protein

CASP6PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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🔬 Protein Info

Gene Symbol	CASP6PROTEIN
Protein Family	Caspase family (C14 clan, executioner caspase)
Protein Type	Protease
Function	is an executioner cysteine-aspartate protease encoded by the CASP6 gene.
Subcellular Localization	Alzheimer's disease tangles, and cleaves [huntingtin](/proteins/huntingtin-prote
Molecular Weight	34 kDa
Amino Acids	293 aa
GeneCards	CASP6PROTEIN
Human Protein Atlas	CASP6PROTEIN
Gene [@bhatt2012] CASP6 [@bhatt2020] UniProt	P55212
PDB	3OD5, 4FXO
Mol. Weight	~34 kDa (proenzyme), p18+p11 (active)
Associated Diseases	Aging, Alzheimer, Alzheimer Disease, Dementia, Huntington Disease, Pyroptosis
Interactions	DES, RIPK1, FADD, CEBPB, MCL1, MDM2
KG Connections	60 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-6

protein · 1093 words

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Pathway Diagram

graph TD
    CASP6PROTEIN["CASP6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CASP6PROTEIN -->|"implicated_in"| neurodegeneration
    style CASP6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity