Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATR is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.
| Gene Symbol | ATR |
| Protein Type | Kinase |
| Function | encodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011]. |
| Pathways | mTOR, mtor, mTOR signaling, PI3K |
| GeneCards | ATR |
| Human Protein Atlas | ATR |
| CHK1 | Checkpoint enforcement, cell cycle arrest |
| RPA2 | Replication fork stabilization |
| p53 | Transcription regulation, apoptosis |
| FANCE | Fanconi anemia pathway |
| SMARCAL1 | Fork remodeling |
| Compound | Mechanism |
| VE-822 (VX-970) | ATR inhibitor |
| AZD6738 | ATR inhibitor |
| ETP-46464 | ATR inhibitor |
| Associated Diseases | Als, Ataxia, Cancer, Infection, Ms, Senescence |
| Known Drugs/Compounds | rapamycin |
| Interactions | RAD51, BAX, RAD54, VCP, FNDC5, EZH2 |
| KG Connections | 212 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
APE2["APE2"] -->|"participates in"| ATR["ATR"]
ATM["ATM"] -->|"interacts with"| ATR["ATR"]
ATR["ATR"] -->|"activates"| Fibrosis["Fibrosis"]
ATR["ATR"] -->|"associated with"| Cancer["Cancer"]
ATR["ATR"] -->|"associated with"| Als["Als"]
ATR["ATR"] -->|"associated with"| Ataxia["Ataxia"]
ATR["ATR"] -->|"activates"| Cardiac["Cardiac"]
ATR["ATR"] -->|"associated with"| Ms["Ms"]
ATR["ATR"] -->|"regulates"| Aging["Aging"]
ATR["ATR"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
ATR["ATR"] -->|"regulates"| Als["Als"]
ATR["ATR"] -->|"regulates"| Cancer["Cancer"]
style APE2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ATR fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ATM fill:#006494,stroke:#333,color:#e0e0e0
style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| RFWD3 | phosphorylates | gene | 0.85 |
| Als | regulates | disease | 0.75 |
| Tumor | regulates | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| CANCER | inhibits | gene | 0.70 |
| Fibrosis | activates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Cardiac | activates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Longevity | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Ataxia | regulates | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Breast Cancer | inhibits | disease | 0.65 |
| Senescence | implicated_in | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Senescence | contributes_to | disease | 0.65 |
| ATM | associated_with | gene | 0.60 |
| RAD51 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| RAD54 | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| FNDC5 | activates | gene | 0.60 |
| HNRNPH1 | regulates | gene | 0.60 |
| BRCA2 | regulates | gene | 0.60 |
| ATM | regulates | gene | 0.60 |
| ATM | therapeutic_target | gene | 0.60 |
| EZH2 | inhibits | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| BRCA1 | inhibits | gene | 0.60 |
| ATM | inhibits | gene | 0.60 |
| SMAC | activates | gene | 0.60 |
| BID | regulates | gene | 0.60 |
| H2AX | regulates | gene | 0.60 |
| MRE11 | associated_with | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| CHEK1 | associated_with | gene | 0.60 |
| CHMP6 | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APE2 | participates_in | gene | 0.90 |
| ATM | interacts_with | protein | 0.70 |
| RAD54 | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| RAD51 | activates | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| FNDC5 | activates | gene | 0.60 |
| SIRT6 | regulates | gene | 0.60 |
| PARP1 | regulates | gene | 0.60 |
| HNRNPA1 | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| DDX5 | regulates | gene | 0.60 |
| PIN1 | regulates | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| SMAC | activates | gene | 0.60 |
| BID | regulates | gene | 0.60 |
| H2AX | regulates | gene | 0.60 |
| ATM | phosphorylates | gene | 0.60 |
| ARID1A | inhibits | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| ATM | regulates | gene | 0.60 |
| NBN | associated_with | gene | 0.60 |
| TPX2 | inhibits | gene | 0.60 |
| ATM | inhibits | gene | 0.60 |
| MDC1 | associated_with | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| TIGAR | inhibits | gene | 0.60 |
| FANCC | interacts_with | gene | 0.60 |
| FANCA | interacts_with | gene | 0.60 |
| FANCE | interacts_with | gene | 0.60 |
| AIM2 | contributes_to | gene | 0.60 |
| ATM | cleaves | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| P53 | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| KRAS | regulates | gene | 0.60 |
| APOPTOSIS | implicated_in | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| RFWD3 | activates | gene | 0.60 |
| MCM8 | activates | gene | 0.60 |
| AND | phosphorylates | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| DNA | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Matrix Stiffness Normalization via Targeted Lysyl Oxidase In | 0.515 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Extracellular Matrix Stiffness Modulation | 0.427 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720] | Harraz OF, Hashad AM | Physiology (Bethesda) | 2026 | 1 |
| Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690] | Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G | Fish Shellfish Immunol | 2025 | 1 |
| Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284] | Xu Q, Ma L, Streuer A, Altrock E, Schmit | Cell Commun Signal | 2025 | 1 |
| Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160] | Wang Y, Wang J, Zhang J, Wang Y, Wang Y, | Sci Adv | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296] | Jiang Y, Zhang H, Wang J, Liu Y, Luo T, | J Hematol Oncol | 2022 | 1 |
| Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671] | Atcha H, Jairaman A, Holt JR, Meli VS, N | Nat Commun | 2021 | 1 |
| Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920] | Sun H, Wu Z, Zhang Y, Liu C, Gao D et al | Osteoarthritis Cartilage | 2026 | 0 |
| Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513] | Ma J, Xie N, Wang Z, Liang X, Han Y et a | Adv Sci (Weinh) | 2026 | 0 |
| Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798] | Zhang M, Ge Y, Wang Z, Li H, Wang G et a | Neurosci Biobehav Rev | 2026 | 0 |
| Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045] | Pillai EK, Mukherjee S, Gampl N, McGinn | Nat Mater | 2026 | 0 |
| The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354] | Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a | MedComm (2020) | 2026 | 0 |
| Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for All [PMID:41933910] | Wolters A, Signorelli L, Herff C, Gimple | Adv Sci (Weinh) | 2026 | 0 |
| A 3D-Printed Pulsatile Shear Stress Platform for Studying Endothelial Cell Mecha [PMID:41949555] | Romanov V, Li JV, Zhao F, Cheng D, Marti | Anal Chem | 2026 | 0 |
| Piezo channels in tumors. [PMID:41964669] | Zhang W, Dai L, Shi H | J Cancer Res Clin Oncol | 2026 | 0 |
| Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] | ["Li R", "Xia J", "Shi C", "Zhang K", "Q | Journal of advanced research | 2026 | 0 |
| Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938] | Wang H, Gou Z, Chen S, Lu L | The International journal of n | 2026 | 0 |
| Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] | Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li | Frontiers in molecular bioscie | 2025 | 0 |
| PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] | Gupta T, Singh TG, Singh R | Molecular biology reports | 2025 | 0 |
| Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked [PMID:40465757] | ["Ventura-Antunes L", "Nackenoff A", "Ro | Alzheimer's & dementia : the j | 2025 | 0 |