Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CBLN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CBLN2 in synaptic organization, cerebellar function, and neurodegenerative diseases
| Gene Symbol | CBLN2 |
| Chromosome | 16q22.1 |
| Primary Expression | various brain regions, particularly the cerebellum, hippocampus, and cerebral cortex, where it regulates synaptic connectivity and neural circuit deve |
| Molecular Weight | ~18 kDa |
| Amino Acids | 20 aa |
| Exons | 4 coding exons |
| Pathways | Activation |
| UniProt ID | Q9P293 |
| NCBI Gene ID | 55530 |
| Ensembl ID | ENSG00000164920 |
| GeneCards | CBLN2 |
| Human Protein Atlas | CBLN2 |
| Isoelectric Point | 8.2 |
| Disulfide Bonds | 4 cysteine residues |
| Post-translational | N-glycosylation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | Rb, GLUD1, GRID1, SYNAPSE |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CBLN2"]
N1["Als"]
N0 -->|"expressed in"| N1
N2["Schizophrenia"]
N0 -->|"expressed in"| N2
N3["Rb"]
N0 -->|"interacts with"| N3
N4["GLUD1"]
N4 -->|"interacts with"| N0
N5["GRID2"]
N5 -->|"expressed in"| N0
N6["GLUD2"]
N6 -->|"expressed in"| N0
N7["SYNAPSE"]
N7 -->|"interacts with"| N0
N8["GRID1"]
N8 -->|"interacts with"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 protein
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Rb | interacts_with | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||