disease

alpha-synucleinopathies

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about alpha-synucleinopathies: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
0Hypotheses
1Analyses
7Outgoing
1Incoming

No summary available yet. View on Wiki →

Disease Info
Associated GenesAPOE
KG Connections8 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (20)

Knowledge base pages for this entity

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Atypical Parkinsonism

disease · 6876 words

Alpha-Synuclein Pathology

mechanism · 6288 words

PD Combination Therapy Matrix

mechanism · 5949 words

Multiple System Atrophy

page · 5281 words

Pathway Diagram

flowchart TD
    alpha_synucleinopathies["alpha-synucleinopathies"]
    Alpha_Synuclein(["Alpha-Synuclein"])
    SNCA(["SNCA"])
    PARKINSON(["PARKINSON"])
    Parkinson_s_Disease["Parkinson's Disease"]
    disease["disease"]
    PARKINSON_S("PARKINSON'S")
    SYNUCLEIN("SYNUCLEIN")

    alpha_synucleinopathies -->|"associated with"| Alpha_Synuclein
    alpha_synucleinopathies -->|"associated with"| SNCA
    alpha_synucleinopathies -->|"associated with"| PARKINSON
    alpha_synucleinopathies -->|"associated with"| Parkinson_s_Disease
    alpha_synucleinopathies -->|"associated with"| disease
    alpha_synucleinopathies -->|"associated with"| PARKINSON_S
    alpha_synucleinopathies -->|"associated with"| SYNUCLEIN

    style alpha_synucleinopathies fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (8)

TargetRelationTypeStr
SNCAassociated_withgene0.50
Alpha-Synucleinassociated_withprotein0.50
PARKINSONassociated_withgene0.50
Parkinson's Diseaseassociated_withdisease0.50
diseaseassociated_withdisease0.50

Incoming (4)

SourceRelationTypeStr
APOEassociated_withgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found