gene

CCL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CCL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 131 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	CCL3
Aliases	MIP-1α, LD78β
Chromosome	17q12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various cell types including: - Activated macrophages and monocytes - T cells and B cells - Neurons and glial cells (in CNS) - En
Molecular Weight	10 kDa
Amino Acids	99 aa
Pathways	Akt, Amyloid, Autophagy, Chaperone, Exocytosis
UniProt ID	P10147
Ensembl ID	ENSG00000108175
OMIM	182283
GeneCards	CCL3
Human Protein Atlas	CCL3
Gene Name	Chemokine C-C Motif Ligand 3
Also Known As	MIP-1α, LD78β
Associated Diseases	Als, Alzheimer, Cancer, Dementia, Inflammation, Ms
Known Drugs/Compounds	GW201
Interactions	C1Q, CCR5, AKT, PI3K, CCL5, TNF
KG Connections	303 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CCL3 — AlphaFold P10147 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CCL3["CCL3"]
    CCL3 -->|"activates"| CCR5["CCR5"]
    CCL3 -->|"upregulates"| IL1B["IL1B"]
    CCL3 -->|"upregulates"| TREM2["TREM2"]
    CCL3 -->|"activates"| Migraine["Migraine"]
    CCL3 -->|"activates"| Ms["Ms"]
    CCL3 -->|"activates"| Inflammation["Inflammation"]
    CCL3 -->|"activates"| Aging["Aging"]
    CCL3 -->|"activates"| Huntington["Huntington"]
    CCL3 -->|"activates"| Tauopathy["Tauopathy"]
    CCL3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PANX1["PANX1"] -->|"regulates"| CCL3
    S100B["S100B"] -->|"regulates"| CCL3
    RELB["RELB"] -->|"regulates"| CCL3
    P2RY1["P2RY1"] -->|"regulates"| CCL3
    CASP3["CASP3"] -->|"regulates"| CCL3
    SOCS3["SOCS3"] -->|"regulates"| CCL3
    TRPA1["TRPA1"] -->|"regulates"| CCL3
    GENES["GENES"] -->|"regulates"| CCL3
    CXCL2["CXCL2"] -->|"regulates"| CCL3
    SNAP25["SNAP25"] -->|"regulates"| CCL3

Outgoing (215)

Target	Relation	Type	Str
CCR5	activates	gene	0.90
IL1B	upregulates	gene	0.80
inflammatory response	promotes	process	0.75
Inflammation	associated_with	disease	0.75
TREM2	upregulates	gene	0.70
TNF-Α	activates	gene	0.70
Macrophage	associated_with	cell_type	0.70
Migraine	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Huntington	activates	disease	0.65
Tauopathy	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Depression	biomarker_for	disease	0.65
Autoimmune	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Prostate Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Senescence	activates	disease	0.65
Melanoma	inhibits	disease	0.65
Hepatitis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
C1Q	activates	gene	0.60
GFAP	associated_with	gene	0.60
AKT	activates	gene	0.60

Incoming (88)

Source	Relation	Type	Str
GW201	modulates	compound	0.85
GW201	downregulates	compound	0.80
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
VEGF	associated_with	gene	0.60
TNF	associated_with	gene	0.60
OSMR	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CCL5	activates	gene	0.60
CCL4	activates	gene	0.60
NOS2	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
C1Q	activates	gene	0.60
PI3K	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
STAT3	associated_with	gene	0.60
ERK1	activates	gene	0.60
P38	activates	gene	0.60
CGAS	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
CCR1	inhibits	gene	0.60
CXCR3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
CX3CR1	associated_with	gene	0.60
TLR2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CCL3

Understanding Entity Pages

Summary

Wiki Pages (21)

CCL3 Gene

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Neuroinflammation in Parkinson's Disease

TYROBP/DAP12 Microglia Signaling Pathway in Alzheimer's Disease

peripheral-immune-infiltration

S100 Protein Signaling Pathway in Neurodegeneration

Chemokine Signaling Pathway in Neurodegeneration

Neuroinflammation in [Parkinson's Disease](/diseases/parkinsons-disease)

CCR1

Chemokine Receptor Modulation for Parkinson's Disease

CXCL2 Protein

TREM2 Inflammatory Cytokine Regulation

Neuroimmune Interface Pathway

substantia-nigra-degeneration-parkinsons

IL1B — Interleukin-1 Beta

CBS Single-Cell Transcriptomics Mechanisms

CCR5 Protein

amyloid-responsive-microglia