Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CHK1 |
| Key Genes/Proteins | SIRT1 |
| Related Diseases | Cardiac Dysfunction, Myocardial Ischemia-Reperfusion Injury, Cardiomyocyte Survival, Mitochondrial Dysfunction |
Knowledge base pages for this entity
graph TD
CHK1["CHK1"]
CHK1 -.protects against.-> Cardiac_Dysfunction["Cardiac Dysfunction"]
CHK1 -->|"interacts"| SIRT1["SIRT1"]
CHK1 -->|"inhibits"| SMURF2_mediated_SIRT1_Degradat["SMURF2-mediated SIRT1 Degradation"]
CHK1 -.protects against.-> Myocardial_Ischemia_Reperfusio["Myocardial Ischemia-Reperfusion Injury"]
CHK1 -->|"inhibits"| Cardiomyocyte_Apoptosis["Cardiomyocyte Apoptosis"]
CHK1 -->|"promotes"| Cardiomyocyte_Survival["Cardiomyocyte Survival"]
CHK1 -->|"promotes"| Mitochondrial_Biogenesis["Mitochondrial Biogenesis"]
APE2["APE2"] -->|"participates in"| CHK1
SIRT1 -->|"mediates"| CHK1
MITOPHAGY["MITOPHAGY"] -->|"activates"| CHK1
APOPTOSIS["APOPTOSIS"] -->|"activates"| CHK1
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"inhibits"| CHK1
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"inhibits"| CHK1| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiac Dysfunction | protects_against | phenotype | 0.95 |
| SIRT1 | interacts_with | protein | 0.95 |
| Myocardial Ischemia-Reperfusion Injury | protects_against | disease | 0.90 |
| SIRT1 | phosphorylates | protein | 0.90 |
| SMURF2-mediated SIRT1 Degradation | inhibits | process | 0.90 |
| Cardiomyocyte Apoptosis | inhibits | process | 0.90 |
| Cardiomyocyte Survival | promotes | phenotype | 0.90 |
| Oxidative Stress | associated_with | process | 0.88 |
| Mitochondrial Biogenesis | promotes | process | 0.87 |
| Mitophagy | promotes | process | 0.87 |
| Oxidative Stress | inhibits | process | 0.85 |
| Mitochondrial Biogenesis | associated_with | process | 0.85 |
| Mitophagy | associated_with | process | 0.85 |
| Mitochondrial Dysfunction | suppresses | phenotype | 0.85 |
| AMBRA1-deficient tumors | treats | disease | 0.70 |
| SIRT1 | suppresses_ubiquitination | protein | 0.70 |
| cardiac dysfunction | attenuates | disease | 0.70 |
| Ischemia | inhibits | disease | 0.65 |
| Cardiomyopathy | activates | disease | 0.65 |
| Mitophagy | activates | pathway | 0.60 |
| Mitochondrial Function | associated_with | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Cardiomyocyte | inhibits | cell_type | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| Ubiquitin | inhibits | protein | 0.60 |
| Rb | activates | protein | 0.60 |
| Fus | inhibits | protein | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| SIRT1 | targets | gene | 0.60 |
| ROS | associated_with | gene | 0.60 |
| SIRT1 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | mediates | protein | 0.88 |
| MITOPHAGY | activates | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| ROS | associated_with | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| OXIDATIVE STRESS | inhibits | gene | 0.60 |
| ROS | stabilizes | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| AGER | associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||