| Gene Symbol | CRYAB |
| Full Name | Crystallin Alpha B |
| Chromosome | 11q23.1 |
| Function | The CRYAB gene encodes αB-crystallin (also known as CRYAB or HspB5), a small heat shock protein (sHsp) that functions as a molecular chaperone |
| Primary Expression | many tissues including the brain, heart, and skeletal muscle, where it plays critical roles in protein quality control and cellular protection[@jin202 |
| Subcellular Localization | **Oxidation**: Oxidative stress can modify cysteine residues, altering function |
| Pathways | MAPK signaling, Mapk, P38 Mapk, Proteostasis, lipid metabolism |
| UniProt ID | P02511 |
| NCBI Gene ID | 1410 |
| Ensembl ID | ENSG00000109846 |
| OMIM | 123590 |
| GeneCards | CRYAB |
| Human Protein Atlas | CRYAB |
| N-terminal domain | Contains the WDPF motif and hydrophobic regions for client binding |
| C-terminal domain | Contains the α-crystallin domain characteristic of sHsp family |
| Associated Diseases | Als, Alzheimer, Cancer, Diabetes, Ms, Tumor |
| Interactions | HSPA8, SYNGR3, P38, PRDX6, CLU, TNF |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsHPASTRING |