concept

AKR1B10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKR1B10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

22Outgoing

6Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AKR1B10
Key Genes/Proteins	BCL2, BAX, LONP1
Related Diseases	hepatocellular carcinoma, Non-Alcoholic Fatty Liver Disease, Fibrosis, Cirrhosis, Hepatitis

Pathway Diagram

graph TD
    AKR1B10["AKR1B10"]
    AKR1B10 -->|"promotes"| hepatocellular_carcinoma["hepatocellular carcinoma"]
    AKR1B10 -->|"promotes"| HCC_cell_proliferation["HCC cell proliferation"]
    AKR1B10 -.biomarker for.-> Non_Alcoholic_Fatty_Liver_Dise["Non-Alcoholic Fatty Liver Disease"]
    AKR1B10 -->|"regulates"| BCL2["BCL2"]
    AKR1B10 -->|"regulates"| BAX["BAX"]
    AKR1B10 -->|"regulates"| LONP1["LONP1"]
    AKR1B10 -.biomarker for.-> Hepatitis["Hepatitis"]
    AKR1B10 -.biomarker for.-> Diabetes["Diabetes"]
    LONP1 -->|"downstream_of"| AKR1B10
    hepatic_stellate_cells["hepatic stellate cells"] -->|"regulates"| AKR1B10
    AND["AND"] -.biomarker for.-> AKR1B10
    RNA["RNA"] -->|"encodes"| AKR1B10
    TREM2["TREM2"] -.biomarker for.-> AKR1B10

Outgoing (22)

Target	Relation	Type	Str
hepatocellular carcinoma	promotes	disease	0.90
HCC cell proliferation	promotes	process	0.90
Non-Alcoholic Fatty Liver Disease	biomarker_for	disease	0.85
BCL2	regulates	gene	0.85
BAX	regulates	gene	0.85
LONP1	regulates	gene	0.80
Fibrosis	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Hepatitis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
ALS	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	encodes	disease	0.65
Als	encodes	disease	0.65
STEATOHEPATITIS	associated_with	disease	0.64
TREM2	biomarker_for	gene	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
RNA	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
TREM2	associated_with	gene	0.60
diabetes	associated_with	disease	0.60

Incoming (6)

Source	Relation	Type	Str
LONP1	downstream_of	gene	0.80
hepatic stellate cells	regulates	cell_type	0.75
RNA	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
RNA	encodes	gene	0.60
TREM2	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found