gene

MERTK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MERTK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

262Connections

1Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

MER Proto-Oncogene, Tyrosine Kinase: receptor tyrosine kinase in TAM family involved in microglial phagocytosis and neurodegeneration

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MERTK
Full Name	MERTK - MER Tyrosine Kinase
Aliases	Page for MERTK Protein
Chromosome	2q14.1
Protein Type	Gene
Primary Expression	macrophages, microglia, photoreceptor cells, and neurons, where it mediates the clearance of apoptotic cells and cellular debris through recognition o
Molecular Weight	110 kDa
Amino Acids	998 aa
Exons	20
Pathways	NF-κB, PI3K, MAPK
UniProt ID	Q12866
NCBI Gene ID	10488
Ensembl ID	ENSG00000153208
GeneCards	MERTK
Human Protein Atlas	MERTK
Associated Diseases	Aging, Alzheimer, Diabetes, Fibrosis, Hepatitis, Infection
Known Drugs/Compounds	Fc-DN30, HDAC Inhibitors
Interactions	ADAM8, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
KG Connections	262 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — MERTK Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

3TCP — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q12866 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MERTK - MER Tyrosine Kinase

gene · 2621 words

→

MERTK Protein - MER Tyrosine Kinase

protein · 735 words

→

Pathway Diagram

graph TD
    MERTK["MERTK"]
    Neuroinflammation{"Neuroinflammation"}
    MERTK -->|"expressed in"| Neuroinflammation
    Ms{"Ms"}
    MERTK -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    MERTK -->|"regulates"| Inflammation
    Lymphoma{"Lymphoma"}
    MERTK -->|"activates"| Lymphoma
    MERTK -->|"activates"| Ms
    Atherosclerosis{"Atherosclerosis"}
    MERTK -->|"activates"| Atherosclerosis
    ERK["ERK"]
    MERTK -->|"expressed in"| ERK
    AKT["AKT"]
    MERTK -->|"activates"| AKT
    APOPTOSIS["APOPTOSIS"]
    MERTK -->|"activates"| APOPTOSIS
    MAF["MAF"]
    MERTK -->|"activates"| MAF
    Akt(["Akt"])
    MERTK -->|"activates"| Akt
    Apoptosis(["Apoptosis"])
    MERTK -->|"activates"| Apoptosis
    STAT6["STAT6"]
    STAT6 -->|"expressed in"| MERTK
    EPHA4["EPHA4"]
    EPHA4 -->|"expressed in"| MERTK
    MTOR["MTOR"]
    MTOR -->|"activates"| MERTK
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| MERTK
    ERK -->|"expressed in"| MERTK
    style MERTK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (168)

Target	Relation	Type	Str
microglial phagocytic function	regulates	process	0.90
Efferocytosis	regulates	phenotype	0.90
Efferocytosis	activates	phenotype	0.90
Efferocytosis	mediates	process	0.85
neuroinvasive viral infection	decreases_risk	disease	0.70
viral neuroinvasion	decreases_risk	phenotype	0.70
microglial disease-associated states	regulates	phenotype	0.70
microglial neuroinflammatory response	regulates	phenotype	0.70
Apoptosis	activates	pathway	0.70
microglial inflammation	modulates	mechanism	0.70
amyloid phagocytosis	regulates	process	0.70
Phagocytic clearance	regulates	process	0.70
neuroinvasive viral susceptibility	protective_against	phenotype	0.70
BBB_integrity	decreases_risk	pathway	0.70
MICROGLIA	treats	cell_type	0.65
Lymphoma	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Ms	expressed_in	disease	0.65
Senescence	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	regulates	disease	0.65
Infection	implicated_in	disease	0.65
Atherosclerosis	activates	disease	0.65
Cardiac	activates	disease	0.65
Fibrosis	implicated_in	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Sepsis	activates	disease	0.65
Hepatitis	implicated_in	disease	0.65
Diabetes	implicated_in	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
PDK4	regulates	gene	0.60
GPR109A	activates	gene	0.60
NDRG2	regulates	gene	0.60
C1S	regulates	gene	0.60
MTOR	activates	gene	0.60
IRF1	regulates	gene	0.60
SESN1	regulates	gene	0.60
SIRPA	regulates	gene	0.60
EPHA4	expressed_in	gene	0.60
C1QB	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
CD47	regulates	gene	0.60

Incoming (94)

Source	Relation	Type	Str
Fc-DN30	activates	drug	0.70
MICROGLIA	interacts_with	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
ASTROCYTES	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
BAX/BCL2	activates	gene	0.60
LAMP2	activates	gene	0.60
LDL	activates	gene	0.60
ATP	activates	gene	0.60
IRF8	activates	gene	0.60
IL-1	activates	gene	0.60
MAPK	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
ADAM8	activates	gene	0.60
GPR109A	activates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
ADCY9	regulates	gene	0.60
C3	regulates	gene	0.60
AXL	associated_with	gene	0.60
GRN	associated_with	gene	0.60
AXL	activates	gene	0.60
GRN	activates	gene	0.60
AXL	interacts_with	gene	0.60
AXL	regulates	gene	0.60
C9ORF72	regulates	gene	0.60
GRN	regulates	gene	0.60
MAPT	regulates	gene	0.60
GRN	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
ITGAM	regulates	gene	0.60
HLA	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
COMPLEMENT	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TAM Receptor (MERTK/AXL) Cross-Regulation	0.540	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning MERTK in their description or question text

No additional research found

MERTK

Understanding Entity Pages

Summary

Wiki Pages (2)

MERTK - MER Tyrosine Kinase

MERTK Protein - MER Tyrosine Kinase

Pathway Diagram

Outgoing (168)

Incoming (94)

Targeting Hypotheses (1)

Mentioning Analyses (6)

What are the mechanisms by which microglial senescence contributes to ALS pathol

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

Experiments (0)

Related Papers (0)

Debates (8)

Debate: TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fu

Investigate how microglial senescence drives ALS progression through inflammatio

What are the mechanisms by which microglial senescence contributes to ALS pathol

Which cell types show the greatest vulnerability in Alzheimer's disease accordin

The debate identified APOE4 astrocytes as potential senescence drivers but did n

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

While the study shows HDAC1/2 deletion improves amyloid clearance and cognition,

Related Research