protein

HSP70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1149Connections

1Hypotheses

7Analyses

50Outgoing

50Incoming

Summary

HSP70 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 481 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HSPA1A
Full Name	Heat Shock Protein Family A (Hsp70) Member 1A/1B
Aliases	HSP70
Chromosome	6p21.33 (HSPA1A), 6p21.33 (HSPA1B)
Protein Family	Heat shock protein 70 family (HSP70 superfamily)
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cytoplasm, nucleus (stress-induced)
Molecular Weight	70 kDa
Amino Acids	640 aa
Pathways	Akt, Apoptosis, Chaperone, Complement, Epithelial-Mesenchymal Transition
UniProt ID	P0DMV8
OMIM	140100
GeneCards	HSPA1A
Human Protein Atlas	HSPA1A
Associated Diseases	ALS, Alzheimer, Cancer, Lung Cancer, Ms
Known Drugs/Compounds	tRNA, 5S rRNA, Trna, 5S Rrna, Non-Coding Rna, aducanumab
Interactions	TFE3, MAP1LC3A, MLKL, DEPTOR, HMGB1, EGF
KG Connections	1134 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSP70 — AlphaFold P0DMV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HSP70(["HSP70"])
    Nf__b["Nf-Kappab"]
    NF__B(["NF-KappaB"])
    Inflammation["Inflammation"]
    Als["Als"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Cancer["Cancer"]
    Apoptosis["Apoptosis"]
    poly_GA_aggregates("poly-GA aggregates")
    Oxidative_Stress["Oxidative Stress"]
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    UBQLN2(["UBQLN2"])
    TIA1(["TIA1"])
    PI3K(["PI3K"])

    HSP70 -->|"regulates"| Nf__b
    NF__B -->|"regulates"| HSP70
    HSP70 -->|"activates"| Inflammation
    HSP70 -->|"activates"| Als
    HSP70 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HSP70 -->|"regulates"| Cancer
    HSP70 -->|"regulates"| Apoptosis
    HSP70 -->|"activates"| poly_GA_aggregates
    HSP70 -->|"therapeutic target"| Apoptosis
    HSP70 -->|"therapeutic target"| Oxidative_Stress
    HSP70 -->|"activates"| Apoptosis
    HSP70 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    UBQLN2 -->|"interacts with"| HSP70
    TIA1 -.->|"inhibits"| HSP70
    PI3K -->|"regulates"| HSP70

    style HSP70 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (699)

Target	Relation	Type	Str
Non-coding RNA	binds	process	0.95
Trna	binds	compound	0.95
5S Rrna	binds	compound	0.95
Non-Coding Rna	interacts_with	compound	0.95
tRNA	binds	compound	0.92
5S rRNA	binds	compound	0.92
AIMP2-DX2	regulates	protein	0.90
RNA Polymerase III	regulates	enzyme	0.90
Rna Polymerase Iii	regulates	protein	0.90
Trna Gene Transcription	modulates	process	0.90
Non-Coding Rna Biogenesis	involved_in	process	0.90
tRNA Gene Transcription	upregulates	process	0.88
SIAH1	inhibits	protein	0.85
AIMP2-DX2	co_expressed_with	protein	0.85
Protein Homeostasis	involved_in	process	0.85
UBQLN2	interacts_with	gene	0.80
Cell Transformation	modulates	process	0.80
Tumor Progression	associated_with	process	0.80
CMA	associated_with	biological_process	0.80
Nf-Κb	regulates	pathway	0.80
protein_folding_pathway	participates_in	pathway	0.80
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Amyotrophic Lateral Sclerosis	activates	disease	0.75
Cancer	regulates	disease	0.75
oxidative stress response	participates_in	pathway	0.75
unfolded protein response	participates_in	pathway	0.75
Lung Cancer	biomarker_for	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Cancer	associated_with	disease	0.72
Apoptosis	regulates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Apoptosis	activates	pathway	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.70
poly-GA aggregates	activates	process	0.70
Spinal Muscular Atrophy	inhibits	disease	0.65
TDP-43	activates	gene	0.65
neurotrophin signaling	participates_in	pathway	0.65
Als	biomarker_for	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65

Incoming (450)

Source	Relation	Type	Str
AIMP2-DX2	interacts_with	protein	0.95
HSP40	activates	gene	0.85
Copper	upregulates	compound	0.85
BHB	upregulates	compound	0.80
NF-ΚB	regulates	gene	0.80
HSPA1A	encodes	gene	0.80
DNAJB1	activates	gene	0.75
PI3K	regulates	gene	0.70
CANCER	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
HIF	regulates	gene	0.70
UBQLN2	interacts_with	gene	0.70
TIA1	inhibits	gene	0.70
DNAJA1	activates	gene	0.65
APOE4	activates	gene	0.65
APOE4	regulates	gene	0.65
GDNF	protects_against	gene	0.65
HSP40	interacts_with	gene	0.65
HSP40	associated_with	gene	0.65
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
GRB2	phosphorylates	entity	0.60
HMGB1	phosphorylates	entity	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
CANCER	therapeutic_target	entity	0.60
CANCER	phosphorylates	entity	0.60
AMPK	activates	entity	0.60
CANCER	activates	entity	0.60
CANCER	associated_with	entity	0.60
CANCER	inhibits	entity	0.60
HSPA1A	expressed_in	gene	0.60
HSPA1A	associated_with	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.420	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (7)

Scientific analyses that reference this entity

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025
Extracellular chaperone networks and the export of J-domain proteins. [PMID:36581212]	Braun JEA	The Journal of biological chem	2023
DNAJB6 mutants display toxic gain of function through unregulated interaction wi [PMID:37923706]	Abayev-Avraham M, Salzberg Y, Gliksberg	Nature communications	2023
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuc [PMID:36302971]	Kuiper EFE, Gallardo P, Bergsma T, Mari	Nature cell biology	2022
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An Inte [PMID:34602496]	Megarbane A, Bizzari S, Deepthi A, Sabba	Journal of neuromuscular disea	2022
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkin [PMID:34390836]	["Arkan S", "Ljungberg M", "Kirik D", "H	Neurobiology of disease	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021
Panorama of the distal myopathies. [PMID:33458580]	Savarese M, Sarparanta J, Vihola A, Jons	Acta myologica : myopathies an	2020
Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395]	Wiltshire T, Ducy M, Foo TK, Hu C, Lee K	Genetics in medicine : officia	2020
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. [PMID:32268123]	["Thiruvalluvan A", "de Mattos E", "Brun	Molecular cell	2020
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment [PMID:30737131]	Merlini M, Rafalski VA, Rios Coronado PE	Neuron	2019
Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 [PMID:30564623]	Nallamilli BRR, Chakravorty S, Kesari A,	Annals of clinical and transla	2018
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. [PMID:27276715]	Meng E, Shevde LA, Samant RS	Oncotarget	2016

HSP70

Understanding Entity Pages

Summary

Wiki Pages (21)

HSP70 Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Alpha-Synuclein Pathology

Neuroresilience Mechanisms and Evidence

Pathway Diagram

Outgoing (699)

Incoming (450)

Targeting Hypotheses (1)

Mentioning Analyses (7)

Do chaperones selectively recognize pathological vs physiological protein confor

Epigenetic clocks and biological aging in neurodegeneration

Digital biomarkers and AI-driven early detection of neurodegeneration

APOE4 structural biology and therapeutic targeting strategies

TDP-43 phase separation therapeutics for ALS-FTD

Protein aggregation cross-seeding across neurodegenerative diseases

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (16)

HSP70

Understanding Entity Pages

Summary

Wiki Pages (21)

HSP70 Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Alpha-Synuclein Pathology

Neuroresilience Mechanisms and Evidence

Therapeutics

CBS/PSP Treatment Rankings

Multiple System Atrophy

nct07165106

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Niemann-Pick Disease Type C (NPC)

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Neuronal Ceroid Lipofuscinosis (NCL)

MACF1 — Microtubule-actin crosslinking factor 1

KARS1

RPL30 — Ribosomal Protein L30 in Neurodegeneration

Protein Aggregation Comparison in Neurodegeneration

TYNDASE — Tyndall

Synuclein Pathway in Parkinson's Disease

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

Pathway Diagram

Outgoing (699)

Incoming (450)

Targeting Hypotheses (1)

Mentioning Analyses (7)

Do chaperones selectively recognize pathological vs physiological protein confor

Epigenetic clocks and biological aging in neurodegeneration

Digital biomarkers and AI-driven early detection of neurodegeneration

APOE4 structural biology and therapeutic targeting strategies

TDP-43 phase separation therapeutics for ALS-FTD

Protein aggregation cross-seeding across neurodegenerative diseases

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (16)