gene 2,396 words KG: UQCRFS1 2026-03-30
kind:geneevidence:strongsection:genesstate:published
Contents

UQCRFS1 Gene

🧬 Gene Info
Gene SymbolUQCRFS1
Full NameUbiquinol-Cytochrome c Reductase Core Protein 1
AliasesRieske iron-sulfur protein
Chromosome19q12
Functionis a nuclear-encoded mitochondrial protein that serves as a critical core component of complex III (cytochrome bc1 complex) in the electron transport chain[@craft2011].
Primary ExpressionHigh in brain, heart, muscle
Molecular Weight30 kDa
Amino Acids274 aa
Pathwaysmitochondrial function
UniProt IDP31930
NCBI Gene ID27089
Ensembl IDENSG00000127540
OMIM191317
GeneCardsUQCRFS1
Human Protein AtlasUQCRFS1
Associated DiseasesALS, Cardiomyopathy, disease
InteractionsGENES
KG Connections20 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Genes
index · KG edge: causes
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: protects_against
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

UQCRFS1 interacts_with Ms
UQCRFS1 associated_with Als
UQCRFS1 protects_against Mitochondrial Function
UQCRFS1 protects_against Complement
UQCRFS1 causes GENES
UQCRFS1 associated_with ALS
UQCRFS1 expressed_in Fibroblast
UQCRFS1 associated_with Fibroblast
UQCRFS1 associated_with FIBROBLASTS
UQCRFS1 expressed_in Mitochondrial Function