gene

S100B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S100B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

3Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

S100B is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, activates, regulates. Associated with ALS, Aging, Als. Connected to 152 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	S100B
Full Name	S100 Calcium Binding Protein B
Chromosome	21q22.3
Protein Family	S100 EF-hand calcium binding proteins
Function	is a gene encoding a calcium-binding protein of the S100 family, playing crucial roles in neuronal function, astrocyte biology, and neuroinflammation.
Molecular Weight	10.5 kDa
Amino Acids	92 aa
Pathways	PI3K
UniProt ID	[P16401](https://www.uniprot.org/uniprot/P16401)
Ensembl ID	ENSG00000122574
OMIM	176990
GeneCards	S100B
Human Protein Atlas	S100B
Associated Diseases	Als, Cardiovascular, Glioma, Inflammation, Ms, Neurodegeneration
Interactions	Adiponectin, ADIPOQ, ALZHEIMER, AMYLOID, AND, APOPTOSIS
SciDEX Hypotheses	S100B as Active Pathogenic BBB-Disrupting Signal v
KG Connections	364 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    S100B["S100B
Calcium-binding protein"]
    
    S100B -->|"activates"| Neuroinflammation["Neuroinflammation
Glial activation"]
    S100B -->|"biomarker_for"| TBI["Traumatic Brain Injury
Acute neural damage"]
    S100B -->|"activates"| ALS["ALS
Motor neuron disease"]
    S100B -->|"activates"| MS["Multiple Sclerosis
Demyelinating disease"]
    
    S100B -->|"activates"| C1Q["C1Q
Complement activation"]
    S100B -->|"activates"| HMGB1["HMGB1
Damage-associated
molecular pattern"]
    S100B -->|"activates"| TGM2["TGM2
Transglutaminase 2"]
    
    Neuroinflammation -->|"leads_to"| Microglial_activation["Microglial Activation
Pro-inflammatory state"]
    C1Q -->|"triggers"| Complement_cascade["Complement Cascade
Synaptic pruning"]
    HMGB1 -->|"promotes"| Cytokine_release["Cytokine Release
IL-1beta, TNF-alpha"]
    
    S100B -->|"biomarker_for"| BDNF["BDNF
Neuroprotective factor"]
    S100B -->|"associated_with"| Aging["Aging
Cellular senescence"]
    
    Microglial_activation -->|"causes"| Synaptic_loss["Synaptic Loss
Neuronal dysfunction"]
    Complement_cascade -->|"results_in"| Synaptic_loss
    Cytokine_release -->|"contributes_to"| Neurodegeneration["Neurodegeneration
Progressive cell death"]
    
    Aging -->|"accelerates"| Neuroinflammation
    Synaptic_loss -->|"leads_to"| Neurodegeneration
    
    style S100B fill:#006494
    style BDNF fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style TBI fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style C1Q fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style Aging fill:#5d4400

Outgoing (246)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Neuroinflammation	associated_with	process	0.80
Major Depressive Disorder	biomarker_for	disease	0.80
astrocyte	expressed_in	cell_type	0.80
Inflammation	associated_with	disease	0.75
astrocyte reactivity	biomarker_for	phenotype	0.70
Glioma	implicated_in	disease	0.65
HMGB1	inhibits	gene	0.65
ALS	activates	disease	0.65
Tumor	implicated_in	disease	0.65
TAU	associated_with	gene	0.65
Cardiac	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Ischemia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
BBB_integrity	disrupts	process	0.65
Als	expressed_in	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Ms	protects_against	disease	0.65
Glaucoma	protects_against	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Longevity	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Stroke	activates	disease	0.65
Stroke	causes	disease	0.65
DAM microglia	expressed_in	cell_type	0.65
Tumor	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ASTROCYTES	produces	cell_type	0.65
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60

Incoming (118)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
h-3bfa414a	targets_gene	hypothesis	0.90
BDNF	associated_with	gene	0.66
ASTROCYTE	associated_with	gene	0.65
GFAP	associated_with	gene	0.65
FNDC5	biomarker_for	gene	0.60
TNF	activates	gene	0.60
VIMENTIN	biomarker_for	gene	0.60
TGM2	activates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
EGR1	activates	gene	0.60
FOS	activates	gene	0.60
NTRK2	activates	gene	0.60
BDNF	activates	gene	0.60
GAD1	activates	gene	0.60
NTF3	activates	gene	0.60
CALB2	activates	gene	0.60
FGF21	biomarker_for	gene	0.60
PVALB	activates	gene	0.60
GFAP	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
CALB1	activates	gene	0.60
APP	activates	gene	0.60
AGING	biomarker_for	gene	0.60
GHRL	activates	gene	0.60
PGRN	biomarker_for	gene	0.60
IL-6	biomarker_for	gene	0.60
PTX3	activates	gene	0.60
MAPK1	associated_with	gene	0.60
NTF3	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
ADIPOQ	activates	gene	0.60
LDH	activates	gene	0.60
PLAU	biomarker_for	gene	0.60
FGF23	biomarker_for	gene	0.60
GPNMB	activates	gene	0.60
BDNF	biomarker_for	gene	0.60
C1Q	activates	gene	0.60
CX3CL1	biomarker_for	gene	0.60
VIM	biomarker_for	gene	0.60
APP	co_discussed	gene	0.60
CXCL10	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
GFAP	biomarker_for	gene	0.60
MMP9	causes	gene	0.60
GFAP	regulates	gene	0.60
C3	activates	gene	0.60
C3	biomarker_for	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dependent S100B Release from Astrocyte End-Feet as a	0.725	-	What blood-brain barrier permeability ch
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Sign	0.380	synaptic-biology	What determines the selectivity of compl

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning S100B in their description or question text

No additional research found

S100B

Understanding Entity Pages

Summary

Wiki Pages (3)

S100B Gene

S100B Protein - Astrocyte Biomarker

S100B Protein

Pathway Diagram

Outgoing (246)

Incoming (118)

Targeting Hypotheses (3)

Mentioning Analyses (3)

What blood-brain barrier permeability changes serve as early biomarkers for neur

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

scRNA-seq Processing and Cell Type Annotation of AD Brain

Experiments (0)

Related Papers (0)

Debates (5)

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

What blood-brain barrier permeability changes serve as early biomarkers for neur

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Can standardized scRNA-seq processing and automated annotation identify novel ce

Does the hybrid DAM + interferon-response microglial population represent a nove

Related Research