gene

ATR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections
2Hypotheses
5Analyses
50Outgoing
50Incoming

Summary

ATR is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolATR
Protein TypeKinase
Functionencodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011].
PathwaysmTOR, mtor, mTOR signaling, PI3K
GeneCardsATR
Human Protein AtlasATR
CHK1Checkpoint enforcement, cell cycle arrest
RPA2Replication fork stabilization
p53Transcription regulation, apoptosis
FANCEFanconi anemia pathway
SMARCAL1Fork remodeling
CompoundMechanism
VE-822 (VX-970)ATR inhibitor
AZD6738ATR inhibitor
ETP-46464ATR inhibitor
Associated DiseasesAls, Ataxia, Cancer, Infection, Ms, Senescence
Known Drugs/Compoundsrapamycin
InteractionsRAD51, BAX, RAD54, VCP, FNDC5, EZH2
KG Connections212 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

ATR Gene

gene · 1682 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

NPM1 Gene

gene · 5653 words

TYNDASE — Tyndall

gene · 3964 words

DNA Damage Response in Corticobasal Syndrome

mechanism · 3900 words

DNA Damage Response Impairment Pathway

mechanism · 3871 words

Pathway Diagram

flowchart TD
    APE2["APE2"] -->|"participates in"| ATR["ATR"]
    ATM["ATM"] -->|"interacts with"| ATR["ATR"]
    ATR["ATR"] -->|"activates"| Fibrosis["Fibrosis"]
    ATR["ATR"] -->|"associated with"| Cancer["Cancer"]
    ATR["ATR"] -->|"associated with"| Als["Als"]
    ATR["ATR"] -->|"associated with"| Ataxia["Ataxia"]
    ATR["ATR"] -->|"activates"| Cardiac["Cardiac"]
    ATR["ATR"] -->|"associated with"| Ms["Ms"]
    ATR["ATR"] -->|"regulates"| Aging["Aging"]
    ATR["ATR"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ATR["ATR"] -->|"regulates"| Als["Als"]
    ATR["ATR"] -->|"regulates"| Cancer["Cancer"]
    style APE2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ATR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ATM fill:#006494,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (146)

TargetRelationTypeStr
RFWD3phosphorylatesgene0.85
Alsregulatesdisease0.75
Tumorregulatesdisease0.75
Cancerinhibitsdisease0.75
CANCERinhibitsgene0.70

Incoming (66)

SourceRelationTypeStr
APE2participates_ingene0.90
ATMinteracts_withprotein0.70
RAD54activatesgene0.60
VCPactivatesgene0.60
RAD51activatesgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In 0.515 neurodegeneration Perivascular spaces and glymphatic clear
Extracellular Matrix Stiffness Modulation 0.427 neurodegeneration Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (5)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720] Harraz OF, Hashad AM Physiology (Bethesda) 2026 1
Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690] Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G Fish Shellfish Immunol 2025 1
Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284] Xu Q, Ma L, Streuer A, Altrock E, Schmit Cell Commun Signal 2025 1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160] Wang Y, Wang J, Zhang J, Wang Y, Wang Y, Sci Adv 2024 1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] Zong B, Yu F, Zhang X, Pang Y, Zhao W, S Ageing Res Rev 2023 1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296] Jiang Y, Zhang H, Wang J, Liu Y, Luo T, J Hematol Oncol 2022 1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671] Atcha H, Jairaman A, Holt JR, Meli VS, N Nat Commun 2021 1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920] Sun H, Wu Z, Zhang Y, Liu C, Gao D et al Osteoarthritis Cartilage 2026 0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513] Ma J, Xie N, Wang Z, Liang X, Han Y et a Adv Sci (Weinh) 2026 0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798] Zhang M, Ge Y, Wang Z, Li H, Wang G et a Neurosci Biobehav Rev 2026 0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045] Pillai EK, Mukherjee S, Gampl N, McGinn Nat Mater 2026 0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354] Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a MedComm (2020) 2026 0
Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for All [PMID:41933910] Wolters A, Signorelli L, Herff C, Gimple Adv Sci (Weinh) 2026 0
A 3D-Printed Pulsatile Shear Stress Platform for Studying Endothelial Cell Mecha [PMID:41949555] Romanov V, Li JV, Zhao F, Cheng D, Marti Anal Chem 2026 0
Piezo channels in tumors. [PMID:41964669] Zhang W, Dai L, Shi H J Cancer Res Clin Oncol 2026 0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] ["Li R", "Xia J", "Shi C", "Zhang K", "Q Journal of advanced research 2026 0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938] Wang H, Gou Z, Chen S, Lu L The International journal of n 2026 0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li Frontiers in molecular bioscie 2025 0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] Gupta T, Singh TG, Singh R Molecular biology reports 2025 0
Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked [PMID:40465757] ["Ventura-Antunes L", "Nackenoff A", "Ro Alzheimer's & dementia : the j 2025 0