concept

AMS-17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMS-17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
4Outgoing
0Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameAMS-17
Key Genes/ProteinsTNF, IL1B
Related DiseasesDementia

Pathway Diagram

flowchart TD
    N0["AMS-17"]
    N1["NLRP3"]
    N0 -->|"inhibits"| N1
    N2["Cognitive Function"]
    N0 -->|"associated with"| N2
    N3["TNF"]
    N0 -->|"downregulates"| N3
    N4["IL1B"]
    N0 -->|"downregulates"| N4
    N5["Tnf-Alpha"]
    N0 -->|"downregulates"| N5
    N6["Il-1Beta"]
    N0 -->|"downregulates"| N6
    N7["IL-4"]
    N0 -->|"upregulates"| N7
    N8["Remyelination"]
    N0 -->|"promotes"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 protein
    class N2 phenotype
    class N3 protein
    class N4 protein
    class N5 protein
    class N6 protein
    class N7 protein
    class N8 process

Outgoing (11)

TargetRelationTypeStr
TNFdownregulatesprotein0.90
IL1Bdownregulatesprotein0.90
Dementiatreatsdisease0.85
Neuroinflammationsuppressesprocess0.85

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found