gene

ape2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ape2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
12Outgoing
2Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolAPE2
Chromosome6p25.2
Protein TypeGene
Functionis a DNA repair enzyme belonging to the DNA repair endonuclease family.
Primary Expressionall tissues, with high expression in: - Brain: neurons, astrocytes, microglia - Hea
Molecular Weight56 kDa
Amino Acids517 aa
GeneCardsAPE2
Human Protein AtlasAPE2
Associated Diseasescancer, neurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

ATG4A Protein

protein · 1091 words

APE2 Gene

gene · 643 words

APE2 Protein

protein · 543 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["APE2"]
    N1["ATR"]
    N0 -->|"participates in"| N1
    N2["Chk1"]
    N0 -->|"participates in"| N2
    N3["MYH9"]
    N0 -->|"binds"| N3
    N4["DNA repair"]
    N0 -->|"participates in"| N4
    N5["DNA damage response"]
    N0 -->|"participates in"| N5
    N6["Hsp70"]
    N0 -->|"binds"| N6
    N7["Hsp90"]
    N0 -->|"binds"| N7
    N8["PCNA"]
    N0 -->|"binds"| N8
    N9["cancer"]
    N0 -->|"associated with"| N9
    N10["MKRN3"]
    N10 -->|"catalyzes"| N0
    N11["neurodegeneration"]
    N0 -->|"implicated in"| N11

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 protein
    class N2 protein
    class N3 protein
    class N6 protein
    class N7 protein
    class N8 protein
    class N9 disease
    class N10 gene

Outgoing (12)

TargetRelationTypeStr
ATRparticipates_inprotein0.90
Chk1participates_inprotein0.90
DNA repairparticipates_inbiological_process0.90
DNA damage responseparticipates_inbiological_process0.90
MYH9bindsprotein0.90

Incoming (2)

SourceRelationTypeStr
MKRN3catalyzesgene0.80
benchmark_ot_ad_answer_key:APE2data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found