Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about grid2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GRID2 |
| Full Name | Glutamate Ionotropic Receptor Delta Type Subunit 2 |
| Protein Type | Receptor |
| Function | GRID2 (Glutamate Receptor Ionotropic Delta 2), also known as GluRδ2 or GluD2, is a member of the delta glutamate receptor family with critical roles in cerebellar function, synaptic plasticity, and mo |
| Molecular Weight | 115 kDa |
| Ensembl ID | ENSG00000128283 |
| GeneCards | GRID2 |
| Human Protein Atlas | GRID2 |
| Associated Diseases | Als |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRID2["GRID2"]
GRID2 -->|"activates"| Cancer["Cancer"]
GRID2 -->|"activates"| Tumor["Tumor"]
GRID2 -->|"expressed in"| Schizophrenia["Schizophrenia"]
GRID2 -->|"inhibits"| PDGFRA["PDGFRA"]
GRID2 -->|"activates"| NEURON["NEURON"]
GRID2 -->|"activates"| ERK["ERK"]
GRID2 -->|"activates"| RAS["RAS"]
GRID2 -->|"activates"| GRIK3["GRIK3"]
GRIK3 -->|"activates"| GRID2
ERK -->|"activates"| GRID2
SRC["SRC"] -->|"activates"| GRID2
GLUD1["GLUD1"] -->|"transports"| GRID2| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| PDGFRA | inhibits | gene | 0.60 |
| GRIK3 | activates | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| GLUD2 | transports | gene | 0.60 |
| GRID1 | expressed_in | gene | 0.60 |
| CBLN2 | expressed_in | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| MAPK7 | expressed_in | gene | 0.60 |
| RIPK2 | expressed_in | gene | 0.60 |
| UHRF1 | expressed_in | gene | 0.60 |
| RIPK2 | biomarker_for | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| RAS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| SYNAPSE | transports | gene | 0.60 |
| MAP | expressed_in | gene | 0.60 |
| MAPK | expressed_in | gene | 0.60 |
| MRPS31 | expressed_in | gene | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:GRID2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GRIK3 | activates | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| GLUD1 | transports | gene | 0.60 |
| ABCA7 | expressed_in | gene | 0.60 |
| ARF1 | expressed_in | gene | 0.60 |
| ATG7 | expressed_in | gene | 0.60 |
| E2F2 | expressed_in | gene | 0.60 |
| ELAVL1 | expressed_in | gene | 0.60 |
| ABCA7 | biomarker_for | gene | 0.60 |
| E2F2 | biomarker_for | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| G6PD | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:GRID2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||