protein

ATXN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	ATXN1PROTEIN
Function	is a 815 amino acid nuclear protein that plays critical roles in transcriptional regulation and RNA processing.
Primary Expression	neural tissues[@matilla1998]:
Subcellular Localization	signal (NLS)**: Directs nuclear import 4
GeneCards	ATXN1PROTEIN
Human Protein Atlas	ATXN1PROTEIN
Co-repressor activity	Interacts with transcription factors including RORα
CtBP interaction	Partners with C-terminal binding protein (CtBP)
Nuclear import	Associates with importin proteins
Gene expression	Modulates neuronal gene expression programs
RNA binding	Associates with RNA processing complexes
Splicing factors	Interacts with splicing machinery
mRNA export	May influence mRNA trafficking
Normal range	6-36 CAG repeats
Pathogenic range	41-83+ CAG repeats
Associated Diseases	Ataxia, Huntington's disease, neurodegeneration
Interactions	BDNF, CIC, NEURON, PKA
KG Connections	28 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ataxin-1 Protein

protein · 1193 words

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Pathway Diagram

graph TD
    ATXN1PROTEIN["ATXN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ATXN1PROTEIN -->|"implicated_in"| neurodegeneration
    style ATXN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ATXN1PROTEIN in their description or question text

No additional research found