gene 2,575 words KG: SCRIB 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neurodevelopment
Contents

SCRIB Gene

🧬 Gene Info
Gene SymbolSCRIB
Full NameScribble Planar Cell Polarity Protein
AliasesScribbled, SCRIB1
Chromosome8q24.3
Functionencodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight220 kDa
Amino Acids1757 aa
Exons34
PathwaysAutophagy, Inflammasome, Phagocytosis
UniProt IDQ14160
NCBI Gene ID23513
Ensembl IDENSG00000103067
OMIM607584
GeneCardsSCRIB
Human Protein AtlasSCRIB
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsNLRP3, MICROGLIA, PARKINSON, AUTOPHAGY, ROS, NEURON
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

See Also (15)

Irisin Therapy — Exercise-Induced Myokine for Neurodege
therapeutic · KG edge: co_discussed
huntington-disease-treatment
therapeutic · KG edge: co_discussed
Hepsin Protein
protein · KG edge: co_discussed
Alzheimer Indonesia
institution · KG edge: co_discussed
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: co_discussed

Knowledge Graph (12 edges)

SCRIB co_discussed STING
SCRIB activates NLRP3
SCRIB co_discussed SPARC
SCRIB co_discussed WAS
SCRIB activates MICROGLIA
SCRIB activates PARKINSON
SCRIB activates AUTOPHAGY
SCRIB activates ROS
SCRIB activates Parkinson
SCRIB activates Neuroinflammation