Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Dna Repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Dna Repair is a biological pathway involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 355 entities in the SciDEX knowledge graph.
| Name | Dna Repair |
| Key Genes/Proteins | P53, DNA, CANCER, APOPTOSIS |
| Related Diseases | Cancer, Als |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
CGAS["CGAS"] -->|"activates"| Dna_Repair["Dna Repair"]
IRF3["IRF3"] -->|"activates"| Dna_Repair["Dna Repair"]
MAX["MAX"] -->|"activates"| Dna_Repair["Dna Repair"]
PARP1["PARP1"] -->|"activates"| Dna_Repair["Dna Repair"]
style Dna_Repair fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Frontotemporal Dementia | associated_with | disease | 0.85 |
| BREAST CANCER | regulates | disease | 0.50 |
| Reactive Oxygen Species | regulates | process | 0.50 |
| DNA DAMAGE | associated_with | concept | 0.50 |
| GENETIC MODIFIERS | interacts_with | concept | 0.50 |
| PI3K/AKT/mTOR | associated_with | pathway | 0.50 |
| BREAST CANCER | associated_with | disease | 0.50 |
| HOMOLOGOUS RECOMBINATION | activates | concept | 0.50 |
| CELL DEATH | inhibits | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| SRPK1 | interacts_with | concept | 0.50 |
| Ovarian Cancer | inhibits | disease | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| HUNTINGTON'S | associated_with | concept | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Neuron | therapeutic_target | cell_type | 0.50 |
| Macrophage | biomarker_for | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| T Cell | therapeutic_target | cell_type | 0.50 |
| T Cell | expressed_in | cell_type | 0.50 |
| Epithelial | activates | cell_type | 0.50 |
| T Cell | associated_with | cell_type | 0.50 |
| Microglia | associated_with | cell_type | 0.50 |
| Neuron | causes | cell_type | 0.50 |
| Macrophage | causes | cell_type | 0.50 |
| Neuron | contributes_to | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| P53 | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Senescence | regulates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | associated_with | disease | 0.95 |
| Tumor | inhibits | disease | 0.95 |
| Circadian Clock | modulates | process | 0.95 |
| DNA | therapeutic_target | gene | 0.90 |
| DNA | implicated_in | gene | 0.90 |
| Tumor | implicated_in | disease | 0.90 |
| Tumor | therapeutic_target | disease | 0.90 |
| GENES | therapeutic_target | gene | 0.90 |
| DNA | causes | gene | 0.90 |
| OXIDATIVE STRESS | activates | gene | 0.90 |
| CANCER | implicated_in | gene | 0.90 |
| Cancer | implicated_in | disease | 0.90 |
| Als | associated_with | disease | 0.85 |
| PSME2 | correlates_with | gene | 0.85 |
| GENES | regulates | gene | 0.80 |
| DNA | contributes_to | gene | 0.80 |
| APOPTOSIS | activates | gene | 0.80 |
| TP53 | implicated_in | gene | 0.80 |
| Als | implicated_in | disease | 0.80 |
| AGING | activates | gene | 0.80 |
| Aging | activates | disease | 0.80 |
| Senescence | inhibits | disease | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.80 |
| DNA | expressed_in | gene | 0.80 |
| GENES | associated_with | gene | 0.80 |
| GENES | activates | gene | 0.80 |
| Tumor | activates | disease | 0.75 |
| Tumor | regulates | disease | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Oligodendrocyte DNA Repair Enhancement Therapy | 0.462 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| Oligodendrocyte DNA Repair Enhancement | 0.378 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544] | Köcher S, Elsesy ME, Moustafa A, Mohamma | J Clin Invest | 2026 | 0 |
| Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453] | Shao B, Yin H, Zhang S, He S, Lu H et al | Cancer Genet | 2026 | 0 |
| Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852] | Liu J, Gonzalez-Hunt CP, Richbourg T, Ba | bioRxiv : the preprint server | 2026 | 0 |
| PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038] | Dumoulin I, Lee BJ, Zhang C, Lin X, Wang | bioRxiv | 2026 | 0 |
| Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005] | Wan Z, Li X, Wang Y, Miao S, Chen Z et a | Insects | 2026 | 0 |
| Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367] | Dauben H, Mihaljević M, Kolvenbach A, Pa | Nat Commun | 2026 | 0 |