gene

CASP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

CASP8 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Aging, Als, Autoimmune. Connected to 119 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	CASP8
Full Name	Caspase 8
Chromosome	2q33
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	20 kDa
Amino Acids	80 aa
Pathways	Akt, Nf-Κb, Pi3K, Toll-Like Receptor
UniProt ID	[Q14790](https://www.uniprot.org/uniprot/Q14790)
Ensembl ID	ENSG00000164040
GeneCards	CASP8
Human Protein Atlas	CASP8
Associated Diseases	Als, Autoimmune, Ms, Rheumatoid Arthritis
Known Drugs/Compounds	natural products
Interactions	SQSTM1, MMP2, CASP3, GBM, CDK4, MCL1
KG Connections	177 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP8["CASP8"]
    CASP8 -->|"target for"| Carcinoma["Carcinoma"]
    CASP8 -->|"target for"| Cancer["Cancer"]
    CASP8 -->|"target for"| Ms["Ms"]
    CASP8 -->|"target for"| Glioblastoma["Glioblastoma"]
    CASP8 -->|"target for"| Inflammation["Inflammation"]
    CASP8 -->|"target for"| Fibrosis["Fibrosis"]
    CASP8 -->|"target for"| Diabetes["Diabetes"]
    CASP8 -->|"interacts"| Als["Als"]
    TLR4["TLR4"] -->|"activates"| CASP8
    UBIQUITIN["UBIQUITIN"] -->|"activates"| CASP8
    TP53["TP53"] -->|"target for"| CASP8
    FAS["FAS"] -->|"interacts"| CASP8
    BCL2L1["BCL2L1"] -.biomarker for.-> CASP8
    BCL2["BCL2"] -->|"regulates"| CASP8
    PI3K["PI3K"] -->|"regulates"| CASP8

Outgoing (131)

Target	Relation	Type	Str
PANoptosis	component_of	process	0.95
Hepatic Apoptosis	mediates	process	0.90
apoptosis	mediates	process	0.90
TNFR1	interacts_with	gene	0.85
Depression	involved_in	disease	0.85
AKT	regulates	gene	0.70
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Lymphoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Autoimmune	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
SQSTM1	activates	gene	0.60
P62	therapeutic_target	gene	0.60
MMP2	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
GBM	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
MCL1	interacts_with	gene	0.60
CASP3	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
ATM	associated_with	gene	0.60
TRIM32	activates	gene	0.60
ZBP1	activates	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
FADD	interacts_with	gene	0.60
GSDMD	therapeutic_target	gene	0.60
RIPK1	therapeutic_target	gene	0.60
ZBP1	therapeutic_target	gene	0.60
MLKL	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60

Incoming (46)

Source	Relation	Type	Str
natural products	targets	compound	0.75
PI3K	regulates	gene	0.70
TLR4	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
TP53	therapeutic_target	gene	0.60
FAS	interacts_with	gene	0.60
FAS	therapeutic_target	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
BCL2	regulates	gene	0.60
TP53	regulates	gene	0.60
TLR4	regulates	gene	0.60
TNF	regulates	gene	0.60
CASP9	regulates	gene	0.60
STAT3	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
IKBKB	associated_with	gene	0.60
GBM	interacts_with	gene	0.60
MCL1	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
MMP2	interacts_with	gene	0.60
RAB7A	activates	gene	0.60
TNFSF10	activates	gene	0.60
TNFRSF1A	activates	gene	0.60
FYCO1	activates	gene	0.60
DR5	activates	gene	0.60
TRAIL	activates	gene	0.60
AKT1	activates	gene	0.60
RIPK3	activates	gene	0.60
TRIM32	activates	gene	0.60
ZBP1	activates	gene	0.60
CASP1	regulates	gene	0.60
CASP7	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
GENES	therapeutic_target	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
MAPK	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
SEPSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASP8

Understanding Entity Pages

Summary

Wiki Pages (21)

casp8

Cytochrome c Protein

Apoptosis in Neurodegeneration

CFLAR

CASP9 (Caspase 9)

CASP14 Gene

casp3

CASP2 Gene

Caspase-8 (CASP8)

FADD Gene

CASP10 Gene

caspase-8-protein

BID — BH3 Interacting Domain Death Agonist

CASP7 Gene

PANoptosis in Neurodegeneration

Neurofilament Heavy Chain (NfH)

Caspase-6

TNF Alpha Protein

BAG4