protein

OCCLUDIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OCCLUDIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

0Analyses

39Outgoing

50Incoming

Summary

Page for Occludin Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	OCCLUDIN
Molecular Weight	65.4 kDa
Amino Acids	522 aa
Pathways	TIGHT_JUNCTION
GeneCards	OCCLUDIN
Human Protein Atlas	OCCLUDIN
Interactions	MLCK, PPAR, TUBULIN, Proteins, IL-6, TNF
KG Connections	91 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    OCCLUDIN["<b>OCCLUDIN</b>"]
    TIGHT_JUNCTION["TIGHT_JUNCTION"]
    OCCLUDIN -->|"participates_in"| TIGHT_JUNCTION
    ENDOTHELIAL_CELLS["ENDOTHELIAL_CELLS"]
    OCCLUDIN -->|"expressed_in"| ENDOTHELIAL_CELLS
    EPITHELIAL_CELLS["EPITHELIAL_CELLS"]
    OCCLUDIN -->|"expressed_in"| EPITHELIAL_CELLS
    MLCK(["MLCK"])
    OCCLUDIN -->|"activates"| MLCK
    OCLN(["OCLN"])
    OCCLUDIN -->|"co_discussed"| OCLN
    PPAR(["PPAR"])
    OCCLUDIN -->|"activates"| PPAR
    IL_6(["IL-6"])
    IL_6 -->|"activates"| OCCLUDIN
    TNF(["TNF"])
    TNF -->|"activates"| OCCLUDIN
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"activates"| OCCLUDIN
    style OCCLUDIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (41)

Target	Relation	Type	Str
TIGHT_JUNCTION	participates_in	pathway	0.72
ENDOTHELIAL_CELLS	expressed_in	cell_type	0.64
EPITHELIAL_CELLS	expressed_in	cell_type	0.64
MLCK	activates	gene	0.50
OCLN	co_discussed	gene	0.50
PPAR	activates	protein	0.50
STROKE	co_discussed	gene	0.50
Ubiquitin-Proteasome	activates	pathway	0.50
Cerebrovascular	activates	pathway	0.50
Endothelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
TJP1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
TUBULIN	activates	protein	0.50
Stem Cell	activates	cell_type	0.50
SCIN	activates	concept	0.50
Cell Division	activates	pathway	0.50
Receptor Tyrosine Kinase	activates	pathway	0.50
CLDN1	activates	concept	0.50
inflammation	regulates	pathway	0.50
TUMOR	regulates	disease	0.50
TNF-α	regulates	concept	0.50
CDH1	inhibits	concept	0.50
inflammation	activates	pathway	0.50
COPD	activates	disease	0.50
Proteins	activates	protein	0.50
Microrna	activates	pathway	0.50
ENDOTHELIAL	interacts_with	concept	0.50
TNF-α	activates	concept	0.50
BCL-2	expressed_in	protein	0.50
Proteins	expressed_in	protein	0.50
Proteins	associated_with	protein	0.50
apoptosis	activates	process	0.50
Hippocampus	inhibits	entity	0.50
GENE EXPRESSION	inhibits	concept	0.50
CEREBELLUM	activates	concept	0.50
IL-17	activates	concept	0.50
DIABETES	inhibits	disease	0.50
ANGPT1	inhibits	concept	0.50

Incoming (58)

Source	Relation	Type	Str
OCLN	encodes	gene	0.95
IL-6	activates	protein	0.50
TNF	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
APP	activates	gene	0.50
CLAUDIN-5	co_discussed	protein	0.50
GENES	co_discussed	gene	0.50
LRP1	co_discussed	gene	0.50
HIF1A	activates	gene	0.50
Autophagy	activates	process	0.50
OCLN	activates	gene	0.50
CAV1	activates	gene	0.50
CLDN5	activates	gene	0.50
BECN1	activates	gene	0.50
UBIQUITIN	activates	protein	0.50
CLAUDIN-5	expressed_in	protein	0.50
ACTB	activates	gene	0.50
ATG14	activates	gene	0.50
H2AX	activates	gene	0.50
UVRAG	activates	gene	0.50
SQSTM1	activates	gene	0.50
STK11	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
PIK3C3	activates	gene	0.50
GAPDH	activates	gene	0.50
CYP11A1	activates	gene	0.50
TUBB3	activates	gene	0.50
HDAC6	activates	gene	0.50
CDC42	activates	gene	0.50
MAP3K5	activates	gene	0.50
CASP3	activates	gene	0.50
GJA1	activates	gene	0.50
VIMENTIN	activates	protein	0.50
LAMP1	activates	protein	0.50
RAC1	activates	protein	0.50
ARNT	regulates	gene	0.50
BMAL1	regulates	protein	0.50
OCLN	regulates	gene	0.50
CRY1	regulates	gene	0.50
OCLN	inhibits	gene	0.50
OCLN	expressed_in	gene	0.50
OCLN	associated_with	gene	0.50
OCLN	interacts_with	gene	0.50
IL-1Β	activates	protein	0.50
PHAGOCYTOSIS	activates	gene	0.50
LRP1	activates	gene	0.50
CLAUDIN-5	activates	protein	0.50
CLAUDIN-5	inhibits	protein	0.50
MLCK	activates	gene	0.50
NADPH	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OCCLUDIN

Understanding Entity Pages

Summary

Wiki Pages (20)

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Blood-Brain Barrier Biology and Crossing Strategies

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Traumatic Brain Injury and Neurodegeneration Pathway

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Gut-Brain Axis in Neurodegeneration

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KRIT1 — Krev Interaction Trapped 1 (CCM1)

cGMP Signaling Pathway in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

Neuroinflammation in Amyotrophic Lateral Sclerosis

vegfr-signaling-neurodegeneration

Blood-Brain Barrier Breakdown in Neurodegeneration

Cerebral Ischemia Pathway in Neurodegeneration

blood-brain-barrier-endothelial-cells