concept

ISCHEMIC STROKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIC STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

286Connections

0Hypotheses

0Analyses

9Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ISCHEMIC STROKE
Key Genes/Proteins	STROKE, ALZHEIMER
Related Diseases	atherosclerosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ISCHEMIC_STROKE["ISCHEMIC STROKE"]
    style ISCHEMIC_STROKE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ISCHEMIC_STROKE -->|"causes"| Neuroinflammation["Neuroinflammation"]
    ISCHEMIC_STROKE -->|"causes"| Blood_Brain_Barrier_Disruption["Blood-Brain Barrier Disruption"]
    ISCHEMIC_STROKE -->|"upregulates"| IFI27L2A([IFI27L2A])
    ISCHEMIC_STROKE -->|"causes"| blood_brain_barrier_integrity["blood-brain barrier integrity"]
    ISCHEMIC_STROKE -->|"causes"| neuronal_cell_death["neuronal cell death"]
    ISCHEMIC_STROKE -->|"causes"| neuroinflammation["neuroinflammation"]
    Gnetupendin_A["Gnetupendin A"] -.->|"protects against"| ISCHEMIC_STROKE
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| ISCHEMIC_STROKE
    Triolein["Triolein"] -->|"treats"| ISCHEMIC_STROKE
    Tissue_Plasminogen_Activator{"Tissue Plasminogen Activator"} -->|"treats"| ISCHEMIC_STROKE
    Lipid_nanoparticles{"Lipid nanoparticles"} -->|"treats"| ISCHEMIC_STROKE
    Rehmannioside_A["Rehmannioside A"] -.->|"protects against"| ISCHEMIC_STROKE
    Excitotoxicity["Excitotoxicity"] -->|"contributes to"| ISCHEMIC_STROKE
    Remote_Ischemic_Conditioning["Remote Ischemic Conditioning"] -.->|"protects against"| ISCHEMIC_STROKE
    KLF11["KLF11"] -.->|"protects against"| ISCHEMIC_STROKE
    B_glomerulata{"B.glomerulata"} -->|"treats"| ISCHEMIC_STROKE

Outgoing (20)

Target	Relation	Type	Str
CENTRAL NERVOUS SYSTEM	causes	concept	0.50
NUCLEUS	associated_with	concept	0.50
MTOR SIGNALING	regulates	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50

Incoming (266)

Source	Relation	Type	Str
C1Q	associated_with	entity	0.90
STROKE	interacts_with	gene	0.50
ISCHEMIC	interacts_with	concept	0.50
atherosclerosis	interacts_with	disease	0.50
STROKE	inhibits	gene	0.50
ALZHEIMER	inhibits	gene	0.50
Alzheimer'S Disease	inhibits	disease	0.50
Hypertension	inhibits	disease	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
ISCHEMIC	inhibits	concept	0.50
STROKE	activates	gene	0.50
ISCHEMIC	activates	concept	0.50
STROKE	associated_with	gene	0.50
ISCHEMIC	associated_with	concept	0.50
MMP9	activates	gene	0.50
MMP2	activates	gene	0.50
microglia	activates	cell_type	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
ANXA1	associated_with	protein	0.50
microglia	associated_with	cell_type	0.50
STROKE	causes	gene	0.50
ISCHEMIA	causes	disease	0.50
ISCHEMIC	causes	concept	0.50
Myocardial Infarction	associated_with	disease	0.50
microglia	interacts_with	cell_type	0.50
CKLF1	interacts_with	concept	0.50
STROKE	expressed_in	gene	0.50
ISCHEMIC	expressed_in	concept	0.50
Proteins	expressed_in	protein	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
Pi3K/Akt	activates	pathway	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
Cerebrovascular	causes	pathway	0.50
disease	causes	disease	0.50
Neuroinflammation	interacts_with	process	0.50
RIPK3	interacts_with	gene	0.50
RIPK1	interacts_with	gene	0.50
RIPK2	interacts_with	gene	0.50
inflammation	interacts_with	pathway	0.50
ALZHEIMER	interacts_with	gene	0.50
PARKINSON	interacts_with	gene	0.50
amyotrophic lateral sclerosis	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
Parkinson's Disease	interacts_with	disease	0.50
MULTIPLE SCLEROSIS	interacts_with	disease	0.50
BRAIN INJURY	interacts_with	concept	0.50
Traumatic Brain Injury	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ISCHEMIC STROKE

Understanding Entity Pages

Wiki Pages (20)

Parthanatos in Neurodegeneration

amyloid-beta-metalloproteinases

Vascular Cognitive Impairment (VCI)

VEGF/Angiogenesis Pathway in Neurodegeneration

Astrocytes

Cerebral Small Vessel Disease

Blarcamesine

Necroptotic Neurons

vegfr-signaling-neurodegeneration

Excitotoxicity Pathway

Cerebral Ischemia Pathway in Neurodegeneration

blood-brain-barrier-endothelial-cells

MAPK9 Gene

Ferroptotic Neurons

Japanese Neurodegeneration Biotech Companies

FGF Signaling Pathway in Neurodegeneration

NIH Drug Repurposing Program for Neurodegenerative Diseases

Amiloride