gene

NBR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NBR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1436Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NBR1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 674 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NBR1
Full Name	Neighbor of BRCA1 Gene 1
Chromosome	17q21.31
Protein Type	Receptor
Function	NBR1 is a selective autophagy receptor
Primary Expression	all brain cell types:
Pathways	Akt, Autophagy, Chaperone, Innate Immunity, Lysosomal Degradation
UniProt ID	Q14596
NCBI Gene ID	10327
Ensembl ID	ENSG00000132716
OMIM	605085
GeneCards	NBR1
Human Protein Atlas	NBR1
Cell Type	Expression Level
[Neurons](/entities/neurons)	High
Associated Diseases	AD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compounds	dimethyl fumarate, rapamycin
Interactions	G3BP1, TOLLIP, SQSTM1, NDP52, TAX1BP1, FUS
KG Connections	1436 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NBR1 — AlphaFold Q14596 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NBR1["NBR1"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NBR1["NBR1"] -->|"interacts"| Dementia["Dementia"]
    NBR1["NBR1"] -->|"interacts"| Als["Als"]
    NBR1["NBR1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    NBR1["NBR1"] -->|"interacts"| Alzheimer["Alzheimer"]
    NBR1["NBR1"] -->|"interacts"| Parkinson["Parkinson"]
    ACTB["ACTB"] -->|"interacts"| NBR1["NBR1"]
    OPTN["OPTN"] -->|"interacts"| NBR1["NBR1"]
    ULK1["ULK1"] -->|"interacts"| NBR1["NBR1"]
    SMCR8["SMCR8"] -->|"interacts"| NBR1["NBR1"]
    style NBR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (783)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Aggrephagy	involved_in	process	0.95
Lipophagy	involved_in	process	0.95
Aggrephagy	biomarker_for	process	0.95
Als	regulates	disease	0.95
STAT2	inhibits	protein	0.90
STING	inhibits	protein	0.90
TRIM32	inhibits	protein	0.90
interferon	inhibits	protein	0.90
Myofibrillar Myopathy	biomarker_for	disease	0.90
Disease Severity	correlates_with	phenotype	0.90
Myofibrillar Myopathies	biomarker_for	disease	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
Selective Autophagy	involved_in	process	0.85
Lipid Droplet	binds	organelle	0.85
hepatocellular carcinoma	contributes_to	disease	0.80
NDP52	regulates	gene	0.80
SQSTM1	regulates	gene	0.80
RB1	activates	gene	0.80
RB1	regulates	gene	0.80
RB1CC1	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
NLR	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
OPTN	associated_with	gene	0.80
UBIQUITIN	activates	gene	0.80
Autophagy	associated_with	pathway	0.80
Als	interacts_with	disease	0.75
Parkinson	associated_with	disease	0.75
Als	activates	disease	0.75
Cancer	regulates	disease	0.75
Neurodegeneration	regulates	disease	0.75
MTOR	associated_with	gene	0.70
selective autophagy	regulates	process	0.70
Tau protein	interacts_with	protein	0.70
Tau protein	regulates	protein	0.70
autophagy	activates	process	0.70
MAPT	interacts_with	protein	0.70
MAPT	regulates	protein	0.70
neurological diseases	associated_with	disease	0.70
amyloid-β	regulates	protein	0.70
ubiquitin	interacts_with	protein	0.70
autophagy initiation	activates	process	0.70
lipid droplets	recognizes	process	0.70
lipophagy	regulates	process	0.70
lysosomal degradation	activates	process	0.70
myofibrillar myopathy	biomarker_for	disease	0.70
aggrephagy	regulates	process	0.70
muscle	expressed_in	cell_type	0.70

Incoming (653)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
p62	interacts_with	protein	0.80
PSMB1	interacts_with	gene	0.80
BECN1	regulates	gene	0.80
LC3	regulates	gene	0.80
CALCOCO2	regulates	gene	0.80
FIP200	regulates	gene	0.80
TFEB	associated_with	gene	0.80
STING	activates	gene	0.80
LC3B	activates	gene	0.80
OPTN	associated_with	gene	0.70
CALCOCO2	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
RB1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
P62	interacts_with	gene	0.70
NDP52	interacts_with	gene	0.70
PIK3C3	associated_with	gene	0.70
NDP52	associated_with	gene	0.70
P62	associated_with	gene	0.70
BAG3	interacts_with	protein	0.70
BAG3	activates	protein	0.70
BAG3	regulates	protein	0.70
Mirc1/Mir17-92a	inhibits	gene	0.70
P62	activates	gene	0.70
NDP52	activates	gene	0.70
OPTN	activates	gene	0.70
CGAS	regulates	gene	0.70
G3BP1	regulates	gene	0.70
JNK	regulates	gene	0.70
MTOR	regulates	gene	0.70
DDIT3	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
ERN1	regulates	gene	0.70
ATG	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
PARKINSON	associated_with	gene	0.70
NF-ΚB	regulates	gene	0.70
MAP1LC3	activates	gene	0.70
ALS	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
ATG	activates	gene	0.70
DNA	activates	gene	0.70
AMPK	regulates	gene	0.70
ATG	regulates	gene	0.70
DNA	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NBR1

Understanding Entity Pages

Summary

Wiki Pages (21)

NBR1 Gene

Autophagy Mechanisms

proteasome-ubiquitin-system-dysfunction-parkinsons

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

ZFYVE26 Gene

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Mitophagy Pathway in Neurodegeneration

Oxidative Stress in Neurodegeneration

autophagy-lysosome-dysfunction

TRIM2 Gene (Tripartite Motif Containing 2)

MAPT (Microtubule-Associated Protein Tau) Gene

MAP1LC3A Gene

PSP Ferroptosis and Iron-Dependent Cell Death

Autophagy-Lysosomal Pathway

autophagy

Autophagy-Impaired Neurons

Alpha-Synuclein Clearance Mechanisms

Protein Aggregation in Neurodegeneration