gene 3,403 words KG: CR1 2026-03-25
kind:genesection:genesstate:published
Contents

CR1 Gene — Complement Component 1q Receptor

🧬 Gene Info
Gene SymbolCR1
Full NameComplement Component 1q Receptor
Chromosome1q32.2
Protein TypeReceptor
Functionis a gene located on chromosome 1q32.
Primary ExpressionBlood cells (erythrocytes, leukocytes), Brain (microglia, astrocytes), Kidney, Spleen
Molecular Weight~220 kDa (long), ~60 kDa (short)
Amino Acids1998 aa
Exons38
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Complement, Dysbiosis
UniProt IDP08578
NCBI Gene ID1378
Ensembl IDENSG00000203797
OMIM120600
GeneCardsCR1
Human Protein AtlasCR1
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, CELL SURVIVAL
Known Drugs/CompoundsStem Cell Therapy
InteractionsC4B, C1Q, MS4A6A, ABCA7, PICALM, MS4A4E
KG Connections588 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
SASP-Mediated Complement Cascade Amplification
Score: 0.70

Related Analyses (14)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CR1 associated_with CTSB
CR1 associated_with CTSH
CR1 associated_with EED
CR1 associated_with GRN
CR1 associated_with INPP5D
CR1 associated_with LILRB2
CR1 associated_with PLCG2
CR1 associated_with PSEN1
CR1 associated_with PTK2B
CR1 associated_with SORL1