SciDEX — Hepatocellular Carcinoma

graph TD
    Hepatocellular_Carcinoma["<b>Hepatocellular Carcinoma</b>"]
    Cancer{"Cancer"}
    Hepatocellular_Carcinoma -->|"associated_with"| Cancer
    Als{"Als"}
    Hepatocellular_Carcinoma -->|"therapeutic_target"| Als
    Carcinoma{"Carcinoma"}
    Hepatocellular_Carcinoma -->|"therapeutic_target"| Carcinoma
    Autophagy["Autophagy"]
    Hepatocellular_Carcinoma -->|"activates"| Autophagy
    CANCER(["CANCER"])
    CANCER -->|"associated_with"| Hepatocellular_Carcinoma
    GENES(["GENES"])
    GENES -->|"activates"| Hepatocellular_Carcinoma
    Tumor{"Tumor"}
    Tumor -->|"activates"| Hepatocellular_Carcinoma
    style Hepatocellular_Carcinoma fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (307)

Target	Relation	Type	Str
Cancer	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
Cancer	causes	disease	1.00
Carcinoma	associated_with	disease	1.00
Autophagy	activates	pathway	1.00
Carcinoma	activates	disease	1.00
Cancer	activates	disease	1.00
Ferroptosis	activates	pathway	1.00
Genomic Characterization	associated_with	process	0.95
Liver Cancer	associated_with	disease	0.95
Liver Cancer	therapeutic_target	disease	0.95
Carcinoma	causes	disease	0.95
Hepatitis	associated_with	disease	0.95
Multimodal Tumor Thermal Therapy	therapeutic_target	process	0.95
Cancer Genome	biomarker_for	biomarker	0.90
Integrative Analysis	associated_with	process	0.90
Metastasis	activates	pathway	0.90
Mtor	activates	pathway	0.90
Pi3K/Akt	activates	pathway	0.90
Inflammation	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Angiogenesis	involved_in	process	0.85
Lipid Metabolism	therapeutic_target	pathway	0.80
Glycolysis	activates	pathway	0.80
Autophagy	associated_with	pathway	0.80
Er Stress	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Nafld	therapeutic_target	disease	0.75
Fatty Liver	therapeutic_target	disease	0.75
Hepatitis	activates	disease	0.75
Cancer	inhibits	disease	0.75
Carcinoma	inhibits	disease	0.75
Als	inhibits	disease	0.75
Als	causes	disease	0.75
Tgf-Β	therapeutic_target	pathway	0.70
Mtor	treats	pathway	0.70
Cholesterol	therapeutic_target	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Glycolysis	inhibits	pathway	0.70
Wnt	therapeutic_target	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Invasion	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Mitophagy	associated_with	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Autophagy	implicated_in	pathway	0.70

Incoming (619)

Source	Relation	Type	Str
CANCER	associated_with	gene	1.00
CANCER	causes	gene	1.00
GENES	activates	gene	1.00
Tumor	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	inhibits	disease	1.00
CANCER	activates	gene	1.00
Tumor	associated_with	disease	1.00
Carcinoma	associated_with	disease	1.00
FERROPTOSIS	activates	gene	1.00
Cancer	activates	disease	1.00
Carcinoma	activates	disease	1.00
PI3K	activates	gene	1.00
AKT	activates	gene	1.00
Carcinoma	therapeutic_target	disease	1.00
Lactate	causes	compound	0.95
Nafld	contributes_to	disease	0.95
Cancer Genome Atlas Research Network	involved_in	process	0.95
CANCER	therapeutic_target	gene	0.95
STAT3	therapeutic_target	gene	0.95
INFLAMMATION	activates	gene	0.95
KEAP1	activates	gene	0.95
P62	activates	gene	0.95
NRF2	activates	gene	0.95
UBIQUITIN	activates	gene	0.95
STAT3	activates	gene	0.95
PTEN	activates	gene	0.95
Central Nervous System	modulates	process	0.95
Peripheral Nervous System	modulates	process	0.95
Nash	causes	disease	0.95
Genomic Alterations	associated_with	mechanism	0.95
AFP	biomarker_for	biomarker	0.95
GPC3	biomarker_for	biomarker	0.95
DCP	biomarker_for	biomarker	0.95
FDX1	downregulates	gene	0.95
TMX2	associated_with	gene	0.95
Britannin	inhibits	compound	0.95
Lactate	promotes	compound	0.95
PI3K/AKT/mTOR Signaling	regulates	pathway	0.95
Cx3Cr1+Gpr56+ T Cells	biomarker_for	cell_type	0.95
HDAC2	associated_with	gene	0.92
EGF-EGFR/CHKA/PI3K-PDK1-AKT Cascade	contributes_to	pathway	0.90
NAFLD-mSIII	risk_factor_for	phenotype	0.90
TERT	biomarker_for	gene	0.90
Tumor Suppressor Genes	associated_with	mechanism	0.90
ACVR2A	associated_with	gene	0.90
TRIM34	biomarker_for	gene	0.90
Apigenin	treats	compound	0.90
Ginsenoside RG3	treats	compound	0.90

Associated Genes	CANCER, AKT, PI3K, MTOR, P38, GPX4, ELAVL1, BECN1
Therapeutic Agents	Beta-blockers, SSRIs, Serotonin, HDAC2 Inhibitor, Apigenin, Ginsenoside RG3
KG Connections	673 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Hepatocellular Carcinoma

Understanding Entity Pages

Wiki Pages (20)

CLCN10 — Chloride Voltage-Gated Channel 10

MACF1 — Microtubule-actin crosslinking factor 1

GPT - Alanine Transaminase (ALT)

PDCD10 Gene (Programmed Cell Death 10)

TRIM32 Gene

Pathway Diagram

Outgoing (307)

Incoming (619)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

Hepatocellular Carcinoma

Understanding Entity Pages

Wiki Pages (20)

CLCN10 — Chloride Voltage-Gated Channel 10

MACF1 — Microtubule-actin crosslinking factor 1

GPT - Alanine Transaminase (ALT)

PDCD10 Gene (Programmed Cell Death 10)

TRIM32 Gene

TRIM3

can-fite-biopharma

HERC2 Gene

Ribosomal Protein S15a (RPS15A)

Gaucher Disease

WNT3 Gene

Biomarkers in Parkinsonian Syndromes (NCT06501469)

RPS5 — Ribosomal Protein S5

GOT1 Gene

DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1

Wilson's Disease Treatment

tmx2

MCC Gene

E2F5 Gene

Ephrin/Eph Receptor Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (307)

Incoming (619)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)