protein

Alpha-Synuclein

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Alpha-Synuclein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1819Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Alpha-Synuclein is a protein involved in neurodegeneration research. Key relationships include: regulates, causes, activates. Associated with ALS, Aging, Alzheimer. Connected to 111 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ALPHA-SYNUCLEIN
Chromosome	4q21.31
Protein Family	Synuclein family
Subcellular Localization	Presynaptic terminals, nucleus
Molecular Weight	14 kDa (140 aa)
Pathways	amyloid plaques, mTORC1, oxidative stress
UniProt ID	P37840
GeneCards	ALPHA-SYNUCLEIN
Human Protein Atlas	ALPHA-SYNUCLEIN
Associated Diseases	ALZHEIMER'S DISEASE, Aging, Als, Alzheimer, Dementia, Huntington
Known Drugs/Compounds	UB-312, AFFITOPE PD01A, Prasinezumab, Cinpanemab
Interactions	BMAL1, Prion, Proteins, PARKINSON, ALZHEIMER, AMYLOID
KG Connections	584 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: Alpha-Synuclein — AlphaFold P37840 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Alpha_Synuclein["Alpha-Synuclein"] -->|"involved in"| Parkinson_s_Disease["Parkinson's Disease"]
    Alpha_Synuclein["Alpha-Synuclein"] -->|"causes"| Synucleinopathies["Synucleinopathies"]
    Alpha_Synuclein["Alpha-Synuclein"] -->|"causes"| Lewy_Body_Formation["Lewy Body Formation"]
    Alpha_Synuclein["Alpha-Synuclein"] -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    Alpha_Synuclein["Alpha-Synuclein"] -->|"associated"| Parkinson_s_Disease_1["Parkinson's Disease"]
    Alpha_Synuclein["Alpha-Synuclein"] -->|"modulates"| Inflammation["Inflammation"]
    GCASE["GCASE"] -->|"causes"| Alpha_Synuclein["Alpha-Synuclein"]
    NEURON["NEURON"] -->|"causes"| Alpha_Synuclein["Alpha-Synuclein"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"causes"| Alpha_Synuclein["Alpha-Synuclein"]
    PARKINSON["PARKINSON"] -->|"causes"| Alpha_Synuclein["Alpha-Synuclein"]
    style Alpha_Synuclein fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1016)

Target	Relation	Type	Str
Parkinson's Disease	involved_in	disease	0.95
Synucleinopathies	causes	disease	0.95
Lewy Body Formation	involved_in	process	0.95
Lewy Bodies	involved_in	biomarker	0.95
Liquid-Liquid Phase Separation	involved_in	process	0.95
Mitochondrial Quality Control	modulates	pathway	0.95
Parkinson's Disease	contributes_to	disease	0.95
NLRP3	activates	protein	0.93
Dopaminergic Neurodegeneration	associated_with	process	0.93
MICROGLIA	activates	cell_type	0.92
Lewy Body Formation	causes	process	0.90
Neurodegeneration	contributes_to	process	0.90
Neurodegeneration	causes	process	0.90
Parkinson'S Disease	associated_with	disease	0.90
NEUROINFLAMMATION	promotes	process	0.90
STING	activates	protein	0.90
PARKINSON'S DISEASE	associated_with	disease	0.90
KV1.3	upregulates	gene	0.90
Parkinson'S Disease	involved_in	disease	0.90
Lewy Bodies	associated_with	biomarker	0.90
Dopaminergic Neuronal Loss	contributes_to	phenotype	0.90
Parkinson's Disease	associated_with	disease	0.85
Inflammation	modulates	process	0.85
Prion-Like Aggregation	mediates	mechanism	0.85
Parkinson's Disease	biomarker_for	disease	0.85
Neuroinflammation	associated_with	process	0.85
ASTROCYTES	activates	cell_type	0.85
Dna Damage	causes	mechanism	0.85
Microglia	activates	cell_type	0.85
Tau Pathology	promotes	mechanism	0.85
ROS/RNS	mediates	compound	0.80
Ferroptosis	associated_with	process	0.80
Alpha-Synucleinopathies	biomarker_for	disease	0.80
Mitochondrial Biogenesis	regulates	process	0.80
Mitochondrial Dynamics	regulates	process	0.80
Mitophagy	regulates	process	0.80
Mitochondrial Function	modulates	process	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.75
Aging	causes	disease	0.60
Parkinson	causes	disease	0.60
Senescence	causes	disease	0.60
Parkinson	contributes_to	disease	0.60
Neurodegeneration	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	regulates	disease	0.60
Stroke	regulates	disease	0.60
Neurodegeneration	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Als	associated_with	disease	0.60

Incoming (803)

Source	Relation	Type	Str
Autophagy	downregulates	process	0.95
UB-312	targets	drug	0.90
AFFITOPE PD01A	targets	drug	0.90
Prasinezumab	targets	drug	0.90
Cinpanemab	targets	drug	0.90
LAG3	binds	protein	0.90
DNAJB6	suppresses	protein	0.90
SDA-2026-04-01-gap-20260401-225155	investigates	analysis	0.90
TAU	interacts_with	protein	0.90
APLP1	associated_with	protein	0.85
Autophagy	mediates	process	0.85
LRRK2	interacts_with	protein	0.85
GCASE	causes	gene	0.60
NEURON	causes	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	causes	gene	0.60
PLIN2	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60
AGING	causes	gene	0.60
GBA	causes	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
LAMP1	contributes_to	gene	0.60
MICROGLIA	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
PROINFLAMMATORY CYTOKINES	contributes_to	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
CYTOKINES	contributes_to	gene	0.60
TMEM175	contributes_to	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
TFEB	contributes_to	gene	0.60
GBA	contributes_to	gene	0.60
6-OHDA	regulates	gene	0.60
FERROPORTIN	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DJ-1	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
BCL-2	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
STROKE	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.595	neurodegeneration	How does engineered C. butyricum cross t
Neuronal Subtype-Specific Alpha-Synuclein Expression Normali	0.382	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Meta-analysis of mRNA dysregulation associated with Parkinson's disease and othe [PMID:41183391]	Lin Aung T, Aung YW, Shi X	Biomed Phys Eng Express	2026	1
A human striatal-midbrain assembloid model of alpha-synuclein propagation. [PMID:40919647]	Tran HD, Shin MK, Yeo XY, Jung S, Junaid	Brain	2026	0
Neuronal titration of Snca via enhancer disruption mitigates disease onset in a [PMID:41496593]	Boyd RJ, Kho AR, McClymont SA, Loftus SK	Brain	2026	0
Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in [PMID:41508763]	Ueda J, Uemura N, Chang J, Hirato T, Ish	Mov Disord	2026	0
Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 p [PMID:41574889]	Fraser KB, Mirelman A, Mabrouk OS, Omer	J Parkinsons Dis	2026	0
Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in [PMID:41635116]	Wang Y, Lipton SA	J Neurochem	2026	0
SNCA triplication disrupts proteostasis and extracellular architecture prior to [PMID:41698927]	Statoulla E, Zafeiri M, Chalkiadaki K, V	NPJ Parkinsons Dis	2026	0
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's dise [PMID:41730496]	Panda SP, Saraswat N, Singh V	Neuroscience	2026	0
Degradation of alpha-synuclein/SNCA mRNA by RNautophagy. [PMID:41747943]	Kabuta C, Hakuno F, Kataoka N, Takahashi	Neurochem Int	2026	0
An update on the monogenic causes of Parkinson's disease: Impact on patient stra [PMID:41759745]	Asmi S, Krishnan A, Alexander SM, Mohame	Ageing Res Rev	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621]	["Singh R", "Maity P", "Jaiswal C"]	Neurochemistry international	2026	0

Alpha-Synuclein

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene