entity

AUTOPHAGY INITIATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY INITIATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

1Hypotheses

4Analyses

1Outgoing

17Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (1)

Target	Relation	Type	Str
lysosomal degradation	associated_with	process	0.70

Incoming (17)

Source	Relation	Type	Str
ULK1	regulates	protein	0.95
VPS34-BECLIN-1 COMPLEX	regulates	protein	0.95
MTOR	inhibits	gene	0.90
mTOR	activates	protein	0.90
MTOR	inhibits	gene	0.90
ULK1 Complex	involved_in	protein	0.90
ULK1	involved_in	protein	0.90
ULK1 phosphorylation at Ser757	inhibits	process	0.90
BECN1	regulates	protein	0.90
RB1CC1	involved_in	protein	0.87
MTOR	regulates	protein	0.85
ULK1	upstream_of	gene	0.85
Selective Autophagy	mediates	process	0.80
ULK1	activates	gene	0.70
NBR1	activates	protein	0.70
PI3P	regulates	lipid	0.70
ULK1	initiates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def

Mentioning Analyses (4)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 19 hypotheses Top: 0.591

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

neurodegeneration | 2026-04-08 | 3 hypotheses Top: 0.470

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

The finding that trehalase-resistant analogs and other disaccharides mimic treha

closed · Rounds: 4 · Score: 0.60 · 2026-04-21

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

closed · Rounds: 4 · Score: 0.94 · 2026-04-10

Related Research

Hypotheses and analyses mentioning AUTOPHAGY INITIATION in their description or question text

No additional research found