disease

diabetes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about diabetes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3248Connections

0Hypotheses

1Analyses

36Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	Akt, Insulin receptor, GLUT4, PPAR, MCU, LETM1, CERS2, AGER
Therapeutic Agents	spermidine, quercetin, lithium
KG Connections	229 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    diabetes["diabetes"] -->|"involves"| insulin_signaling["insulin signaling"]
    style insulin_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"affects"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"involves"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"disrupts"| mitochondria["mitochondria"]
    style mitochondria fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"affects"| neural_stem_cells["neural stem cells"]
    style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"associated"| periodontitis_severity["periodontitis severity"]
    style periodontitis_severity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"treats"| diabetes["diabetes"]
    style metformin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PI3K["PI3K"] -.->|"inhibits"| diabetes["diabetes"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SST["SST"] -->|"activates"| diabetes["diabetes"]
    style SST fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AMPK_SIRT1_PGC_1alpha_pathway["AMPK/SIRT1/PGC-1alpha pathway"] -->|"regulates"| diabetes["diabetes"]
    style AMPK_SIRT1_PGC_1alpha_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Akt["Akt"] -->|"associated"| diabetes["diabetes"]
    style Akt fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1088)

Target	Relation	Type	Str
insulin signaling	involves	pathway	0.90
endothelial cells	affects	cell_type	0.90
neurons	affects	cell_type	0.90
PI3K-AKT-mTOR signaling	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
periodontitis severity	associated_with	phenotype	0.85
lipid metabolism	involves	pathway	0.80
macrophages	affects	cell_type	0.80
NF-kB signaling	involves	pathway	0.80
unfolded protein response	involves	pathway	0.80
mitochondrial dynamics	involves	pathway	0.80
hippocampus	affects	brain_region	0.80
atherosclerosis	activates	disease	0.72
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
ferroptosis	involves	pathway	0.70
astrocytes	affects	cell_type	0.70
microglia	affects	cell_type	0.70
Alzheimer's disease	promotes	disease	0.70
pyroptosis	involves	pathway	0.60
necroptosis	involves	pathway	0.60
oligodendrocytes	affects	cell_type	0.60
Schwann cells	affects	cell_type	0.60
oxidative stress response	involves	pathway	0.60
autophagy pathway	involves	pathway	0.60
epigenetic regulation	involves	pathway	0.60
MAPK signaling	involves	pathway	0.60
apoptosis pathway	involves	pathway	0.60
purinergic signaling	involves	pathway	0.60
purinergic receptor	involves	receptor	0.60
monocytes	affects	cell_type	0.60
NMDA receptor	involves	receptor	0.60
serotonin	disrupts	neurotransmitter	0.60
substantia nigra	affects	brain_region	0.60
blood-brain barrier	affects	brain_region	0.60

Incoming (2160)

Source	Relation	Type	Str
PI3K	inhibits	gene	0.80
SST	activates	gene	0.80
SST	protects_against	gene	0.80
AMPK/SIRT1/PGC-1alpha pathway	regulates	pathway	0.70
Akt	associated_with	protein	0.70
Insulin receptor	associated_with	protein	0.70
altered metabolic activity	causes	process	0.70
RNA	regulates	gene	0.70
PI3K	activates	gene	0.70
AKT	inhibits	gene	0.70
quercetin	treats	compound	0.70
RAGE	associated_with	gene	0.70
TLR4	inhibits	gene	0.70
AKT	activates	gene	0.70
BACE1	implicated_in	gene	0.70
SIRT1	activates	gene	0.70
CLOCK	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
ROS	protects_against	gene	0.60
ROS	biomarker_for	gene	0.60
SIRT6	regulates	gene	0.60
SIRT6	treats	gene	0.60
TREM2	biomarker_for	gene	0.60
AMPK	activates	gene	0.60
AMPK	regulates	gene	0.60
spermidine	treats	compound	0.60
PI3K	causes	gene	0.60
C3	associated_with	gene	0.60
WNT	inhibits	gene	0.60
WNT	regulates	gene	0.60
HIF	activates	gene	0.60
RNA	activates	gene	0.60
RNA	protects_against	gene	0.60
GFAP	associated_with	gene	0.60
VEGF	inhibits	gene	0.60
VEGF	regulates	gene	0.60
PINK1	activates	gene	0.60
PINK1	treats	gene	0.60
AKT	protects_against	gene	0.60
PI3K	protects_against	gene	0.60
ROS	associated_with	gene	0.60
SST	associated_with	gene	0.60
ERK	activates	gene	0.60
JNK	activates	gene	0.60
ERK	treats	gene	0.60
JNK	treats	gene	0.60
MTNR1B	associated_with	gene	0.60
MLCK	inhibits	gene	0.60
JNK	inhibits	gene	0.60
MLCK	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

diabetes

Understanding Entity Pages

Wiki Pages (20)

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