concept

MTORC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTORC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1948Connections

6Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

MTORC1 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ADH, ALS. Connected to 1023 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MTORC1
Key Genes/Proteins	4EBP1, 4EBP1/2, 4EBP2, ABCA1, ABL1, ACC1
Related Diseases	AD, ADH
Related Pathways	Adaptive Immunity

Pathway Diagram

graph TD
    MTORC1["MTORC1"]
    MTORC1 -->|"inhibits"| ULK1["ULK1"]
    MTORC1 -->|"contributes to"| protein_synthesis["protein synthesis"]
    MTORC1 -->|"inhibits"| autophagy["autophagy"]
    MTORC1 -->|"inhibits"| TFEB["TFEB"]
    MTORC1 -->|"inhibits"| AUTOPHAGY["AUTOPHAGY"]
    MTORC1 -->|"activates"| lipogenesis["lipogenesis"]
    PRKAA["PRKAA"] -->|"inhibits"| MTORC1
    endocytosis["endocytosis"] -->|"activates"| MTORC1
    alpha_synuclein["alpha-synuclein"] -->|"activates"| MTORC1
    AKT["AKT"] -->|"activates"| MTORC1
    RAPAMYCIN["RAPAMYCIN"] -->|"inhibits"| MTORC1
    raptor["raptor"] -->|"activates"| MTORC1
    TSC2["TSC2"] -->|"inhibits"| MTORC1
    STING1["STING1"] -->|"activates"| MTORC1

Outgoing (1127)

Target	Relation	Type	Str
MTORC1	encodes	protein	0.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Mtor	activates	pathway	1.00
Cancer	interacts_with	disease	1.00
MTOR	activates	gene	1.00
Als	interacts_with	disease	1.00
Mtor	interacts_with	pathway	1.00
Inflammation	activates	disease	1.00
Tumor	activates	disease	1.00
Mtor	associated_with	pathway	1.00
AUTOPHAGY	inhibits	pathway	1.00
CANCER	activates	gene	1.00
MTOR	inhibits	gene	1.00
AKT	activates	gene	1.00
autophagy	inhibits	pathway	1.00
Cancer	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Mtor	inhibits	pathway	1.00
Mtor	regulates	pathway	1.00
CANCER	interacts_with	gene	1.00
AKT	regulates	gene	1.00
Autophagy	regulates	pathway	1.00
MTOR	interacts_with	gene	1.00
Cancer	inhibits	disease	0.95
mRNA Translation	activates	process	0.95
Cellular Growth	regulates	process	0.95
SREBP1	upregulates	protein	0.95
Inflammation	therapeutic_target	disease	0.95
TFEB	upstream_of	protein	0.95
Aging	therapeutic_target	disease	0.95
Cell Growth	regulates	process	0.95
mTOR Signaling	activates	pathway	0.95
Amino Acid Sensing	involved_in	process	0.95
Apoptosis	associated_with	process	0.95
Als	regulates	disease	0.95
Cancer	regulates	disease	0.95
Chondrocytes	expressed_in	cell_type	0.95
Mtdna Replication	regulates	process	0.95
Fibrosis	therapeutic_target	disease	0.95
PP2Ac	inhibits	protein	0.90
ULK1	regulates	protein	0.90
TFEB	inhibits	gene	0.90
anabolism	promotes	process	0.90
Anabolic Processes	regulates	process	0.90

Incoming (821)

Source	Relation	Type	Str
MTORC1	encodes	gene	0.00
AUTOPHAGY	activates	gene	1.00
AMPK	activates	gene	1.00
KLHL22	activates	protein	0.95
SLC38A9	mediates	protein	0.95
MTOR	component_of	gene	0.95
Rapamycin	inhibits	drug	0.95
Lysosomal Cholesterol	activates	compound	0.95
RAG	activates	protein	0.95
Rapamycin	targets	drug	0.95
SESTRIN2	inhibits	protein	0.95
SLC38A9	activates	protein	0.95
Amino Acids	activates	compound	0.95
nutrient levels	regulates	phenotype	0.90
endocytosis	activates	pathway	0.90
AKT	activates	gene	0.90
growth factors	regulates	phenotype	0.90
RRAGA	activates	gene	0.90
rapamycin	targets	drug	0.90
TSC2	inhibits	gene	0.90
Gi/o-coupled receptors	inhibits	mechanism	0.90
alpha-synuclein	activates	protein	0.90
Endocytosis	activates	process	0.90
RPTOR	regulates	gene	0.90
ARF1	activates	protein	0.90
PRKAA	inhibits	protein	0.90
RPTOR	component_of	gene	0.90
trehalose	inhibits	drug	0.90
PI3K	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
AUTOPHAGY	regulates	gene	0.90
PI3K/Akt Pathway	regulates	pathway	0.88
Pterostilbene	inhibits	compound	0.88
RAPAMYCIN	inhibits	drug	0.87
RRAGD	interacts_with	protein	0.85
SLC38A9	interacts_with	protein	0.85
LL37	activates	protein	0.85
ERN1	activates	gene	0.85
raptor	activates	protein	0.85
PI3K/AKT	regulates	pathway	0.85
STING1	activates	protein	0.82
GABARAP	inhibits	protein	0.82
TSC2	inhibits	protein	0.80
PRKAA2	inhibits	gene	0.80
MAP1LC3	regulates	gene	0.80
Arginine	activates	compound	0.80
LC3	regulates	gene	0.80
FLCN-FNIP Complex	inhibits	protein	0.80
NEURODEGENERATION	activates	gene	0.80

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
mTORC1 Reactivation as Autophagy-Senescence Divergence Point	0.682	molecular-biology	What is the optimal therapeutic window t
mTORC1 displacement from lysosomal surface enables calcineur	0.650	neurodegeneration	What determines the specificity of calci
mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuc	0.640	neurodegeneration	-
Impaired TFEB/TFE3 Nuclear Translocation Due to mTORC1 Hyper	0.603	neurodegeneration	What mechanisms underlie neuronal resist
mTORC1 Hyperactivation Impairs Autophagic Flux and Drives Se	0.600	neurodegeneration	What molecular mechanisms drive microgli

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in	0.578	neurodegeneration	What specific autophagy pathways are def

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning MTORC1 in their description or question text

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericyte

Score: 0.578 · neurodegeneration · 2026-04-25

DNA damage and SASP signaling keep initiation suppressed, producing a durable upstream autophagy defect.

MTORC1

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (1127)

Incoming (821)

Targeting Hypotheses (6)

Mentioning Analyses (6)

Does RGS6 upregulation or D2 autoreceptor modulation prevent neurodegeneration i

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Does TFEB dysfunction causally drive neurodegeneration or represent compensatory

What determines the specificity of calcium-dependent PPP3/calcineurin activation

How do different organelle-specific autophagy pathways coordinate during neurode

What is the optimal therapeutic window timing for autophagy enhancement versus s

Experiments (0)

Related Papers (0)

Debates (6)

The sequential therapy hypothesis depends on identifying when autophagy failure

The abstract mentions multiple organelles synchronously present structural deran

While the study establishes that trehalose-induced lysosomal permeabilization ac

The core causation versus correlation debate remains unresolved despite being ce

While RGS6 deficiency causes Parkinson's-like pathology, whether enhancing RGS6

The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu

Related Research

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericyte