ATP1A2

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ATP1A2 encodes the alpha-2 subunit of Na+/K+ ATPase, critical for astrocyte function, neuronal excitability, and implicated in migraine, epilepsy, ALS, and neurodegenerative diseases.

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flowchart TD
    N0["ATP1A2"]
    N1["Cancer"]
    N0 -->|"biomarker for"| N1
    N2["NTRK2"]
    N0 -->|"associated with"| N2
    N3["CANCER"]
    N0 -->|"biomarker for"| N3
    N4["SCN4B"]
    N0 -->|"associated with"| N4
    N5["CLDN4"]
    N0 -->|"associated with"| N5
    N6["App"]
    N0 -->|"biomarker for"| N6
    N4 -->|"associated with"| N0
    N7["SLC17A7"]
    N7 -->|"associated with"| N0
    N2 -->|"associated with"| N0
    N5 -->|"associated with"| N0
    N8["GENES"]
    N8 -->|"associated with"| N0
    N9["AND"]
    N9 -->|"associated with"| N0
    N10["HUB GENES"]
    N10 -->|"biomarker for"| N0
    N0 -->|"interacts with"| N7

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 protein
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene