concept

HUB GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUB GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HUB GENES
Key Genes/Proteins	ACO2, ADCY2, AGING, AIF1, AKT, AKT1
Related Diseases	Aging, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid

Pathway Diagram

graph TD
    HUB_GENES["HUB GENES"]
    style HUB_GENES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HUB_GENES -.->|"biomarker for"| Neutrophilic_Inflammation["Neutrophilic Inflammation"]
    HUB_GENES -->|"risk_factor_for"| COPD["COPD"]
    HUB_GENES -->|"involved_in"| Early_Diagnosis_Of_Septic_Card(Early Diagnosis Of Septic Cardiomyopathy)
    HUB_GENES -->|"expressed in"| Alzheimer["Alzheimer"]
    HUB_GENES -->|"expressed in"| Parkinson["Parkinson"]
    HUB_GENES -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    HUB_GENES -->|"activates"| Carcinoma["Carcinoma"]
    HUB_GENES -->|"activates"| Tumor["Tumor"]
    HUB_GENES -->|"activates"| ALS["ALS"]
    HUB_GENES -->|"activates"| Aging["Aging"]
    TP53([TP53]) -->|"regulates"| HUB_GENES
    GENES([GENES]) -->|"regulates"| HUB_GENES
    PARKINSON([PARKINSON]) -->|"expressed in"| HUB_GENES
    ALZHEIMER([ALZHEIMER]) -->|"expressed in"| HUB_GENES
    HSPA1A([HSPA1A]) -->|"regulates"| HUB_GENES
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"expressed in"| HUB_GENES
    RNA([RNA]) -->|"expressed in"| HUB_GENES
    CEBPA([CEBPA]) -->|"regulates"| HUB_GENES
    AND([AND]) -->|"regulates"| HUB_GENES
    HSPB1([HSPB1]) -->|"regulates"| HUB_GENES

Outgoing (232)

Target	Relation	Type	Str
Neutrophilic Inflammation	biomarker_for	process	0.92
COPD	risk_factor_for	disease	0.85
Early Diagnosis Of Septic Cardiomyopathy	involved_in	phenotype	0.80
Alzheimer'S Disease	therapeutic_target	disease	0.80
Dementia	expressed_in	disease	0.65
Migraine	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
ALS	regulates	disease	0.65
Diabetes	expressed_in	disease	0.65
Stroke	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Lewy Body	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
ALS	expressed_in	disease	0.65
Aging	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
APOPTOSIS	associated_with	gene	0.60
Necroptosis	associated_with	pathway	0.60

Incoming (173)

Source	Relation	Type	Str
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SLC17A7	biomarker_for	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
ACO2	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
CDK5R2	associated_with	gene	0.60
CLDN4	associated_with	gene	0.60
GJA1	interacts_with	gene	0.60
LPL	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
CALM1	interacts_with	gene	0.60
TXN	interacts_with	gene	0.60
GJA1	associated_with	gene	0.60
CCL2	associated_with	gene	0.60
CD4	associated_with	gene	0.60
FOS	associated_with	gene	0.60
CD44	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
RUNX2	associated_with	gene	0.60
NF-ΚB	regulates	gene	0.60
TGFBI	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
CD163	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
DEMENTIA	regulates	gene	0.60
NLRP3	expressed_in	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AKT1	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
RNA	regulates	gene	0.60
SNAP25	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
RHEB	regulates	gene	0.60
AXIN1	regulates	gene	0.60
SOCS3	regulates	gene	0.60
STAT3	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUB GENES in their description or question text

No additional research found