gene

PICALM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PICALM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

415Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Gene profile: PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein, key AD risk gene involved in clathrin-mediated endocytosis

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🧬 Gene Info

Gene Symbol	PICALM
Full Name	Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome	10q24.2
Function	is a gene located on chromosome 10q24.
Primary Expression	Brain, Blood cells, Heart, Lung
Molecular Weight	70 kDa
Amino Acids	652 aa
Exons	21
Pathways	Amyloid, Autophagy, Clathrin-mediated Endocytosis, Complement, Glucose Metabolism
UniProt ID	Q7Z417
NCBI Gene ID	81501
Ensembl ID	ENSG00000021762
OMIM	610004
GeneCards	PICALM
Human Protein Atlas	PICALM
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Cognitive Resilience
Interactions	LRP1, TAU, TREM2, MS4A4E, CLU, APOE
KG Connections	415 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PICALM — AlphaFold Q7Z417 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PICALM["PICALM"]
    PICALM -->|"contributes to"| Alzheimer["Alzheimer"]
    PICALM -.biomarker for.-> Aging["Aging"]
    PICALM -->|"contributes to"| APP["APP"]
    PICALM -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ENDOSOMES["ENDOSOMES"] -->|"contributes to"| PICALM
    ALZHEIMER["ALZHEIMER"] -->|"contributes to"| PICALM
    AMYLOID["AMYLOID"] -->|"contributes to"| PICALM
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PICALM

Outgoing (216)

Target	Relation	Type	Str
ds-f50762b67605	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Alzheimer's disease	risk_factor_for	disease	0.95
Clathrin-mediated Endocytosis	regulates	process	0.90
Autophagy	regulates	process	0.90
Cognitive Resilience	associated_with	phenotype	0.88
Tau Pathology	modulates	process	0.85
amyloid-beta clearance	regulates	process	0.85
Cognitive Aging	risk_factor_for	phenotype	0.80
oxidative stress response	participates_in	pathway	0.80
Gestational Diabetes	risk_factor_for	disease	0.75
Impaired Glucose Tolerance	protects_against	disease	0.72
APOE	associated_with	gene	0.70
Glucose Metabolism	involved_in	process	0.70
microglia	expressed_in	cell_type	0.70
endothelial cells	expressed_in	cell_type	0.70
TAU	interacts_with	gene	0.65
LRP1	interacts_with	gene	0.65
TAU	exacerbates	protein	0.65
APP	causes	gene	0.65
AKT	causes	gene	0.65
AKT	activates	gene	0.65
Alzheimer	contributes_to	disease	0.65
Dementia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ALS	regulates	disease	0.65
AMYLOID	regulates	protein	0.65
AMYLOID	causes	protein	0.65
APOPTOSIS	activates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
MAPK	causes	gene	0.65
ERK	regulates	gene	0.65
CD2AP	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
APP	contributes_to	gene	0.60
TNF	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
LPL	associated_with	gene	0.60

Incoming (199)

Source	Relation	Type	Str
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
GENES	associated_with	gene	0.80
SORL1	associated_with	gene	0.70
CLU	associated_with	gene	0.70
CR1	associated_with	gene	0.70
ROS	regulates	phenotype	0.65
MAPK	treats	gene	0.65
PLD3	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
APP	associated_with	gene	0.60
CLUSTERIN	associated_with	gene	0.60
TAU	associated_with	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	associated_with	entity	0.60
ABI3	associated_with	entity	0.60
ADAM17	associated_with	entity	0.60
APOE	associated_with	entity	0.60
CD2AP	associated_with	entity	0.60
CD33	associated_with	entity	0.60
CTSB	associated_with	entity	0.60
CTSH	associated_with	entity	0.60
EED	associated_with	entity	0.60
GRN	associated_with	entity	0.60
INPP5D	associated_with	entity	0.60
LILRB2	associated_with	entity	0.60
ABCA7	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
TAU	activates	gene	0.60
LRP1	activates	gene	0.60
TMEM106B	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PICALM

Understanding Entity Pages

Summary

Wiki Pages (21)

PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein

Alzheimer's Disease

Amyloid Cascade Pathway

Gene-Mechanism-Therapy Causal Chains

Tauopathies

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Amyloid-Beta Aggregation and Plaque Formation

genetics

Synaptic Plasticity Deficits in Neurodegeneration

neurovascular-dysfunction

AD Biomarker-to-Mechanism Mapping

Sporadic Alzheimer's Disease Pathway

CBS/PSP Genetic Architecture

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CR1 Gene — Complement Component 1q Receptor

Ferroptotic Neurons

Biomarkers of Alzheimer Disease

Endolysosomal Trafficking Defects in Neurodegeneration

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain