Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ape2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APE2 |
| Chromosome | 6p25.2 |
| Protein Type | Gene |
| Function | is a DNA repair enzyme belonging to the DNA repair endonuclease family. |
| Primary Expression | all tissues, with high expression in: - Brain: neurons, astrocytes, microglia - Hea |
| Molecular Weight | 56 kDa |
| Amino Acids | 517 aa |
| GeneCards | APE2 |
| Human Protein Atlas | APE2 |
| Associated Diseases | cancer, neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["APE2"]
N1["ATR"]
N0 -->|"participates in"| N1
N2["Chk1"]
N0 -->|"participates in"| N2
N3["MYH9"]
N0 -->|"binds"| N3
N4["DNA repair"]
N0 -->|"participates in"| N4
N5["DNA damage response"]
N0 -->|"participates in"| N5
N6["Hsp70"]
N0 -->|"binds"| N6
N7["Hsp90"]
N0 -->|"binds"| N7
N8["PCNA"]
N0 -->|"binds"| N8
N9["cancer"]
N0 -->|"associated with"| N9
N10["MKRN3"]
N10 -->|"catalyzes"| N0
N11["neurodegeneration"]
N0 -->|"implicated in"| N11
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 protein
class N2 protein
class N3 protein
class N6 protein
class N7 protein
class N8 protein
class N9 disease
class N10 gene| Target | Relation | Type | Str |
|---|---|---|---|
| ATR | participates_in | protein | 0.90 |
| Chk1 | participates_in | protein | 0.90 |
| DNA repair | participates_in | biological_process | 0.90 |
| DNA damage response | participates_in | biological_process | 0.90 |
| MYH9 | binds | protein | 0.90 |
| Hsp70 | binds | protein | 0.80 |
| Hsp90 | binds | protein | 0.80 |
| Chk1 | binds | protein | 0.80 |
| cancer | associated_with | disease | 0.80 |
| PCNA | binds | protein | 0.80 |
| Prz1 | regulates | transcription_factor | 0.70 |
| benchmark_ot_ad_answer_key:APE2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MKRN3 | catalyzes | gene | 0.80 |
| benchmark_ot_ad_answer_key:APE2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||