Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AMYLOID-BETA CLEARANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AMYLOID-BETA CLEARANCE |
Knowledge base pages for this entity
graph TD
AMYLOID_BETA_CLEARANCE["AMYLOID-BETA CLEARANCE"]
Microglia["Microglia"] -->|"mediates"| AMYLOID_BETA_CLEARANCE
TREM2["TREM2"] -->|"involved_in"| AMYLOID_BETA_CLEARANCE
APOE["APOE"] -->|"involved_in"| AMYLOID_BETA_CLEARANCE
Astrocytic_Autophagy_Lysosome_["Astrocytic Autophagy-Lysosome Pathway"] -->|"mediates"| AMYLOID_BETA_CLEARANCE
Apolipoprotein_E["Apolipoprotein E"] -->|"regulates"| AMYLOID_BETA_CLEARANCE| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive Recovery | associated_with | phenotype | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Microglia | mediates | cell_type | 0.95 |
| LRP1 Upregulation | associated_with | process | 0.90 |
| DGAT2 Inhibition | associated_with | mechanism | 0.90 |
| TREM2 | involved_in | gene | 0.90 |
| APOE | involved_in | gene | 0.90 |
| APOE | promotes | gene | 0.90 |
| Astrocytic Autophagy-Lysosome Pathway | mediates | pathway | 0.90 |
| Apolipoprotein E | regulates | protein | 0.90 |
| TFEB | activates | gene | 0.90 |
| Microglia | involved_in | cell_type | 0.90 |
| microglia | involved_in | cell_type | 0.90 |
| Complement Signaling | contributes_to | pathway | 0.85 |
| Lecanemab | associated_with | drug | 0.85 |
| PICALM | regulates | gene | 0.85 |
| APOE | suppresses | gene | 0.85 |
| Mtorc1 | suppresses | protein | 0.85 |
| CD33 | regulates | gene | 0.85 |
| TREM2 | regulates | gene | 0.85 |
| Microglia | contributes_to | cell_type | 0.85 |
| microglia | mediates | cell_type | 0.85 |
| Perivascular Space Function | involved_in | process | 0.83 |
| TREM2 | modulates | protein | 0.80 |
| MICROGLIA | impairs | cell_type | 0.80 |
| SYK | associated_with | protein | 0.75 |
| CD33 | modulates | protein | 0.75 |
| LRP1 | therapeutic_target | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||