gene

PICALM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PICALM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

492Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

Gene profile: PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein, key AD risk gene involved in clathrin-mediated endocytosis

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🧬 Gene Info

Gene Symbol	PICALM
Full Name	Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome	10q24.2
Function	is a gene located on chromosome 10q24.
Primary Expression	Brain, Blood cells, Heart, Lung
Molecular Weight	70 kDa
Amino Acids	652 aa
Exons	21
Pathways	Amyloid, Autophagy, Clathrin-mediated Endocytosis, Complement, Glucose Metabolism
UniProt ID	Q7Z417
NCBI Gene ID	81501
Ensembl ID	ENSG00000021762
OMIM	610004
GeneCards	PICALM
Human Protein Atlas	PICALM
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cognitive Resilience
Interactions	ABCA1, ABCA7, Actin, AD, AKT, ALZHEIMER
SciDEX Hypotheses	APOE4-Microglial Lipid Metabolism Correction
KG Connections	492 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PICALM — AlphaFold Q7Z417 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PICALM["PICALM"]
    PICALM -->|"contributes to"| Alzheimer["Alzheimer"]
    PICALM -.biomarker for.-> Aging["Aging"]
    PICALM -->|"contributes to"| APP["APP"]
    PICALM -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ENDOSOMES["ENDOSOMES"] -->|"contributes to"| PICALM
    ALZHEIMER["ALZHEIMER"] -->|"contributes to"| PICALM
    AMYLOID["AMYLOID"] -->|"contributes to"| PICALM
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PICALM

Outgoing (234)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PICALM	data_in	dataset_row	0.00
ad_genetic_risk_loci:PICALM	data_in	dataset_row	0.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer's disease	associated_with	disease	0.95
clathrin-mediated endocytosis	regulates	process	0.90
Clathrin-mediated Endocytosis	regulates	process	0.90
Autophagy	regulates	process	0.90
Cognitive Resilience	associated_with	phenotype	0.88
amyloid-beta clearance	regulates	process	0.85
Tau Pathology	modulates	process	0.85
Cognitive Aging	risk_factor_for	phenotype	0.80
oxidative stress response	participates_in	pathway	0.80
Gestational Diabetes	risk_factor_for	disease	0.75
Impaired Glucose Tolerance	protects_against	disease	0.72
STING	expresses	gene	0.70
TAU	mediates	gene	0.70
TAU	causes	gene	0.70
TAU	markers	gene	0.70
STING	associated_with	gene	0.70
VPS35	associated_with	gene	0.70
RELN	protects_against	gene	0.70
RELN	markers	gene	0.70
PSEN1	expresses	gene	0.70
Alzheimer's disease	risk_factor_for	disease	0.70
APOE	associated_with	gene	0.70
endosomal trafficking	regulates	pathway	0.70
endothelial cells	expressed_in	cell_type	0.70
microglia	associated_with	cell_type	0.70
lipid droplet formation	causes	mechanism	0.70
Glucose Metabolism	involved_in	process	0.70
microglia	expressed_in	cell_type	0.70
Neuroinflammation	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
ALS	regulates	disease	0.65
AMYLOID	regulates	protein	0.65
AMYLOID	causes	protein	0.65
APOPTOSIS	activates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
MAPK	causes	gene	0.65
ERK	regulates	gene	0.65
APP	causes	gene	0.65
AKT	causes	gene	0.65
AKT	activates	gene	0.65
TAU	interacts_with	gene	0.65

Incoming (258)

Source	Relation	Type	Str
ad_genetic_risk_loci:PICALM	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:PICALM	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ALZHEIMER DISEASE	associated_with	gene	0.80
GENES	associated_with	gene	0.80
LDLR	activates	gene	0.70
GSK3B	associated_with	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
NEURONS	interacts_with	cell_type	0.70
MAPT	markers	gene	0.70
APOE	protects_against	gene	0.70
CLU	markers	gene	0.70
APOE	markers	gene	0.70
MICROGLIA	expresses	cell_type	0.70
APP	expressed_in	gene	0.70
ENDOTHELIAL	mediates	cell_type	0.70
ENDOTHELIAL	regulates	cell_type	0.70
CR1	associated_with	gene	0.70
SORL1	associated_with	gene	0.70
CLU	associated_with	gene	0.70
ROS	regulates	phenotype	0.65
MAPK	treats	gene	0.65
MS4A6A	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
BIN1	expressed_in	gene	0.60
CD2AP	expressed_in	gene	0.60
AD	interacts_with	gene	0.60
CLU	causes	gene	0.60
AΒ	activates	gene	0.60
AD	activates	gene	0.60
AΒ	enhances	gene	0.60
ABCA1	enhances	gene	0.60
CD2AP	enhances	gene	0.60
CLU	expressed_in	gene	0.60
CR1	expressed_in	gene	0.60
EPHA1	expressed_in	gene	0.60
DLG2	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
EPHA1	interacts_with	gene	0.60
FERMT2	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60
MEF2C	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
MAPT	associated_with	gene	0.60
ERK1	activates	gene	0.60
JNK	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-Microglial Lipid Metabolism Correction	0.000	-	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (3)

Scientific analyses that reference this entity

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

Variant Annotation and Prioritization of AD Risk Loci

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.862

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-03 | 5 hypotheses Top: 0.606

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.92 · 2026-04-03

Related Research

Hypotheses and analyses mentioning PICALM in their description or question text

No additional research found

PICALM

Understanding Entity Pages

Summary

Wiki Pages (3)

PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein

PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal Chain

PICALM Protein

Pathway Diagram

Outgoing (234)

Incoming (258)

Targeting Hypotheses (1)

Mentioning Analyses (3)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Variant Annotation and Prioritization of AD Risk Loci

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Experiments (0)

Related Papers (0)

Debates (4)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Which non-coding variants at AD GWAS loci have functional evidence for gene regu

Does the BIN1 non-coding variant mechanism provide a druggable target, or is tra

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

Related Research