Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNUCLEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SYNUCLEIN |
| Category | antibody-design, zero-shot, synbio, nasdaq-absi |
| Key Genes/Proteins | AMYLOID, TAU, UBIQUITIN, P62, IL-6, SOD1 |
| Related Diseases | ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, ALS |
| Linked Hypotheses | 7 hypotheses |
Knowledge base pages for this entity
graph TD
SYNUCLEIN["SYNUCLEIN"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"causes"| SYNUCLEIN
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| SYNUCLEIN
P62["P62"] -->|"activates"| SYNUCLEIN
SQSTM1["SQSTM1"] -->|"activates"| SYNUCLEIN
MICROGLIA["MICROGLIA"] -->|"inhibits"| SYNUCLEIN
ASTROCYTES["ASTROCYTES"] -->|"activates"| SYNUCLEIN
ALS["ALS"] -->|"activates"| SYNUCLEIN
AMPK["AMPK"] -->|"activates"| SYNUCLEIN| Target | Relation | Type | Str |
|---|---|---|---|
| Reactive Oxygen Species | activates | process | 0.50 |
| NUCLEUS | activates | concept | 0.50 |
| ENDOPLASMIC RETICULUM | activates | concept | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| AMYLOID-β | interacts_with | concept | 0.50 |
| α-SYNUCLEIN | interacts_with | concept | 0.50 |
| α-SYNUCLEIN | inhibits | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| DOPAMINE | associated_with | concept | 0.50 |
| DOPAMINE | causes | concept | 0.50 |
| α-SYNUCLEIN | causes | concept | 0.50 |
| DOPAMINE | activates | concept | 0.50 |
| α-SYNUCLEIN | activates | concept | 0.50 |
| DOPAMINE | inhibits | concept | 0.50 |
| DOPAMINE | regulates | concept | 0.50 |
| α-SYNUCLEIN | regulates | concept | 0.50 |
| DOPAMINERGIC NEURONS | interacts_with | concept | 0.50 |
| RAPAMYCIN | interacts_with | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | interacts_with | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| LEWY BODY | associated_with | concept | 0.50 |
| α-SYNUCLEIN | protects_against | concept | 0.50 |
| α-SYNUCLEIN | expressed_in | concept | 0.50 |
| DOPAMINERGIC NEURONS | regulates | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| Proteins | inhibits | protein | 0.50 |
| LEWY BODY | inhibits | concept | 0.50 |
| Gut Microbiota | associated_with | process | 0.50 |
| DOPAMINERGIC NEURONS | associated_with | concept | 0.50 |
| SELECTIVE AUTOPHAGY | protects_against | concept | 0.50 |
| DOPAMINERGIC NEURONS | causes | concept | 0.50 |
| LEWY BODY | expressed_in | concept | 0.50 |
| AMYLOID-β | associated_with | concept | 0.50 |
| Reactive Oxygen Species | causes | process | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| HCRT | regulates | concept | 0.50 |
| LEWY BODY | interacts_with | concept | 0.50 |
| Proteins | regulates | protein | 0.50 |
| DOPAMINERGIC NEURONS | inhibits | concept | 0.50 |
| NEUROFIBRILLARY TANGLES | associated_with | concept | 0.50 |
| Proteins | expressed_in | protein | 0.50 |
| NEUROFIBRILLARY TANGLES | expressed_in | concept | 0.50 |
| LEWY BODY | activates | concept | 0.50 |
| GLIOSIS | inhibits | concept | 0.50 |
| MICROGLIAL ACTIVATION | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| MICROGLIA | associated_with | cell_type | 1.00 |
| AMYLOID | associated_with | protein | 1.00 |
| ASTROCYTES | associated_with | cell_type | 1.00 |
| TAU | associated_with | protein | 1.00 |
| PARKINSON'S DISEASE | causes | disease | 0.98 |
| UBIQUITIN | associated_with | protein | 0.98 |
| P62 | associated_with | protein | 0.98 |
| IL-6 | associated_with | gene | 0.90 |
| PARKINSON'S DISEASE | activates | disease | 0.90 |
| ALS | associated_with | disease | 0.82 |
| SOD1 | associated_with | gene | 0.82 |
| NF-KB | associated_with | protein | 0.82 |
| PARKIN | associated_with | gene | 0.82 |
| LRRK2 | associated_with | gene | 0.82 |
| PINK1 | associated_with | gene | 0.82 |
| TARDBP | associated_with | gene | 0.82 |
| AMYLOID | interacts_with | protein | 0.74 |
| TAU | interacts_with | protein | 0.74 |
| MTOR | associated_with | gene | 0.74 |
| TNF | associated_with | gene | 0.74 |
| PARKINSON'S DISEASE | regulates | disease | 0.74 |
| AKT | associated_with | gene | 0.66 |
| PI3K | associated_with | gene | 0.66 |
| APOE | associated_with | gene | 0.66 |
| NRF2 | associated_with | gene | 0.66 |
| PARKIN | causes | gene | 0.66 |
| SQSTM1 | associated_with | gene | 0.66 |
| MICROGLIA | activates | cell_type | 0.64 |
| P62 | activates | protein | 0.56 |
| SQSTM1 | activates | gene | 0.56 |
| PARKINSON'S DISEASE | mediates | disease | 0.56 |
| MICROGLIA | inhibits | cell_type | 0.56 |
| ASTROCYTES | activates | cell_type | 0.56 |
| PARKINSON'S DISEASE | interacts_with | disease | 0.56 |
| TAU | phosphorylates | protein | 0.56 |
| MTOR | activates | gene | 0.56 |
| CASP3 | associated_with | gene | 0.56 |
| TAU | activates | protein | 0.56 |
| AMYLOID | activates | protein | 0.56 |
| LRRK2 | activates | gene | 0.56 |
| AMBRA1 | activates | protein | 0.50 |
| PERK | activates | gene | 0.50 |
| HIF1A | activates | gene | 0.50 |
| ABCD3 | activates | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
| MITOCHONDRIA | activates | cell_type | 0.50 |
| SNCA | activates | gene | 0.50 |
| STING1 | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| H7: Enteric Nervous System Alpha-Synuclein Propagation Block | 0.595 | neurodegeneration | How does engineered C. butyricum cross t |
| Ferroptosis Inhibition for α-Synuclein Neuroprotection | 0.548 | neurodegeneration | Gene expression changes in aging mouse b |
| Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro | 0.488 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut Barrier Permeability-α-Synuclein Axis Modulation | 0.487 | neurodegeneration | What are the mechanisms by which gut mic |
| Microbial Metabolite-Mediated α-Synuclein Disaggregation | 0.448 | neurodegeneration | What are the mechanisms by which gut mic |
| Neuronal Subtype-Specific Alpha-Synuclein Expression Normali | 0.382 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.537
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Meta-analysis of mRNA dysregulation associated with Parkinson's disease and othe [PMID:41183391] | Lin Aung T, Aung YW, Shi X | Biomed Phys Eng Express | 2026 | 1 |
| Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Jun [PMID:40647158] | ["Zheng X", "Cao Z", "Wang M", "Yuan R", | Nutrients | 2025 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] | Jiang H, Hu W, Yuan L | Tohoku J Exp Med | 2026 | 0 |
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| 4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] | Zhang S, Yue T, Jin P, Zhang X, Huo Q et | Free Radic Biol Med | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] | Hao W, Sun N, Xue R, Chang J, Pang X et | ACS Appl Mater Interfaces | 2026 | 0 |
| Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] | Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G | Adv Sci (Weinh) | 2026 | 0 |
| Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] | Zayed M, Tayara H, Jeong BH | Redox Biol | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |