protein

ARSAPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARSAPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Arylsulfatase A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	ARSAPROTEIN
Full Name	Arylsulfatase A
Protein Family	Arylsulfatase family
Protein Type	Hydrolase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	54 kDa (511 amino acids)
Amino Acids	511 aa
UniProt ID	P15289
GeneCards	ARSAPROTEIN
Human Protein Atlas	ARSAPROTEIN
Formylglycine (FGly) cofactor	Generated by the formylglycine-generating enzyme (FGE) at a conserved cysteine motif (C/S-X-P-X-R)
Active site	FGly coordinates sulfate ester hydrolysis
Homodimer formation	Two ARSA subunits associate for optimal activity
Glycosylation	N-linked glycans target the enzyme to lysosomes
Associated Diseases	neurodegeneration
Interactions	AGING, AUTOPHAGY, CCL2, CCL3, CTSD, CXCL12
KG Connections	27 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ARSAPROTEIN — AlphaFold P15289 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Arylsulfatase A Protein

protein · 693 words

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Pathway Diagram

graph TD
    ARSAPROTEIN["ARSAPROTEIN"]
    neurodegeneration["neurodegeneration"]
    ARSAPROTEIN -->|"implicated_in"| neurodegeneration
    style ARSAPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARSAPROTEIN in their description or question text

No additional research found