Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AMYLOID DEPOSITION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AMYLOID DEPOSITION |
graph TD
AMYLOID_DEPOSITION[AMYLOID DEPOSITION]
AMYLOID_DEPOSITION -->|activates| neuroinflammation[neuroinflammation]
Alps_Index[Alps Index] -.biomarker for.-> AMYLOID_DEPOSITION
APOE__2[APOE ε2] -->|inhibits| AMYLOID_DEPOSITION
APOE2[APOE2] -->|reduces| AMYLOID_DEPOSITION
APOE[APOE] -->|downregulates| AMYLOID_DEPOSITION
BACE1[BACE1] -->|involved_in| AMYLOID_DEPOSITION
APP_PS1[APP/PS1] -->|causes| AMYLOID_DEPOSITION| Target | Relation | Type | Str |
|---|---|---|---|
| disease-associated microglia | causes | cell_type | 0.70 |
| PGE2/LTB4 production | activates | mechanism | 0.70 |
| neuroinflammation | associated_with | process | 0.70 |
| neuroinflammation | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Glymphatic System Dysfunction | associated_with | process | 0.95 |
| Alps Index | biomarker_for | biomarker | 0.92 |
| APOE ε2 | inhibits | protein | 0.90 |
| APOE ε2 | reduces | gene | 0.90 |
| APOE2 | reduces | gene | 0.90 |
| APOE | reduces | gene | 0.90 |
| APOE | downregulates | gene | 0.90 |
| APOE | risk_factor_for | gene | 0.90 |
| BACE1 | involved_in | gene | 0.89 |
| APP | associated_with | gene | 0.85 |
| APP/PS1 | causes | gene | 0.85 |
| APP | associated_with | gene | 0.80 |
| CD36 deficiency | causes | process | 0.70 |
| White Matter Pathology | associated_with | phenotype | 0.70 |
| ABCA1 | inhibits | gene | 0.70 |
| C3 deficiency | causes | phenotype | 0.70 |
| hub regions | associated_with | brain_region | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| AQP4 depolarization | precedes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.609
connectomics | 2026-04-16 | 13 hypotheses Top: 0.535
neuroinflammation | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-12 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.65 · 2026-04-16
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
Hypotheses and analyses mentioning AMYLOID DEPOSITION in their description or question text
No additional research found