disease

FIBROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2398Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	CAV1, FOXO1, FUNDC1, GPX4, PIEZO2, PINK1, PPAR, PPARGC1A
Therapeutic Agents	SORAFENIB
KG Connections	455 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    FIBROSIS["FIBROSIS"] -->|"activates"| SLC7A11["SLC7A11"]
    style SLC7A11 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| BCL2["BCL2"]
    style BCL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style COLORECTAL_CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| EGFR["EGFR"]
    style EGFR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| CGAS["CGAS"]
    style CGAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| FOXO1["FOXO1"]
    style FOXO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    STEATOHEPATITIS["STEATOHEPATITIS"] -->|"activates"| FIBROSIS["FIBROSIS"]
    style STEATOHEPATITIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FERROPTOSIS["FERROPTOSIS"] -->|"regulates"| FIBROSIS["FIBROSIS"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    BECN1["BECN1"] -->|"interacts"| FIBROSIS["FIBROSIS"]
    style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FOXO1_1["FOXO1"] -->|"protects against"| FIBROSIS["FIBROSIS"]
    style FOXO1_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"regulates"| FIBROSIS["FIBROSIS"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style FIBROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (781)

Target	Relation	Type	Str
Apoptosis	therapeutic_target	pathway	1.00
Als	associated_with	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Cardiac	activates	disease	1.00
Als	treats	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Inflammation	inhibits	disease	1.00
Lipid Metabolism	activates	pathway	1.00
Epigenetic	therapeutic_target	pathway	1.00
Cancer	associated_with	disease	1.00
Autophagy	activates	pathway	1.00
Hepatitis	associated_with	disease	1.00
Apoptosis	activates	pathway	1.00
Inflammation	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	associated_with	disease	1.00
Diabetes	associated_with	disease	1.00
Inflammation	causes	disease	1.00
Inflammation	regulates	disease	1.00
Mitophagy	activates	pathway	1.00
Tgf-Β	regulates	pathway	1.00
Oxidative Stress	inhibits	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Apoptosis	regulates	pathway	1.00
Senescence	activates	pathway	1.00
Hepatitis	biomarker_for	disease	0.95
Inflammation	implicated_in	disease	0.95
Diabetes	therapeutic_target	disease	0.95
Hepatitis	therapeutic_target	disease	0.95
Carcinoma	therapeutic_target	disease	0.95
Cardiac	treats	disease	0.95
MACROPHAGES	activates	cell_type	0.95
Als	inhibits	disease	0.95
Interstitial Lung Diseases	causes	disease	0.90
Tgf-Β	therapeutic_target	pathway	0.90
Tgf-Β	activates	pathway	0.90
Autophagy	therapeutic_target	pathway	0.90
Tgf-Β	inhibits	pathway	0.90
Immune Response	activates	pathway	0.90
Ferroptosis	inhibits	pathway	0.90
Differentiation	activates	pathway	0.90
Lipid Metabolism	therapeutic_target	pathway	0.90
Mtor	activates	pathway	0.90
kidney function	suppresses	phenotype	0.87
Non-Alcoholic Fatty Liver Disease	contributes_to	disease	0.85
Inflammation	contributes_to	disease	0.85
Cardiac	inhibits	disease	0.85

Incoming (1617)

Source	Relation	Type	Str
IL-6	inhibits	gene	1.00
CANCER	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
CANCER	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	inhibits	gene	1.00
GENES	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
AKT	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
P62	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
DNA	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
GENES	associated_with	gene	1.00
MITOPHAGY	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Pulmonary Fibrosis	therapeutic_target	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
GENES	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	implicated_in	gene	1.00
INFLAMMATION	causes	gene	1.00
Cirrhosis	associated_with	disease	1.00
AUTOPHAGY	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
Pulmonary Fibrosis	activates	disease	1.00
AMPK	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AUTOPHAGY	therapeutic_target	gene	0.95
NF-ΚB	activates	gene	0.95
MTORC1	therapeutic_target	gene	0.95
Cancer	activates	disease	0.95
INSULIN RESISTANCE	therapeutic_target	gene	0.95
CAR-T Therapy	treats	drug	0.95
Interstitial Lung Diseases	associated_with	disease	0.95
GENES	treats	gene	0.95
INFLAMMATION	contributes_to	gene	0.95
AGING	therapeutic_target	gene	0.95
STAT3	inhibits	gene	0.95
AMPK	therapeutic_target	gene	0.95
ROS	activates	gene	0.95
BAX	inhibits	gene	0.95
NF-ΚB	inhibits	gene	0.95
NRF2	inhibits	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity