gene

CBLN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CBLN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections
0Hypotheses
0Analyses
3Outgoing
5Incoming
0Experiments

Summary

CBLN2 in synaptic organization, cerebellar function, and neurodegenerative diseases

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🧬 Gene Info
Gene SymbolCBLN2
Chromosome16q22.1
Primary Expressionvarious brain regions, particularly the cerebellum, hippocampus, and cerebral cortex, where it regulates synaptic connectivity and neural circuit deve
Molecular Weight~18 kDa
Amino Acids20 aa
Exons4 coding exons
PathwaysActivation
UniProt IDQ9P293
NCBI Gene ID55530
Ensembl IDENSG00000164920
GeneCardsCBLN2
Human Protein AtlasCBLN2
Isoelectric Point8.2
Disulfide Bonds4 cysteine residues
Post-translationalN-glycosylation
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsRb, GLUD1, GRID1, SYNAPSE
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CBLN2 — AlphaFold Q9P293 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

CBLN2 Gene (Cerebellin 2)

gene · 2339 words

CBLN1 Gene

gene · 1688 words

GLUD2 Gene

gene · 1253 words

Rosehip Neurons

cell · 1143 words

Neurexin-1 Protein (NRXN1)

protein · 1106 words

Cerebellin-2 Protein

protein · 920 words

Pathway Diagram

flowchart TD
    N0["CBLN2"]
    N1["Als"]
    N0 -->|"expressed in"| N1
    N2["Schizophrenia"]
    N0 -->|"expressed in"| N2
    N3["Rb"]
    N0 -->|"interacts with"| N3
    N4["GLUD1"]
    N4 -->|"interacts with"| N0
    N5["GRID2"]
    N5 -->|"expressed in"| N0
    N6["GLUD2"]
    N6 -->|"expressed in"| N0
    N7["SYNAPSE"]
    N7 -->|"interacts with"| N0
    N8["GRID1"]
    N8 -->|"interacts with"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 protein
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (3)

TargetRelationTypeStr
Alsexpressed_indisease0.65
Schizophreniaexpressed_indisease0.65
Rbinteracts_withprotein0.60

Incoming (5)

SourceRelationTypeStr
GLUD1interacts_withgene0.60
GRID2expressed_ingene0.60
GLUD2expressed_ingene0.60
GRID1interacts_withgene0.60
SYNAPSEinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found