S100B

Understanding Entity Pages

This page aggregates everything SciDEX knows about S100B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

S100B is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, activates, regulates. Associated with ALS, Aging, Als. Connected to 152 entities in the SciDEX knowledge graph.

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flowchart TD
    S100B["S100B<br/>Calcium-binding protein"]
    
    S100B --|"activates"|--> Neuroinflammation["Neuroinflammation<br/>Glial activation"]
    S100B --|"biomarker_for"|--> TBI["Traumatic Brain Injury<br/>Acute neural damage"]
    S100B --|"activates"|--> ALS["ALS<br/>Motor neuron disease"]
    S100B --|"activates"|--> MS["Multiple Sclerosis<br/>Demyelinating disease"]
    
    S100B --|"activates"|--> C1Q["C1Q<br/>Complement activation"]
    S100B --|"activates"|--> HMGB1["HMGB1<br/>Damage-associated<br/>molecular pattern"]
    S100B --|"activates"|--> TGM2["TGM2<br/>Transglutaminase 2"]
    
    Neuroinflammation --|"leads_to"|--> Microglial_activation["Microglial Activation<br/>Pro-inflammatory state"]
    C1Q --|"triggers"|--> Complement_cascade["Complement Cascade<br/>Synaptic pruning"]
    HMGB1 --|"promotes"|--> Cytokine_release["Cytokine Release<br/>IL-1beta, TNF-alpha"]
    
    S100B --|"biomarker_for"|--> BDNF["BDNF<br/>Neuroprotective factor"]
    S100B --|"associated_with"|--> Aging["Aging<br/>Cellular senescence"]
    
    Microglial_activation --|"causes"|--> Synaptic_loss["Synaptic Loss<br/>Neuronal dysfunction"]
    Complement_cascade --|"results_in"|--> Synaptic_loss
    Cytokine_release --|"contributes_to"|--> Neurodegeneration["Neurodegeneration<br/>Progressive cell death"]
    
    Aging --|"accelerates"|--> Neuroinflammation
    Synaptic_loss --|"leads_to"|--> Neurodegeneration
    
    style S100B fill:#006494
    style BDNF fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style TBI fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style C1Q fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style Aging fill:#5d4400