gene

NTRK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

Neurotrophic Receptor Tyrosine Kinase 2, BDNF receptor TrkB

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🧬 Gene Info
Gene SymbolNTRK2
Full NameNeurotrophic Receptor Tyrosine Kinase 2
Chromosome9q22.1
Protein TypeReceptor
Functionencodes the BDNF (brain-derived neurotrophic factor) receptor, also known as TrkB
PathwaysPI3K, MAPK, mTOR
UniProt IDQ16620
NCBI Gene ID4915
Ensembl IDENSG00000148018
OMIM600456
GeneCardsNTRK2
Human Protein AtlasNTRK2
ApproachStatus
BDNF mimeticsResearch
TrkB agonistsClinical trials
Associated DiseasesAlzheimer, Alzheimer'S Disease, disease
InteractionsBDNF, TRKB, PAK1, WNT7A, LZTS1, DCC
KG Connections254 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NTRK2 — AlphaFold Q16620 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NTRK2 Gene

gene · 2414 words

NTF4 Protein

protein · 5111 words

Growth Factor Therapeutics: Investment Landscape Analysis

investment · 4064 words

Claustrum Neurons

cell · 3613 words

Allen Human Brain Atlas

dataset · 3555 words

BDNF/Neurotrophin Signaling in Neurodegeneration

mechanism · 3338 words

Pathway Diagram

graph TD
    NTRK2["<b>NTRK2</b>"]
    FGF7["FGF7"]
    NTRK2 -->|"regulates"| FGF7
    Ms{"Ms"}
    NTRK2 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    NTRK2 -->|"inhibits"| Carcinoma
    NTRK2 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    NTRK2 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    NTRK2 -->|"inhibits"| Tumor
    NTRK2 -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    NTRK2 -->|"interacts with"| Inflammation
    Schizophrenia{"Schizophrenia"}
    NTRK2 -->|"interacts with"| Schizophrenia
    BDNF["BDNF"]
    NTRK2 -->|"activates"| BDNF
    TRKB["TRKB"]
    NTRK2 -->|"activates"| TRKB
    PAK1["PAK1"]
    NTRK2 -->|"inhibits"| PAK1
    BDNF -->|"interacts with"| NTRK2
    BDNF -->|"activates"| NTRK2
    TRKB -->|"activates"| NTRK2
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| NTRK2
    TLR4["TLR4"]
    TLR4 -->|"associated with"| NTRK2
    CANCER["CANCER"]
    CANCER -->|"inhibits"| NTRK2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| NTRK2
    TNC["TNC"]
    TNC -->|"associated with"| NTRK2
    AND["AND"]
    AND -->|"activates"| NTRK2
    style NTRK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (159)

TargetRelationTypeStr
Synaptic Clusteringmediatesprocess0.95
Antidepressant Responseinvolved_inphenotype0.88
Adenosine A2A Receptorinteracts_withreceptor0.82
FGF7regulatesprotein0.70
tauco_discussedconcept0.65

Incoming (95)

SourceRelationTypeStr
BDNFbinds_toprotein0.95
BDNFupregulatesgene0.88
BDNFinteracts_withprotein0.70
CDK5co_discussedgene0.65
LRRK2co_discussedgene0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found