entity

mTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about mTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9715Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    mTOR["mTOR"]
    PI3K["PI3K"]
    AKT["AKT"]
    AMPK["AMPK"]
    TSC_complex["TSC1-TSC2 Complex"]
    PTEN["PTEN"]
    autophagy["Autophagy"]
    ULK1["ULK1"]
    TFEB["TFEB"]
    cell_growth["Cell Growth"]
    metabolism["Metabolism"]
    aging["Aging"]
    neurodegeneration["Neurodegeneration"]
    rapamycin["Rapamycin"]
    lysosomal_biogenesis["Lysosomal Biogenesis"]

    PI3K -->|"activates"| AKT
    AKT -->|"activates"| mTOR
    PTEN -->|"inhibits"| PI3K
    AMPK -->|"inhibits"| mTOR
    TSC_complex -->|"inhibits"| mTOR
    mTOR -->|"inhibits"| autophagy
    mTOR -->|"phosphorylates"| ULK1
    mTOR -->|"inhibits"| TFEB
    ULK1 -->|"initiates"| autophagy
    TFEB -->|"promotes"| lysosomal_biogenesis
    mTOR -->|"regulates"| cell_growth
    mTOR -->|"regulates"| metabolism
    mTOR -->|"regulates"| aging
    rapamycin -->|"inhibits"| mTOR
    autophagy -->|"protects against"| neurodegeneration

    style mTOR fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style autophagy fill:#1b5e20
    style TFEB fill:#1b5e20
    style lysosomal_biogenesis fill:#1b5e20
    style rapamycin fill:#1b5e20
    style AMPK fill:#4a1a6b
    style PTEN fill:#4a1a6b
    style TSC_complex fill:#4a1a6b
    style neurodegeneration fill:#7d4200
    style aging fill:#ef5350

Outgoing (4253)

Target	Relation	Type	Str
TFEB	phosphorylates	protein	0.95
Protein Synthesis	modulates	process	0.95
Autophagy	modulates	process	0.95
Cell Growth	regulates	phenotype	0.95
Protein Synthesis	regulates	process	0.95
mRNA Translation	modulates	process	0.95
Cell Proliferation	regulates	process	0.95
PI3K/Akt/mTOR	involved_in	pathway	0.95
autophagy	inhibits	process	0.90
cell growth	regulates	phenotype	0.90
metabolism	regulates	phenotype	0.90
aging	regulates	phenotype	0.90
cell cycle progression	activates	phenotype	0.90
LC3	upstream_of	protein	0.90
Glioblastoma	associated_with	disease	0.90
neurological diseases	risk_factor_for	disease	0.90
Autophagy Initiation	activates	process	0.90
Metabolism	modulates	process	0.90
Autophagy	regulates	process	0.90
Alzheimer's disease severity	associated_with	phenotype	0.88
myeloma cell migration	promotes	process	0.85
AKT	downstream_of	protein	0.85
SREBP1	activates	protein	0.85
Cancer	associated_with	disease	0.85
Antidepressant Response	mediates	phenotype	0.82
lysosomal biogenesis	regulates	pathway	0.80
ULK1	phosphorylates	gene	0.80
rosacea	associated_with	disease	0.80
FOXO3	associated_with	gene	0.80
Apoptosis	regulates	process	0.80
Cellular Functions	regulates	process	0.80
Chrysotoxine	interacts_with	compound	0.80
ULK1	upstream_of	gene	0.80
Neurodegeneration	associated_with	disease	0.80
Metabolic Disorders	associated_with	disease	0.80
Ageing	associated_with	phenotype	0.80
Retinal Ganglion Cell Neuroprotection	involved_in	mechanism	0.80
autophagy_pathway	inhibits	pathway	0.72
autophagy	regulates	process	0.70
neurodegeneration	associated_with	disease	0.70
cancer	associated_with	disease	0.70
ageing	regulates	process	0.70
astrocyte transition	regulates	process	0.70
neuroinflammation	regulates	process	0.70
Alzheimer's disease	treats	disease	0.70
ULK1	regulates	protein	0.70
astrocyte neurotoxicity	regulates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
metabolic dysfunction	activates	process	0.70
tau hyperphosphorylation	activates	process	0.70

Incoming (5462)

Source	Relation	Type	Str
YB-3-17	inhibits	compound	0.95
rapamycin	inhibits	drug	0.90
AMPK	regulates	protein	0.90
TSC1-TSC2	inhibits	protein	0.90
everolimus	inhibits	drug	0.90
TSC1-TSC2 complex	inhibits	protein	0.90
paeoniflorin	inhibits	drug	0.90
AKT	activates	protein	0.90
AKT	upstream_of	protein	0.90
PI3K	downstream_of	protein	0.90
oleanonic acid	inhibits	drug	0.90
Baicalein	downregulates	compound	0.90
Sirolimus	inhibits	drug	0.90
G-quadruplex stabilizing ligands	downregulates	compound	0.90
Glutamine Metabolism	regulates	pathway	0.85
STAU2	activates	protein	0.85
NF-κB	interacts_with	pathway	0.85
Growth Factor Signals	activates	mechanism	0.85
Nutritional Status	regulates	phenotype	0.85
PI3K/AKT	activates	pathway	0.85
Akt	activates	protein	0.80
MAPK	regulates	protein	0.80
AMPK	interacts_with	protein	0.80
PI3K	activates	pathway	0.80
PTEN	inhibits	gene	0.80
ULK1	inhibits	gene	0.80
VSIG2	activates	protein	0.80
Alzheimer's Disease	associated_with	disease	0.80
Down Syndrome	associated_with	disease	0.80
Fluoride	downregulates	chemical	0.80
MIR-25-3P	activates	gene	0.80
TFAP2C	activates	transcription_factor	0.80
miR-217	downregulates	biomarker	0.80
AE	activates	compound	0.80
STAU1	interacts_with	gene	0.80
STAU1	regulates	gene	0.80
Starvation	regulates	phenotype	0.75
Growth Factors	regulates	compound	0.75
IDH1	activates	gene	0.75
VHL	activates	gene	0.75
growth factor signals	activates	process	0.70
NLRP3	activates	protein	0.70
SGLT2	regulates	protein	0.70
GSK-3	interacts_with	protein	0.70
traditional Chinese medicine	regulates	drug	0.70
TREM2	regulates	protein	0.70
Dectin-1	activates	protein	0.70
AMPK	inhibits	protein	0.70
Autophagy	interacts_with	entity	0.70
Rapamycin	activates	entity	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
REDD1-mTOR Axis as the Master Regulator — Preservation Over	0.586	neurodegeneration	Why does iron chelation therapy worsen o
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.451	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

neurodegeneration | 2026-04-11 | 0 hypotheses

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.510

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403]	Ye S, Wu C, Huang S, Fan H, Zhang Z et a	Genomics	2025	0

mTOR

Understanding Entity Pages

Wiki Pages (21)

MTOR (Redirect)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Therapeutics

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

nct07165106

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Growth Factor Therapies

ALS Failed Approaches Analysis

Mitochondrial Dysfunction in Parkinson's Disease

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes