protein

CASP6PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	CASP6PROTEIN
Protein Family	Caspase family (C14 clan, executioner caspase)
Protein Type	Protease
Function	is an executioner cysteine-aspartate protease encoded by the CASP6 gene.
Subcellular Localization	Alzheimer's disease tangles, and cleaves [huntingtin](/proteins/huntingtin-prote
Molecular Weight	34 kDa
Amino Acids	293 aa
GeneCards	CASP6PROTEIN
Human Protein Atlas	CASP6PROTEIN
Self-activation capability	Unlike caspase-3/7, procaspase-6 can undergo intramolecular self-cleavage at Asp179, enabling activation without upstream caspases
Zinc inhibition site	An allosteric zinc-binding site (His121, Cys163, Cys263) allows physiological regulation by zinc ions
Conformational flexibility	The active-site loop (L2') adopts an extended conformation not seen in other executioner caspases, contributing to distinct substrate specificity
Associated Diseases	Aging, Alzheimer, Alzheimer Disease, Dementia, Huntington Disease, Pyroptosis
Interactions	ALZHEIMER, BCL2A1, CANCER, CASP3, CASP8, CEBPB
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-6

protein · 1093 words

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Pathway Diagram

graph TD
    CASP6PROTEIN["CASP6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CASP6PROTEIN -->|"implicated_in"| neurodegeneration
    style CASP6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CASP6PROTEIN in their description or question text

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