CR

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

pharmacology | 2026-04-11 | 0 hypotheses

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

What is the therapeutic window between tau propagation inhibition and essential

neurodegeneration | 2026-04-06 | 5 hypotheses Top: 0.780

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.850

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive select

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

The debate highlighted that most promising targets (VAMP2, ESCRT, fascin-1) are

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate highlighted receptor desensitization as a critical concern for SPM re

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate highlighted that long-term CRISPR expression triggers immune response

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The study identifies KCNJ2 as a therapeutic target through CRISPR screening but

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

The abstract shows TYROBP deficiency is neuroprotective despite being required f

closed · Rounds: 4 · Score: 0.56 · 2026-04-15

Neuroinflammation and microglial priming in early Alzheimer's Disease

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence

Score: 0.893 · neurodegeneration · 2026-04-12

## Mechanistic Overview SIRT1 (Sirtuin 1), a class III NAD+-dependent histone deacetylase, functions as a master metabo

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Score: 0.892 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a type I transmembrane glycoprotein

ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

Score: 0.891 · alzheimers · 2026-04-02

## Mechanistic Overview ACSL4 (acyl-CoA synthetase long-chain family member 4) catalyzes the esterification of arachido

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.887 · neurodegeneration · 2026-04-16

## Mechanistic Overview The therapeutic hypothesis centers on the critical role of interferon-gamma (IFNγ), encoded by

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL

Score: 0.878 · als · 2026-04-26

The hypothesis proposes that loss-of-function mutations in TBK1 contribute to ALS pathogenesis by trapping microglia in

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.865 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular-neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

Score: 0.861 · neuroscience · 2026-04-12

## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance starts from the claim

H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State

Score: 0.856 · neurodegeneration · 2026-04-22

## Mechanistic Overview H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State starts from the claim that

Prime Editing Precision Correction of APOE4 to APOE3 in Microglia

Score: 0.850 · neurodegeneration · 2026-04-04

## Mechanistic Overview Prime Editing Precision Correction of APOE4 to APOE3 in Microglia starts from the claim that mod

TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's D

Score: 0.847 · neurodegeneration · 2026-04-26

TREM2 loss-of-function variants impair microglial survival, clustering around amyloid plaques, and phagocytic clearance,

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot

Score: 0.843 · neurodegeneration · 2026-04-16

## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia

J-protein substrate specificity codes enable HSP70 discrimination of β-sheet ver

Score: 0.840 · protein-biochemistry · 2026-04-28

The HSP70 chaperone system achieves selective recognition of pathogenic protein conformers through a sophisticated clien