | 0.60 |
| RIPK3 | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| PTX3 | activates | gene | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| PKM2 | inhibits | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| traumatic brain injury | activates | disease | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| NLR | associated_with | gene | 0.60 |
| NLR | biomarker_for | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Glucose | upregulates | compound | 0.90 |
| high glucose | upregulates | compound | 0.85 |
| AE | downregulates | compound | 0.80 |
| GPX1 | biomarker_for | gene | 0.60 |
| ADIPOQ | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| C3 | activates | gene | 0.60 |
| HMGB1 | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| CASP1 | activates | gene | 0.60 |
| GSDMD | activates | gene | 0.60 |
| IL1B | activates | gene | 0.60 |
| DGAT1 | activates | gene | 0.60 |
| LC3 | inhibits | gene | 0.60 |
| CHMP4B | associated_with | gene | 0.60 |
| quercetin | targets | drug | 0.60 |
| GR | biomarker_for | gene | 0.60 |
| GSDME | activates | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CD31 | regulates | gene | 0.60 |
| CKB | regulates | gene | 0.60 |
| CTS | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| GHRL | activates | gene | 0.60 |
| CX43 | biomarker_for | gene | 0.60 |
| GSH | biomarker_for | gene | 0.60 |
| HIF | activates | gene | 0.60 |
| ATP | associated_with | gene | 0.60 |
| ATP | inhibits | gene | 0.60 |
| HIF | interacts_with | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| ANXA5 | regulates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| AGER | associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||