disease

Vascular Dementia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Vascular Dementia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

1Analyses

36Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	TFR1, ALZHEIMER'S DISEASE, GPX4, ALZHEIMER, FERROPTOSIS, DEMENTIA, TAU, AND
Therapeutic Agents	Ams-17, Tong-Qiao-Huo-Xue Decoction, PAL
KG Connections	171 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| Tau_Protein_Hyperphosphorylati["Tau Protein Hyperphosphorylation"]
    style Tau_Protein_Hyperphosphorylati fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| Blood_Brain_Barrier_Dysfunctio["Blood-Brain Barrier Dysfunction"]
    style Blood_Brain_Barrier_Dysfunctio fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| Vitamin_D["Vitamin D"]
    style Vitamin_D fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| Ferroptosis["Ferroptosis"]
    style Ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"causes"| Cerebrovascular["Cerebrovascular"]
    style Cerebrovascular fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Vascular_Dementia["Vascular Dementia"] -->|"associated"| Amyloid["Amyloid"]
    style Amyloid fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"causes"| Vascular_Dementia["Vascular Dementia"]
    style Chronic_Cerebral_Hypoperfusion fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Tong_Qiao_Huo_Xue_Decoction["Tong-Qiao-Huo-Xue Decoction"] -->|"treats"| Vascular_Dementia["Vascular Dementia"]
    style Tong_Qiao_Huo_Xue_Decoction fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Cerebrovascular_Disease["Cerebrovascular Disease"] -->|"risk factor for"| Vascular_Dementia["Vascular Dementia"]
    style Cerebrovascular_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_1["NLRP3"] -->|"contributes to"| Vascular_Dementia["Vascular Dementia"]
    style NLRP3_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Ams_17["Ams-17"] -->|"treats"| Vascular_Dementia["Vascular Dementia"]
    style Ams_17 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style Vascular_Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (47)

Target	Relation	Type	Str
Tau Protein Hyperphosphorylation	associated_with	mechanism	0.90
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
NLRP3	associated_with	protein	0.85
Vitamin D	associated_with	chemical	0.70
Ferroptosis	associated_with	pathway	0.55
Cerebrovascular	causes	pathway	0.55
Amyloid	associated_with	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Myelination	inhibits	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Inflammasome	inhibits	pathway	0.55
Blood-Brain Barrier	inhibits	pathway	0.55
Apoptosis	activates	pathway	0.55
Dendritic Spine	activates	pathway	0.55
Camp Signaling	activates	pathway	0.55
Amyloid	inhibits	pathway	0.55
Calcium Signaling	expressed_in	pathway	0.55
Blood-Brain Barrier	causes	pathway	0.55
Cerebrovascular	associated_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Amyloid	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Sod1	interacts_with	pathway	0.55
Oligodendrocyte	interacts_with	cell_type	0.55
Opc	interacts_with	cell_type	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Endothelial	therapeutic_target	cell_type	0.55
Inflammasome	therapeutic_target	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Neuron	activates	cell_type	0.55
Neuron	therapeutic_target	cell_type	0.55
Endothelial	associated_with	cell_type	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
White Matter	associated_with	brain_region	0.50
Hippocampus	associated_with	brain_region	0.50
Cortex	associated_with	brain_region	0.50

Incoming (169)

Source	Relation	Type	Str
Chronic Cerebral Hypoperfusion	causes	process	0.95
Tong-Qiao-Huo-Xue Decoction	treats	drug	0.95
Chronic Cerebral Hypoperfusion	contributes_to	disease	0.90
Cerebrovascular Disease	risk_factor_for	disease	0.90
NLRP3	contributes_to	protein	0.90
Ams-17	treats	compound	0.85
Oligodendrocytes	involved_in	cell_type	0.85
PAL	treats	compound	0.85
A3AR	treats	receptor	0.80
TNF-α	biomarker_for	protein	0.80
Ferroptosis	accelerates	process	0.80
TFR1	causes	gene	0.65
ALZHEIMER'S DISEASE	causes	gene	0.65
GPX4	causes	gene	0.65
ALZHEIMER	causes	gene	0.65
FERROPTOSIS	associated_with	gene	0.65
DEMENTIA	causes	gene	0.65
TAU	causes	gene	0.65
OLIGODENDROCYTE	interacts_with	gene	0.65
LRP1	interacts_with	gene	0.65
AND	causes	gene	0.65
SERPINE2	interacts_with	gene	0.65
RNA	interacts_with	gene	0.65
AND	interacts_with	gene	0.65
CD39	interacts_with	gene	0.65
AGING	associated_with	gene	0.65
NEURODEGENERATION	activates	gene	0.65
DEMENTIA	associated_with	gene	0.65
ALZHEIMER DISEASE	associated_with	gene	0.65
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.65
ALZHEIMER	associated_with	gene	0.65
AND	associated_with	gene	0.65
AMYLOID	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.65
NEURODEGENERATION	inhibits	gene	0.65
NEUROINFLAMMATION	inhibits	gene	0.65
DEMENTIA	contributes_to	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	gene	0.65
TNF	inhibits	gene	0.65
ALZHEIMER	contributes_to	gene	0.65
PARKINSON	contributes_to	gene	0.65
IL-4	inhibits	gene	0.65
AND	contributes_to	gene	0.65
ALZHEIMER'S DISEASE	contributes_to	gene	0.65
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.65
STROKE	contributes_to	gene	0.65
APOPTOSIS	inhibits	gene	0.65
PARKINSON'S DISEASE	contributes_to	gene	0.65
ALS	contributes_to	gene	0.65
TNF-Α	inhibits	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Vascular Dementia

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

calcium-dysregulation-comparison

Therapeutics

Alzheimer's Disease

p-tau-217

Growth Factor Therapies

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

Vascular Cognitive Impairment (VCI)

VEGF/Angiogenesis Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

Charité - Universitätsmedizin Berlin

Cerebrospinal Fluid (CSF) Biomarkers Overview

rankings

Growth Factor Therapeutics: Investment Landscape Analysis

neurovascular-coupling

university-michigan

NF-kB Signaling Pathway in Neurodegeneration

Cerebral Small Vessel Disease