concept

HUB GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUB GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

416Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HUB GENES
Related Diseases	COPD, Early Diagnosis Of Septic Cardiomyopathy, Alzheimer'S Disease, Atherosclerosis, Stroke

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HUB_GENES["HUB GENES"]
    style HUB_GENES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HUB_GENES -.->|"biomarker for"| Neutrophilic_Inflammation["Neutrophilic Inflammation"]
    HUB_GENES -->|"risk_factor_for"| COPD["COPD"]
    HUB_GENES -->|"involved_in"| Early_Diagnosis_Of_Septic_Card(Early Diagnosis Of Septic Cardiomyopathy)
    HUB_GENES -->|"expressed in"| Alzheimer["Alzheimer"]
    HUB_GENES -->|"expressed in"| Parkinson["Parkinson"]
    HUB_GENES -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    HUB_GENES -->|"activates"| Carcinoma["Carcinoma"]
    HUB_GENES -->|"activates"| Tumor["Tumor"]
    HUB_GENES -->|"activates"| ALS["ALS"]
    HUB_GENES -->|"activates"| Aging["Aging"]
    TP53([TP53]) -->|"regulates"| HUB_GENES
    GENES([GENES]) -->|"regulates"| HUB_GENES
    PARKINSON([PARKINSON]) -->|"expressed in"| HUB_GENES
    ALZHEIMER([ALZHEIMER]) -->|"expressed in"| HUB_GENES
    HSPA1A([HSPA1A]) -->|"regulates"| HUB_GENES
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"expressed in"| HUB_GENES
    RNA([RNA]) -->|"expressed in"| HUB_GENES
    CEBPA([CEBPA]) -->|"regulates"| HUB_GENES
    AND([AND]) -->|"regulates"| HUB_GENES
    HSPB1([HSPB1]) -->|"regulates"| HUB_GENES

Outgoing (236)

Target	Relation	Type	Str
Neutrophilic Inflammation	biomarker_for	process	0.92
COPD	risk_factor_for	disease	0.85
Early Diagnosis Of Septic Cardiomyopathy	involved_in	phenotype	0.80
Alzheimer'S Disease	therapeutic_target	disease	0.80
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Aging	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Diabetes	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Epilepsy	associated_with	disease	0.65
Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Migraine	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Lewy Body	expressed_in	disease	0.65
STROKE	associated_with	gene	0.60
SPI1	regulates	gene	0.60

Incoming (180)

Source	Relation	Type	Str
C1Q	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GBM	associated_with	gene	0.60
LDL	associated_with	gene	0.60
C1QC	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
APOE	associated_with	gene	0.60
C1Q-RELATED HUB GENES	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
TP53	regulates	gene	0.60
GENES	regulates	gene	0.60
PARKINSON	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
HSPA1A	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
CEBPA	regulates	gene	0.60
AND	regulates	gene	0.60
HSPB1	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
TNF	regulates	gene	0.60
NF-ΚB	associated_with	gene	0.60
MMP9	regulates	gene	0.60
IL-17	associated_with	gene	0.60
TLR2	regulates	gene	0.60
JUN	regulates	gene	0.60
CXCL8	regulates	gene	0.60
IL1B	regulates	gene	0.60
MGA	regulates	gene	0.60
BRD4	activates	gene	0.60
IGF2BP2	activates	gene	0.60
ONCOGENES	activates	gene	0.60
GENES	expressed_in	gene	0.60
TIMMDC1	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
LYRM7	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
CD14	expressed_in	gene	0.60
BCS1L	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GENES	activates	gene	0.60
TNF	associated_with	gene	0.60
AND	activates	gene	0.60
NAMPT	associated_with	gene	0.60
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SLC17A7	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HUB GENES

Understanding Entity Pages

Wiki Pages (11)

AI and Machine Learning in Neurodegeneration

Brain Network Connectivity in PSP

CCR1

hpgv-parkinsons

TGFBI

SLC6A1

ELAVL2 Gene

Computational Notebooks

Normal Aging to Alzheimer's Disease Transition Trigger — Identifying the Critical Switch Point

Nucleus of the Solitary Tract (NTS) Neurons